Results 111 to 120 of about 11,623 (233)

Characterization of a cDNA Encoding a Cytosolic Peptidylprolyl Cis‐Trans ‐Isomerase from Blattella Germanica [PDF]

European Journal of Biochemistry, 1995
Cyclophilins are an abundant and ubiquitous class of proteins first identified by their high affinity for the immunosuppressive drug cyclosporin A. Cyclophilins have peptidylprolyl cis/trans ‐isomerase activity in vitro, and thus may be involved in protein folding and trafficking in vivo.In this study, we report the cloning and characterization of a ...
J, Martinez-Gonzalez, F G, Hegardt
openaire   +2 more sources

Metabolic enzyme PFKFB3 mediates matrix stiffness‐potentiated tumour growth and radiotherapeutic resistance in HCC

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
This study proposes a stiffness‐triggered pathway that co‐opts PFKFB3 expression and localization to fuel HCC growth and compromise radiotherapy efficacy. Specifically, matrix stiffness suppresses PFKFB3 ubiquitination by downregulating E3 ubiquitin ligase NEDD4 expression, and then enhances the stablity of PFKFB3 protein to increase glycolysis ...
Mimi Wang, Jiajun Li, Jiali Qian, Xi Zhang, Miao Li, Yingying Zhao, Zhiming Wang, Kun Guo, Dongmei Gao, Yan Zhao, Rongxin Chen, Zhenggang Ren, Taiwei Sun, Fan Wang, Jiefeng Cui   +14 more
wiley   +1 more source

Shortfalls in the peptidyl-prolyl cis–trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias

Neurobiology of Disease, 2004
The peptidyl-prolyl cis–trans isomerase (PPIase) Pin1 modulates the activity of a range of target proteins involved in the cell cycle, transcription, translation, endocytosis, and apoptosis by facilitating dephosphorylation of phosphorylated serine or ...
Julian R. Thorpe, Sabrina Mosaheb, Lida Hashemzadeh-Bonehi, Nigel J. Cairns, John E. Kay, Simon J. Morley, Stuart L. Rulten   +6 more
doaj   +1 more source

The human FK506-binding proteins: characterization of human FKBP19 [PDF]

, 2006
Analysis of the human repertoire of the FK506-binding protein (FKBP) family of peptidyl-prolyl cis/trans isomerases has identified an expansion of genes that code for human FKBPs in the secretory pathway.
A Galat, A Galat, A Pahl, AN Fedorov, CE Patterson, CE Patterson, Colin Robinson, DA Peattie, DS Horowitz, E Lam, E Pennisi, EC Davis, EK Baker, G Fischer, G Heijne von, H Arakawa, H Inoue, Hilda Tateossian, JD Thompson, JE Kay, JE Kay, JJ Siekierka, JJ Siekierka, John E. Kay, K Ishikawa, K Nakai, KT Bush, Lucy Gettins, M Shadidy, N Kuzhandaivelu, R Ranganathan, RD Teasdale, RF Standaert, Ross A. Kinloch, S Munro, SC Nair, Stuart L. Rulten, SW Michnick, T Nakamura, T Ratajczak, TJ Pemberton, X Meng, YJ Jin, YJ Jin   +43 more
core   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Reference loci for RT-qPCR analysis of differentiating human embryonic stem cells [PDF]

, 2013
Background: Selecting stably expressed reference genes is essential for proper reverse transcription quantitative polymerase chain reaction gene expression analysis. However, this choice is not always straightforward. In the case of differentiating human
De Sutter, Petra, Deforce, Dieter, Heindryckx, Björn, O'Leary, Thomas, Van Neste, Christophe, Vandesompele, Jo, Vossaert, Liesbeth   +6 more
core   +2 more sources

Immunophenotyping and Mutation Analysis of Canine Intestinal T‐Cell Lymphoma: A Comparative Pathological Study of Human Enteropathy‐Associated T‐Cell Lymphoma

Veterinary and Comparative Oncology, Volume 23, Issue 4, Page 567-579, December 2025.
ABSTRACT Human enteropathy‐associated T‐cell lymphoma (EATL) is a rare primary aggressive intestinal T‐cell lymphoma associated with celiac disease and is considered to be a neoplasm of intraepithelial lymphocytes (IELs) with an innate lymphoid cell (ILC)‐like immunophenotype. The lack of an animal model has delayed the elucidation of its pathogenesis.
Kazuhiro Kojima, James K. Chambers, Ko Nakashima, Kazumi Nibe, Kazuyuki Uchida   +4 more
wiley   +1 more source

Distinct fungal microbiomes of two Thai commercial stingless bee species, Lepidotrigona terminata and Tetragonula pagdeni suggest a possible niche separation in a shared habitat

Frontiers in Cellular and Infection Microbiology
Stingless bees, a social corbiculate bee member, play a crucial role in providing pollination services. Despite their importance, the structure of their microbiome, particularly the fungal communities, remains poorly understood.
Diana C. Castillo, Diana C. Castillo, Diana C. Castillo, Chainarong Sinpoo, Chainarong Sinpoo, Chainarong Sinpoo, Patcharin Phokasem, Patcharin Phokasem, Patcharin Phokasem, Rujipas Yongsawas, Rujipas Yongsawas, Chakriya Sansupa, Korrawat Attasopa, Korrawat Attasopa, Korrawat Attasopa, Nakarin Suwannarach, Nakarin Suwannarach, Nakarin Suwannarach, Sahutchai Inwongwan, Sahutchai Inwongwan, Sahutchai Inwongwan, Nuttapol Noirungsee, Nuttapol Noirungsee, Nuttapol Noirungsee, Terd Disayathanoowat, Terd Disayathanoowat, Terd Disayathanoowat   +26 more
doaj   +1 more source

Aurora-A overexpression as an early marker of reflux-related columnar mucosa and Barrett's oesophagus. [PDF]

, 2007
BACKGROUND: The development of oesophageal adenocarcinoma is generally closely associated with the presence of a specialised intestinal-type epithelium such as that found in Barrett's oesophagus (BO).
AGNESE, Valentina, ARAGONA, Federico, BAZAN, Viviana, CABIBI, Daniela, CALCARA, Donatella, COLUCCI, G, FIORENTINO, Eugenio, GEBBIA, Nicolo', INTRIVICI, Chiara, PANTUSO, Gianni, RUSSO, Antonio, TERRASI, Marianna   +11 more
core   +1 more source

Elevated cortisol concentration in preterm sheep fetuses impacts heart development

Experimental Physiology, Volume 110, Issue 12, Page 1928-1947, December 1, 2025.
Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi, Stacey L. Holman, Melanie R. Bertossa, Ashley S. Meakin, Vicki L. Clifton, Kent L. Thornburg, I. Caroline McMillen, Michael D. Wiese, Mitchell C. Lock, Janna L. Morrison   +9 more
wiley   +1 more source