Results 21 to 30 of about 1,668 (171)

Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis

Arthritis Research & Therapy, 2021
Background Mucosal sites are hypothesized to play a role in the development of rheumatoid arthritis (RA). Since serum anti-peptidylarginine deiminase (PAD)4 antibodies, including a subset that cross-react with PAD3 (PAD3/4), are specific for RA and ...
M. Kristen Demoruelle, Hong Wang, Ryan L. Davis, Ashley Visser, Johnny Hoang, Jill M. Norris, V. Michael Holers, Kevin D. Deane, Erika Darrah   +8 more
doaj   +2 more sources

Novel Biomarker for Rheumatoid Arthritis: Serum Peptidylarginine Deiminase 4-Potentiating Activity in an Anti-Citrullinated Protein Antibody-Positive At-Risk Population. [PDF]

Scand J Immunol
In an ACPA‐positive at‐risk RA cohort, serum PAD4‐potentiating activity was measured by HPLC. PAD4act‐positivity identified a subgroup that progressed to clinical arthritis significantly faster, independent of baseline inflammatory markers. Moreover, individuals with high PAD4act more often carried HLA‐DRB shared epitope alleles, a common genetic risk ...
Kaminska M, Joshua V, Bielecka E, Kantyka T, Chrobak M, Lundberg K, Hensvold A, Potempa J, Mydel P.   +8 more
europepmc   +2 more sources

The Association Between Serum Immunoglobulin G Titers Against Porphyromonas gingivalis and Chronic Kidney Disease in Patients With Rheumatoid Arthritis and Periodontitis: A Retrospective Cohort Study. [PDF]

Clin Exp Dent Res
ABSTRACT Objectives Chronic kidney disease (CKD) is relatively common in patients with rheumatoid arthritis (RA). Periodontitis and periodontopathic Porphyromonas gingivalis are risk factors for CKD. However, the association of serum immunity to P. gingivalis and its peptidylarginine deiminase (PPAD), as well as periodontitis severity, with CKD in ...
Kobayashi T, Ito S, Sugita N, Murasawa A, Ishikawa H, Tabeta K.   +5 more
europepmc   +2 more sources

Peptidylarginine deiminase 4 overexpression resensitizes MCF-7/ADR breast cancer cells to adriamycin via GSK3β/p53 activation

Cancer Management and Research, 2019
Qianqian Zhou,1,* Chao Song,1,* Xiaoqiu Liu,2,3,* Hao Qin,1 Lixia Miao,1 Xuesen Zhang1 1State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China; 2Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical ...
Zhou Q, Song C, Liu X, Qin H, Miao L, Zhang X   +5 more
doaj   +1 more source

Aggregatibacter actinomycetemcomitans as the Aetiological Cause of Rheumatoid Arthritis: What Are the Unsolved Puzzles?

Toxins, 2022
Leukotoxin A (LtxA) is the major virulence factor of an oral bacterium known as Aggregatibacter actinomycetemcomitans (Aa). LtxA is associated with elevated levels of anti-citrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) patients ...
Sung Cheng Looh, Zoey May Pheng Soo, Jia Jia Wong, Hok Chai Yam, Sook Khuan Chow, Jung Shan Hwang   +5 more
doaj   +1 more source

The virtues and vices of protein citrullination

Royal Society Open Science, 2022
The post-translational modification of proteins expands the regulatory scope of the proteome far beyond what is achievable through genome regulation. The field of protein citrullination has seen significant progress in the last two decades.
Maria A. Christophorou
doaj   +1 more source

IL-17A Promotes NETs Formation via the PKCζ-ERK-ROS-PAD4 Pathway in a Mouse Model of Ischemic Stroke. [PDF]

CNS Neurosci Ther
Our study demonstrates that IL‐17A promotes NET formation by upregulating PAD4 through the PKCζ–ERK–ROS pathway, thereby exacerbating ischemic brain injury. IL‐17A regulates NET formation through this newly identified molecular pathway, and targeting this pathway may offer a novel therapeutic strategy for stroke.
Liu C, Chen Q, Chen W, Han X, Qiao X, Guo J, Su W, Dai Q.   +7 more
europepmc   +2 more sources

FRI0025 Serum mediated peptidylarginine deiminase (PAD) activation in early rheumatoid arthritis [PDF]

Annals of the Rheumatic Diseases, 2018
Background Peptidylarginine deiminases (PADs) are a family of enzymes catalysing the conversion of arginine residues to citrulline, a post translational modification which has been recognised in the generation of neo-epitopes due to anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA).
M.K. Jonsson, K. Falkowski, A. Aliko, A.-B. Aga, S. Lillegraven, J. Sexton, B.-T.S. Fevang, P. Mydel, E.A. Haavardsholm   +8 more
openaire   +1 more source

Citrullinated Histone H3 as a Therapeutic Target for Endotoxic Shock in Mice

Frontiers in Immunology, 2020
Sepsis results in millions of deaths every year, with acute lung injury (ALI) being one of the leading causes of mortality in septic patients. As neutrophil extracellular traps (NETs) are abundant in sepsis, neutralizing components of NETs may be a ...
Qiufang Deng, Qiufang Deng, Baihong Pan, Baihong Pan, Hasan B. Alam, Yingjian Liang, Yingjian Liang, Zhenyu Wu, Zhenyu Wu, Baoling Liu, Nirit Mor-Vaknin, Xiuzhen Duan, Aaron M. Williams, Yuzi Tian, Yuzi Tian, Justin Zhang, Yongqing Li   +16 more
doaj   +1 more source

Extracellular vesicle signatures and protein citrullination are modified in shore crabs (Carcinus maenas) infected with Hematodinium sp

Virulence, 2023
Epizootiologists recurrently encounter symbionts and pathobionts in the haemolymph (blood equivalent) of shellfish. One such group is the dinoflagellate genus Hematodinium, which contains several species that cause debilitating disease in decapod ...
Christopher J. Coates, Igor Kraev, Andrew F. Rowley, Sigrun Lange   +3 more
doaj   +1 more source