Results 81 to 90 of about 7,517 (194)

Validation of gene expression profiles obtained by Affymetrix transcriptional profiling by quantitative real time PCR for six transcripts in livers isolated from SHR-CRP rats treated with fumaric acid esters (FAE) (solid bars) versus untreated SHR-CRP controls (open bars).

, 2014
Expression of selected genes was normalized relative to the expression of the peptidylprolyl isomerase A (Ppia) gene, which served as an internal control.
Jan Šilhavý (596024), Miroslava Šimáková (596028), Ludmila Kazdová (596031), Hynek Strnad (168251), Vojtěch Škop (596030), Václav Zídek (596025), Petr Mlejnek (596026), Olena Oliyarnyk (596029), Theodore Kurtz (596032), Michal Pravenec (250703), Vladimír Landa (596027)   +10 more
core   +1 more source

Shortfalls in the peptidyl-prolyl cis–trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias

Neurobiology of Disease, 2004
The peptidyl-prolyl cis–trans isomerase (PPIase) Pin1 modulates the activity of a range of target proteins involved in the cell cycle, transcription, translation, endocytosis, and apoptosis by facilitating dephosphorylation of phosphorylated serine or ...
Julian R. Thorpe, Sabrina Mosaheb, Lida Hashemzadeh-Bonehi, Nigel J. Cairns, John E. Kay, Simon J. Morley, Stuart L. Rulten   +6 more
doaj   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Distinct fungal microbiomes of two Thai commercial stingless bee species, Lepidotrigona terminata and Tetragonula pagdeni suggest a possible niche separation in a shared habitat

Frontiers in Cellular and Infection Microbiology
Stingless bees, a social corbiculate bee member, play a crucial role in providing pollination services. Despite their importance, the structure of their microbiome, particularly the fungal communities, remains poorly understood.
Diana C. Castillo, Diana C. Castillo, Diana C. Castillo, Chainarong Sinpoo, Chainarong Sinpoo, Chainarong Sinpoo, Patcharin Phokasem, Patcharin Phokasem, Patcharin Phokasem, Rujipas Yongsawas, Rujipas Yongsawas, Chakriya Sansupa, Korrawat Attasopa, Korrawat Attasopa, Korrawat Attasopa, Nakarin Suwannarach, Nakarin Suwannarach, Nakarin Suwannarach, Sahutchai Inwongwan, Sahutchai Inwongwan, Sahutchai Inwongwan, Nuttapol Noirungsee, Nuttapol Noirungsee, Nuttapol Noirungsee, Terd Disayathanoowat, Terd Disayathanoowat, Terd Disayathanoowat   +26 more
doaj   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, Volume 108, Issue 2, Page 676-693, February 2026.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

Native Recombinant Cyclophilins A, B, and C Degrade DNA Independently of Peptidylprolyl cis-trans -Isomerase Activity: POTENTIAL ROLES OF CYCLOPHILINS IN APOPTOSIS

, 1997
Previous work in our laboratory (Montague, J., Gaido, M., Frye, C., and Cidlowski, J. (1994) J. Biol. Chem. 269, 18877-18880) has shown that human recombinant cyclophilins A, B, and C have sequence homology with the apoptotic nuclease NUC18 and that ...
Cidlowski, John A., Hughes Jr., Francis M., Montague, Jennifer W.   +2 more
core   +2 more sources

The prolyl-isomerase Pin1 activates the mitochondrial death program of p53.

, 2012
In response to intense stress, the tumor protein p53 (p53) tumor suppressor rapidly mounts a direct mitochondrial death program that precedes transcription-mediated apoptosis.
DEL SAL, GIANNINO, SORRENTINO, GIOVANNI, Moll U, Sorrentino G, Mantovani F, Mioni M, Giorgi C, RUGGERI, NAOMI, Del Sal G., PINTON, Paolo, Pinton P, MANTOVANI, FIAMMA, GIORGI, Carlotta, Ruggeri N   +13 more
core   +2 more sources

Ligand-based pharmacophore modelling, structure optimisation, and biological evaluation for the identification of 2-heteroarylthio-N-arylacetamides as novel HSP90 C-terminal inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry
Targeting Heat shock protein 90 (HSP90) C-terminus is an important strategy to develop HSP90 inhibitors without inducing heat shock response. The development of C-terminal inhibitors, however, is hampered by a lack of understanding regarding the ...
Yajun Liu, Chenyao Li, Yajing Li, Shuming Zhang, Ning Zhang, Xiaobo Bian, Shutao Tan   +6 more
doaj   +1 more source

Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease

Neural Plasticity, 2017
Synaptic loss is the structural basis for memory impairment in Alzheimer’s disease (AD). While the underlying pathological mechanism remains elusive, it is known that misfolded proteins accumulate as β-amyloid (Aβ) plaques and hyperphosphorylated Tau ...
Lingyan Xu, Zhiyun Ren, Frances E. Chow, Richard Tsai, Tongzheng Liu, Flavio Rizzolio, Silvia Boffo, Yungen Xu, Shaohui Huang, Carol F. Lippa, Yuesong Gong   +10 more
doaj   +1 more source

Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2017
Medulloblastoma is the most common malignant brain tumor in children. Therapeutic approaches to medulloblastoma (combination of surgery, radiotherapy, and chemotherapy) have led to significant improvements, but these are achieved at a high cost to ...
Tao Xu, Honglai Zhang, Sung-Soo Park, Sriram Venneti, Rork Kuick, Kimberly Ha, Lowell Evan Michael, Mariarita Santi, Chiyoko Uchida, Takafumi Uchida, Ashok Srinivasan, James M. Olson, Andrzej A. Dlugosz, Sandra Camelo-Piragua, Jean-François Rual   +14 more
doaj   +1 more source