Results 71 to 80 of about 1,668 (171)

The Research Progress of Tumor‐Associated Macrophages in Prostate Cancer

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Prostate cancer (PCa) is a major global cancer burden in men, and its treatment is hindered by the immunosuppressive tumor microenvironment. In this context, PCa initially shows a favorable response to immunotherapy. However, as the disease progresses, the tumor gradually develops resistance to immunotherapy, with tumor‐associated macrophages (TAMs ...
Si Shen, Zhonghao Tang, Chen Guo, Anjie Chen, Yuanyuan Mi, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders

Journal of Immunology Research, 2019
A protein undergoes many types of posttranslation modification. Citrullination is one of these modifications, where an arginine amino acid is converted to a citrulline amino acid.
Mohammed Alghamdi, Doaa Alasmari, Amjad Assiri, Ehab Mattar, Abdullah A. Aljaddawi, Sana G. Alattas, Elrashdy M. Redwan   +6 more
doaj   +1 more source

Periodontitis Salivary Microbiota Exacerbates Murine Rheumatoid Arthritis via Gut Dysbiosis and Immune Dysregulation

The FASEB Journal, Volume 39, Issue 23, 15 December 2025.
Salivary multiomics from healthy, PD, RA, and PD‐RA cohorts identified PD−/RA‐linked microbial and metabolic signatures. We then transplanted salivary microbiota from a PD donor or a healthy donor into collagen‐induced arthritis mice. PD microbiota colonized the gut, reshaped communities, weakened epithelial tight junctions, and provoked systemic ...
Ruiyang Ge, Rong Liu, Yingying Zhou, Ziyao Zhuang, Haowei Mao, Wenzheng Liao, Lei Han, Wenrong Yang, Fuhua Yan, Di Cui   +9 more
wiley   +1 more source

Potential protein targets of the peptidylarginine deiminase 2 and peptidylarginine deiminase 4 enzymes in rheumatoid synovial tissue and its possible meaning [PDF]

, 2016
Objective: The molecular mechanism of citrullination involves the calcium-dependent peptidylarginine deiminase (PAD) family of enzymes. These enzymes induce a stereochemical modification of normal proteins and transform them into autoantigens, which in
Badillo Soto, Martha Adriana, Rodríguez Rodríguez, Mayra, Martha Adriana Badillo Soto, Pérez Pérez, María Elena, Carrillo Jimenez, Miguel Angel, Leonel Daza Benitez, Mayra Rodríguez Rodríguez, Bollain y Goytia, Juan José, Daza Benitez, Leonel, Avalos Díaz, Esperanza del Refugio, Esperanza Avalos Díaz, Juan José Bollain y Goytia, Miguel Angel Carrillo Jiménez, Rafael Herrera Esparza, María Elena Pérez Pérez, Herrera Esparza, Rafael   +15 more
core   +1 more source

Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract Oral dysbiosis contributes to Alzheimer's disease (AD) by promoting neuroinflammation. Pathobionts such as Porphyromonas gingivalis, Treponema denticola, and Fusobacterium nucleatum release virulence factors that induce amyloid beta aggregation and tau hyperphosphorylation, while the loss of commensals like Streptococcus salivarius and ...
Gilliana Rozenblum, Karima Ait‐Aissa, Gadeer Zahran, Mahdieh Alipour, Amal M. Sahyoun, Undral Munkhsaikhan, Adam Kassan, Tauheed Ishrat, Qi Wang, Ammaar H. Abidi, Modar Kassan   +10 more
wiley   +1 more source

Air Pollution‐Induced Epigenetic Regulation in Respiratory Diseases: Mechanisms, Dysregulation, and Therapeutic Opportunities

MedComm – Future Medicine, Volume 4, Issue 4, December 2025.
Air pollution, a major global health hazard, contributes to asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer via four core epigenetic pathways (DNA/RNA methylation, noncoding RNAs, and histone modifications), shaping gene expression and driving disease pathogenesis.
Ruitong Zeng, Jiliu Liu, Guoping Li, Junyi Wang, Anying Xiong, Ying Xiong, Xiang He   +6 more
wiley   +1 more source

Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase [PDF]

, 2015
Citrullination is a post-translational modification of higher organisms that deiminates arginines in proteins and peptides. It occurs in physiological processes but also pathologies such as multiple sclerosis, fibrosis, Alzheimer’s disease and rheumatoid
Mizgalska, Danuta, Sroka, Aneta, Veillard, Florian, Uson, Isabel, Potempa, Jan, Garcia-Ferrer, Irene, Kantyka, Tomasz, Millan, Claudia, Goulas, Theodoros, Potempa, Barbara, Sola, Maria, Szmigielski, Borys, Gomis-Ruth, F. Xavier, Mydel, Piotr, Guevara, Tibisay, Mydel, Piotr Mateusz   +15 more
core   +1 more source

PEPTIDYLARGININE DEIMINASE (PAD) INHIBITORS

, 2010
14 januari ...
Blaauw, R.H., Pruijn, G.J.M., Raats, J.M.H., Rutjes, F.P.J.T., Drijfhout, J.W.   +4 more
openaire   +1 more source

Citrullination of AKT2 Catalyzed by PAD1 Facilitates the Maintenance of Stemness Characteristics of Ovarian Cancer Stem‐Like Cells in Ovarian Cancer

Advanced Science, Volume 12, Issue 39, October 20, 2025.
PAD1 is upregulated within the CD133+ subset or cisplatin‐resistant ovarian cancer cells, which is positively associated with the upregulation of stemness‐related markers and maintenance of stemness in OCSLCs. Mechanistically, PAD1‐catalyzed AKT2 citrullination at R202 facilitates AKT2 phosphorylation, promoting CEBPβ expression and its binding to the ...
Teng Xue, Xiaoqiu Liu, Chao Song, Shujia Fei, Jian Gu, Yun Han, Jia Xing, Xiaohan Liu, Fei Liang, Paul R Thompson, Xuesen Zhang   +10 more
wiley   +1 more source

Study on the role of protein deiminases in the nervous system

, 2011
"Study on the role of protein deiminases in the nervous system" Citrullination (deimination) is the conversion of protein-bound arginine to citrulline. Citrullination is catalyzed by a family of calcium-dependent enzymes, the peptidylarginine deiminases (
MILLARTE, VALENTINA
core