Results 61 to 70 of about 1,668 (171)

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

A continuous spectrophotometric assay method for peptidylarginine deiminase type 4 activity

, 2014
A simple, continuous spectrophotometric assay for peptidylarginine deiminase (PAD) is described. Deimination of peptidylarginine results in the formation of peptidylcitrulline and ammonia.
Liao, Y.F., Hsieh, H.C., Hung, H.C., 洪慧芝, Liu, G.Y.   +4 more
core   +1 more source

Extracellular Vesicle Signatures and Post-Translational Protein Deimination in Purple Sea Urchin (Strongylocentrotus purpuratus) Coelomic Fluid—Novel Insights into Echinodermata Biology

Biology, 2021
The purple sea urchin (Strongylocentrotus purpuratus) is a marine invertebrate of the class Echinoidea that serves as an important research model for developmental biology, cell biology, and immunology, as well as for understanding regenerative responses
Stefania D’Alessio, Katherine M. Buckley, Igor Kraev, Polly Hayes, Sigrun Lange   +4 more
doaj   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Peptidylarginine Deiminase (PAD) Inhibitor Optimization through Displacement of a Trapped Water Molecule

ACS Medicinal Chemistry Letters
Excess protein citrullination, a post-translational modification converting arginine to citrulline, has been associated with a range of autoimmune and neurological disorders, as well as cancers. Protein citrullination is mediated by the peptidylarginine deiminase enzyme family (PAD1-4), and inhibition of one or several PAD isozymes in combination may ...
Mark E. Schnute, Gary M. Chinigo, Kentaro Futatsugi, Masaya Yamaguchi, Scott W. Bagley, Mary Ellen Banker, Jeanne S. Chang, Ming Z. Chen, Won Young Choi, Matthew S. Corbett, Susan E. Drozda, David C. Ebner, Carmen Garcia-Irizarry, Robert Hicklin, Susan Hoy, Wenhua Jiao, Steven Kortum, Katherine L. Lee, David C. Limburg, Frank Lovering, Antonio Moreno, James J. Mousseau, Senliang Pan, Mihir D. Parikh, Jeffrey W. Pelker, Simeon Ramsey, Usa Reilly, Gwenaella Rescourio, Daniel C. Schmitt, Brittany Simpson, Grzegorz J. Skrzypek, Daniel J. Smaltz, Alexandria P. Taylor, Rubben Torella, John I. Trujillo, Felix F. Vajdos, James A. Wepy, Stephen W. Wright, David C. Blakemore, Fabien Vincent, Valerie M. Clerin   +40 more
openaire   +3 more sources

Molecular Quantification of Fibrogenesis and Macrophage Activation Associate With Clinical Worsening in Patients With Cirrhosis

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT Knowledge of the potential of biomarkers for monitoring clinical improvement, assessing trajectory or disease progression in advanced chronic liver disease is still insufficient. This study investigated biomarkers of fibrosis and macrophage activation over time in newly diagnosed patients with cirrhosis and their potential association with ...
Emilie Toft Skovgaard, Jens Peter Goetze, Thit Mynster Kronborg, Søren Møller, Henning Grønbæk, Holger Jon Møller, Morten Karsdal, Diana Julie Leeming, Nina Kimer   +8 more
wiley   +1 more source

Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 5, May 2026.
This graphical abstract summarizes how classical and emerging histone posttranslational modifications (PTMs), together with their chromatin regulators (writers, erasers, and readers), govern major pathobiological programs in cardiovascular disease.
Yu Zheng, Yu‐Xuan Gao, Mei‐Xing Guo, Li‐Ting Wang, Xiao‐Wen Zheng, Yi‐Hao Liao, Ya Li, Jun‐Ping Zhu, Jia‐Ming Wei   +8 more
wiley   +1 more source

Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures [PDF]

, 2021
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with limited survival rate. Roles for peptidylarginine deiminases (PADs) have been studied in relation to a range of cancers with roles in epigenetic regulation (including
Stefania D’Alessio, Uysal Onganer, P., Mortoglou, M., Pinar Uysal-Onganer, Sigrun Lange, D’Alessio, Stefania, Lange, S., Kraev, Igor, Mortoglou, Maria, Igor Kraev, Lange, Sigrun, Uysal-Onganer, Pinar, Maria Mortoglou, D'alessio, S., Kraev, I.   +14 more
core   +1 more source

Profiling Protein Citrullination in Extracellular Vesicles by Single‐Molecule Detection Using Direct Stochastic Optical Reconstruction Microscopy

Journal of Biophotonics, Volume 19, Issue 3, March 2026.
This study identifies post‐translationally citrullinated/deiminated protein cargoes co‐localised to EV subtypes, using super resolution microscopy and dSTORM imaging. The findings expand current understanding of post‐translational modifications in EV‐mediated cellular communication.
Sarah R. Needham, Benjamin M. Davis, Pinar Uysal‐Onganer, Daniel J. Rolfe, Mariya Hristova, Igor Kraev, Jameel M. Inal, Sigrun Lange   +7 more
wiley   +1 more source

Neutrophil Plasticity and NETosis in Tumour Microenvironment: Tumour Evolution and Therapy Resistance

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Neutrophil extracellular traps (NETs) are web‐like formations consisting of DNA‐histone complexes and associated proteins released from activated neutrophils. While NET formation plays an important role in innate immunity, it is also associated with the pathogenesis of autoimmune disorders such as rheumatoid arthritis, psoriasis and systemic lupus ...
Mojdeh Soltani, Sara Falahi, Mohammad Abbaszadeh, Mark J. M. Sullman, Hamed Fouladseresht, Nahid Eskandari, Poorani Gurumallesh   +6 more
wiley   +1 more source