Results 51 to 60 of about 1,668 (171)

Extracellular Vesicles and Post-Translational Protein Deimination Signatures in Mollusca—The Blue Mussel (Mytilus edulis), Soft Shell Clam (Mya arenaria), Eastern Oyster (Crassostrea virginica) and Atlantic Jacknife Clam (Ensis leei)

Biology, 2020
Oysters and clams are important for food security and of commercial value worldwide. They are affected by anthropogenic changes and opportunistic pathogens and can be indicators of changes in ocean environments.
Timothy J. Bowden, Igor Kraev, Sigrun Lange   +2 more
doaj   +1 more source

Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells

, 2023
In brief: DGCR8 microprocessor complex, which is important for miRNA biogenesis, is regulated by peptidylarginine deiminase 2 and expression fluctuates in gonadotrope cells across the mouse estrous cycle.
DeVore, Stanley B, Cherrington, Brian D, Ralston, Brett A, Thompson, Paul R, Flock, Joseph W, Sequoia, Ari O, Navratil, Amy M, Khan, Lamia, Bronnenberg, Trent A   +8 more
core   +1 more source

Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines [PDF]

, 2020
Glioblastoma multiforme (GBM) is an aggressive adult brain tumour with poor prognosis. Roles for peptidylarginine deiminases (PADs) in GBM have recently been highlighted.
Thompson, Paul R., Uysal Onganer, P., Paul R. Thompson, Mahmoud, Rayan, Jameel M. Inal, Rayan Mahmoud, Pinar Uysal-Onganer, Inal, Jameel M., Sigrun Lange, Amy MacLatchy, MacLatchy, Amy, Lange, S., Inal, Jameel, Kraev, Igor, Thompson, Paul R, Igor Kraev, Lange, Sigrun, Paul R. Thompson, Uysal-Onganer, Pinar, Jameel M. Inal, Kraev, I.   +20 more
core   +1 more source

Delayed puberty, gonadotropin abnormalities and subfertility in male Padi2/Padi4 double knockout mice

Reproductive Biology and Endocrinology, 2022
Background Peptidylarginine deiminase enzymes (PADs) convert arginine residues to citrulline in a process called citrullination or deimination. Recently, two PADs, PAD2 and PAD4, have been linked to hormone signaling in vitro and the goal of this study ...
Kelly L. Sams, Chinatsu Mukai, Brooke A. Marks, Chitvan Mittal, Elena Alina Demeter, Sophie Nelissen, Jennifer K. Grenier, Ann E. Tate, Faraz Ahmed, Scott A. Coonrod   +9 more
doaj   +1 more source

Belimumab Decreases Autophagy and Citrullination in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus

Cells, 2022
Belimumab (BLM) is a B lymphocyte stimulator (BLyS) inhibitor approved for the treatment of systemic lupus erythematosus (SLE). Autophagy is a cell survival mechanism involved in the pathogenesis of SLE.
Tania Colasanti, Francesca Romana Spinelli, Cristiana Barbati, Fulvia Ceccarelli, Susanna Scarpa, Marta Vomero, Cristiano Alessandri, Guido Valesini, Fabrizio Conti   +8 more
doaj   +1 more source

Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design

, 2021
Peptidylarginine deiminase type III (PAD3) is an isozyme belonging to the PAD enzyme family that converts arginine to citrulline residue(s) within proteins. PAD3 is expressed in most differentiated keratinocytes of the epidermis and hair follicles, while
Kizawa, Kenji, Sawata, Mizuki, Nagai, Anna, Ite, Kenji, Kitanishi, Kenichi, Akimoto, Megumi, Unno, Masaki, Thompson, Paul R, Takahara, Hidenari, Funabashi, Kazumasa, Mashimo, Ryutaro   +10 more
core   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Peptidylarginine deiminase activity in postmortem white matter of patients with multiple sclerosis

, 1999
The myelin sheath in multiple sclerosis (MS) appears to contain a higher proportion of the citrullinated isoform of myelin basic protein MBP-C8. In vitro, MBP-associated arginine is deiminated to citrulline by the enzyme peptidylarginine deiminase (PAD).
Margreet Schaaf, Schaaf, M, De Keyser, J, Teelken, A, Albert Teelken, Jacques De Keyser   +5 more
core   +2 more sources

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

PADI4 Polymorphisms Confer Risk of Anti-CCP-Positive Rheumatoid Arthritis in Synergy With HLA-DRB1*04 and Smoking

Frontiers in Immunology, 2021
Peptidylarginine deiminases (PADs) catalyze citrullination, a post-translational modification playing a pathogenic role in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA).
Laura Massarenti, Christian Enevold, Dres Damgaard, Niels Ødum, Peter Garred, Morten Frisch, Miriam A. Shelef, Miriam A. Shelef, Søren Jacobsen, Claus Henrik Nielsen, Claus Henrik Nielsen   +10 more
doaj   +1 more source