Results 91 to 100 of about 7,517 (194)

CypA Mediates Non‐Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang, An Li, Ziwei Song, Xiangming Liu, Yong Ge, Zhiqiao Chen, Yuhui Liu, Boyu Zhang, Hao Zhang, Ting Lan   +9 more
wiley   +1 more source

The chaperone function of cyclophilin 40 maps to a cleft between the prolyl isomerase and tetratricopeptide repeat domains

, 2006
Cyclophilin 40 (CyP40), an immunophilin cochaperone present in steroid receptor-Hsp90 complexes, contains an N-terminal peptidylprolyl isomerase (PPIase) domain separated from a C-terminal Hsp90-binding tetratricopeptide repeat (TPR) domain by a 30 ...
Carrello, Amerigo, Mok, Danny, Ratajczak, Thomas, Allan, Rudi K., Wangoo, Kiran, Walkinshaw, Malcolm D.   +5 more
core   +1 more source

Biological Actions of the Hsp90-binding Immunophilins FKBP51 and FKBP52

Biomolecules, 2019
Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-isomerase domain. High molecular weight immunophilins are characterized by the additional presence of tetratricopeptide-repeats (TPR) through which they bind to the 90 ...
Nadia R. Zgajnar, Sonia A. De Leo, Cecilia M. Lotufo, Alejandra G. Erlejman, Graciela Piwien-Pilipuk, Mario D. Galigniana   +5 more
doaj   +1 more source

Biomarkers in patients with clinical signs of mild cognitive impairment or mild Alzheimer's disease but without amyloid deposits on positron emission tomography: Results from Bio‐Hermes Study participants

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) study participants may present with cognitive impairment who do not have brain amyloid deposits (Aβ−). Identifying predictive biomarkers for non‐amyloid‐related CI may provide better screening tests for trials seeking only CI Aβ+ participants and new therapy targets.
Richard C. Mohs, Douglas W. Beauregard, Lynne Hughes, Cyndy B. Cordell, Allan I. Levey, Saima Rathore, Nicholas T. Seyfried, Erik C. B. Johnson, Jessie Nicodemus‐Johnson, Joshua Christensen, Robin Wolz, John Dwyer   +11 more
wiley   +1 more source

Novel Regulation of Alpha-Toxin and the Phenol-Soluble Modulins by Peptidyl-Prolyl cis/trans Isomerase Enzymes in Staphylococcus aureus

Toxins, 2019
Peptidyl-prolyl cis/trans isomerases (PPIases) are enzymes that catalyze the cis-to-trans isomerization around proline bonds, allowing proteins to fold into their correct confirmation. Previously, we identified two PPIase enzymes in Staphylococcus aureus
Rebecca A. Keogh, Rachel L. Zapf, Emily Trzeciak, Gillian G. Null, Richard E. Wiemels, Ronan K. Carroll   +5 more
doaj   +1 more source

Interaction of the periplasmic peptidylprolyl cis-trans isomerase SurA with model peptides: The N-terminal region of SurA is essential and sufficient for peptide binding

, 2001
One of the rate-limiting steps in protein folding has been shown to be the cis-trans isomerization of proline residues, which is catalyzed by a range of peptidylprolyl cis-trans isomerases.
Helen Webb (5178887), Rosalyn J Marchant (16294646), Peter Klappa (16294649), Lloyd W Ruddock (16294643), Kim Jonas (3525977)   +4 more
core  

The structure of a Burkholderia pseudomallei immunophilin–inhibitor complex reveals new approaches to antimicrobial development

, 2011
Mips (macrophage infectivity potentiators) are a subset of immunophilins associated with virulence in a range of micro-organisms. These proteins possess peptidylprolyl isomerase activity and are inhibited by drugs including rapamycin and tacrolimus.
O'Shea, Katherine, Richard W. Titball, Katherine O'Shea, Titball, Richard W, Norville, Isobel H, Gabriele Varani, Isobel H. Norville, Nicholas J. Harmer, Mitali Sarkar-Tyson, Sarkar-Tyson, Mitali, Varani, Gabriele, Suxin Zheng, Harmer, Nicholas J, Zheng, Suxin   +13 more
core   +1 more source

Expression levels of Akt Isoforms in MCF-7 cells by stimulation of with human sera.

, 2022
MCF-7 cells stimulated for 10 minutes with recombinant human insulin (Ins) (0.5 U/ml) (positive control of activation of IR/Akt pathway) and 5% NWSPre or OSPre or OSPost or NWSPost after 10 min. RT-PCR for Akt isoforms: Akt isoform 1 (Akt-1), Akt isoform
Antonio Ramírez-Ruíz (12407266), Sandra L. Romero-Córdoba (12407248), Sigifredo Pedraza-Sánchez (12407269), María A. Naranjo-Meneses (12407254), Eduardo García-García (12407257), Laura C. Flores-García (12407242), José L. Ventura-Gallegos (12407245), Alberto J. Cabrera-Quintero (12407263), Alejandro Zentella-Dehesa (419030), Felipe Vadillo-Ortega (83607), Alfredo J. Hernández-Juárez (12407251), Juan Pablo Méndez (12407260), Noemi Meraz-Cruz (400109)   +12 more
core   +1 more source

Host Cell Peptidylprolyl cis-trans Isomerases as Immune Modulators of HIV-1 Infection [PDF]

, 2020
Since the 1980s, the human immunodeficiency virus 1 (HIV-1) has been acknowledged as the trigger for AIDS, the acquired immunodeficiency syndrome. Every year, worldwide approximately 700,000 people die from late effects of HIV-1 infection and AIDS (UNAIDS, 2018).
openaire   +1 more source

The molecular mechanisms of peptidyl-prolyl cis/trans isomerase Pin1 and its relevance to kidney disease

Frontiers in Pharmacology
Pin1 is a member of the peptidyl-prolyl cis/trans isomerase subfamily and is widely expressed in various cell types and tissues. Alterations in Pin1 expression levels play pivotal roles in both physiological processes and multiple pathological conditions,
Shukun Wu, Yurong Zou, Xiaoqiu Tan, Shuang Yang, Shuang Yang, Tangting Chen, Jiong Zhang, Xingli Xu, Xingli Xu, Fang Wang, Wei Li   +10 more
doaj   +1 more source