Results 41 to 50 of about 1,668 (171)

Insights of rheumatoid arthritis risk factors and associations

Journal of Translational Autoimmunity, 2019
Rheumatoid arthritis (RA) is a defective post-translational modification of citrullinated peptides which cause synovial inflammation in joints. The present review elaborates the basic mechanisms of RA and the root causes of molecular mechanisms.
Jangampalli Adi Pradeepkiran
doaj   +1 more source

Peptidylarginine Deiminase and Citrullination: Potential Therapeutic Targets for Inflammatory Diseases [PDF]

, 2013
The multiple post-translational modifications of proteins display specific gain- or loss-of-function under normal and abnormal conditions. These modifications are precisely regulated by post-translational modification enzymes.
장병기, 신성재
core   +1 more source

Are Viral Infections Key Inducers of Autoimmune Diseases? Focus on Epstein–Barr Virus

Viruses, 2022
It is generally accepted that certain viral infections can trigger the development of autoimmune diseases. However, the exact mechanisms by which these viruses induce autoimmunity are still not understood.
Masami Takei, Noboru Kitamura, Yosuke Nagasawa, Hiroshi Tsuzuki, Mitsuhiro Iwata, Yasuko Nagatsuka, Hideki Nakamura, Kenichi Imai, Shigeyoshi Fujiwara   +8 more
doaj   +1 more source

Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer

Frontiers in Pharmacology, 2018
Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication through transfer of proteins and genetic material.
Uchini S. Kosgodage, Rhys Mould, Aine B. Henley, Alistair V. Nunn, Geoffrey W. Guy, E. L. Thomas, Jameel M. Inal, Jimmy D. Bell, Sigrun Lange, Sigrun Lange   +9 more
doaj   +1 more source

Extracellular vesicles, deiminated protein cargo and microRNAs are novel serum biomarkers for environmental rearing temperature in Atlantic cod (Gadus morhua L.)

Aquaculture Reports, 2020
Extracellular vesicles (EVs) are released from cells and carry protein and genetic cargo involved in cell communication. EVs isolated from bodyfluids, including plasma and serum, can also be used as markers of pathophysiological changes. Peptidylarginine
Bergljót Magnadóttir, Pinar Uysal-Onganer, Igor Kraev, Alister W. Dodds, Sigríður Guðmundsdóttir, Sigrun Lange   +5 more
doaj   +1 more source

The lack of association between PADI4_94 or PADI4_104 polymorphisms and RF, ACPA and anti-PAD4 in patients with rheumatoid arthritis

Scientific Reports, 2022
Rheumatoid arthritis (RA) is a chronic autoimmune disease that leads to chronic inflammation of synovial tissue, ultimately causing joint damage, disability, and premature mortality.
Marek Ciesla, Bogdan Kolarz, Dorota Darmochwal-Kolarz   +2 more
doaj   +1 more source

Citrullination and PAD Enzyme Biology in Type 1 Diabetes – Regulators of Inflammation, Autoimmunity, and Pathology

Frontiers in Immunology, 2021
The generation of post-translational modifications (PTMs) in human proteins is a physiological process leading to structural and immunologic variety in proteins, with potentially altered biological functions.
Mei-Ling Yang, Fernanda M. C. Sodré, Mark J. Mamula, Lut Overbergh   +3 more
doaj   +1 more source

The release of zearalenone-induced heterophil extracellular traps in chickens is associated with autophagy, glycolysis, PAD enzyme, and P2X1 receptor

Poultry Science, 2023
: Zearalenone (ZEA) is produced mainly by fungi belonging to genus Fusarium in foods and feeds. Heterophil extracellular traps (HETs) are a novel defense mechanism of chicken innate immunity involving activated heterophils.
Hanpeng Wu, Xuhai Li, Zhan Zhang, Yingrong Ye, Yichun Chen, Jingjing Wang, Zhengtao Yang, Ershun Zhou   +7 more
doaj   +1 more source

A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy

Journal of Extracellular Vesicles, 2015
IntroductionProtein deimination, defined as the post‐translational conversion of protein‐bound arginine to citrulline, is carried out by a family of 5 calcium‐dependent enzymes, the peptidylarginine deiminases (PADs) and has been linked to various cancers. Cellular microvesicle (MV) release, which is involved in cancer progression, and deimination have
Kholia, Sharad, Jorfi, Samireh, Thompson, Paul R., Causey, Corey P., Nicholas, Anthony P., Inal, Jameel M., Lange, Sigrun   +6 more
openaire   +5 more sources

Post-Translational Protein Deimination Signatures in Plasma and Plasma EVs of Reindeer (Rangifer tarandus)

Biology, 2021
The reindeer (caribou) Rangifer tarandus is a Cervidae in the order Artiodactyla. Reindeer are sedentary and migratory populations with circumpolar distribution in the Arctic, Northern Europe, Siberia and North America. Reindeer are an important wild and
Stefania D’Alessio, Stefanía Thorgeirsdóttir, Igor Kraev, Karl Skírnisson, Sigrun Lange   +4 more
doaj   +1 more source