Results 81 to 90 of about 7,181 (160)

Novel Regulation of Alpha-Toxin and the Phenol-Soluble Modulins by Peptidyl-Prolyl cis/trans Isomerase Enzymes in Staphylococcus aureus

Toxins, 2019
Peptidyl-prolyl cis/trans isomerases (PPIases) are enzymes that catalyze the cis-to-trans isomerization around proline bonds, allowing proteins to fold into their correct confirmation. Previously, we identified two PPIase enzymes in Staphylococcus aureus
Rebecca A. Keogh, Rachel L. Zapf, Emily Trzeciak, Gillian G. Null, Richard E. Wiemels, Ronan K. Carroll   +5 more
doaj   +1 more source

Peptidylprolyl Isomerase a Regulates DNA Damage Repair and Serves as a Prognostic Biomarker in Lung Adenocarcinoma

Dose-Response
Background This study investigated the role of peptidylprolyl isomerase A (PPIA) in lung adenocarcinoma (LUAD) using bioinformatics approaches and experimental validation.
Li Zou, Bixin Ren, Ying Wan, Xin Wang, Ruichi Shen, Wenlang Zhu, Limin Jin, Qiliang Peng, Ye Tian   +8 more
doaj   +1 more source

Host Cell Peptidylprolyl cis-trans Isomerases as Immune Modulators of HIV-1 Infection [PDF]

, 2020
Since the 1980s, the human immunodeficiency virus 1 (HIV-1) has been acknowledged as the trigger for AIDS, the acquired immunodeficiency syndrome. Every year, worldwide approximately 700,000 people die from late effects of HIV-1 infection and AIDS (UNAIDS, 2018).
openaire   +1 more source

The molecular mechanisms of peptidyl-prolyl cis/trans isomerase Pin1 and its relevance to kidney disease

Frontiers in Pharmacology
Pin1 is a member of the peptidyl-prolyl cis/trans isomerase subfamily and is widely expressed in various cell types and tissues. Alterations in Pin1 expression levels play pivotal roles in both physiological processes and multiple pathological conditions,
Shukun Wu, Yurong Zou, Xiaoqiu Tan, Shuang Yang, Shuang Yang, Tangting Chen, Jiong Zhang, Xingli Xu, Xingli Xu, Fang Wang, Wei Li   +10 more
doaj   +1 more source

Establishment of a method for detecting nucleotide polymorphism of SLC39A13 gene based on ARMS-PCR [PDF]

Journal of Hebei University of Science and Technology
In order to achieve its nucleotide polymorphism (SNP) accurate typing, this paper establishes a molecular diagnostic technique based on fluorescent quantitative PCR for accurate genotyping of the nucleotide polymorphism (SNP) at the rs755555 locus of the
Bingqian GUO, Mengyu LI, Rui WANG, Shusong WANG, Huiyong FENG, Tianming LI   +5 more
doaj   +1 more source

Editorial: Phosphorylation-Dependent Peptidyl-Prolyl Cis/Trans Isomerase PIN1

Frontiers in Cell and Developmental Biology, 2020
Jormay Lim, Tae Ho Lee, Futoshi Suizu
doaj   +1 more source

Multidimensional pan-cancer analysis reveals the impact of PPIA on tumor epigenetic modifications and immune regulation

Scientific Reports
Peptidylprolyl isomerase A (PPIA) is a key molecule involved in various biological functions and has been implicated in multiple diseases. However, the biological significance of PPIA in pan-cancer remains unclear.
Yuanqian Yao, Xueqing Gong, Hui Li
doaj   +1 more source

Deletion of a Peptidylprolyl Isomerase Gene Results in the Inability of Caldicellulosiruptor bescii To Grow on Crystalline Cellulose without Affecting Protein Glycosylation or Growth on Soluble Substrates. [PDF]

Appl Environ Microbiol, 2020
Russell JF, Russo ML, Wang X, Hengge N, Chung D, Wells L, Bomble YJ, Westpheling J.   +7 more
europepmc   +1 more source

PPIA dictates NRF2 stability to promote lung cancer progression

Nature Communications
Nuclear factor erythroid 2-related factor 2 (NRF2) hyperactivation has been established as an oncogenic driver in a variety of human cancers, including non-small cell lung cancer (NSCLC). However, despite massive efforts, no specific therapy is currently
Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang   +18 more
doaj   +1 more source

PPIL2 is a target of the JAK2/STAT5 pathway and promotes myeloproliferation via degradation of p53

The Journal of Clinical Investigation
The activated JAK2/STAT pathway is characteristic of myeloproliferative neoplasms (MPNs). The pleckstrin 2 (PLEK2) signalosome is downstream of the JAK2/STAT5 pathway and plays an important role in MPN development.
Pan Wang, Xu Han, Kehan Ren, Ermin Li, Honghao Bi, Inci Aydemir, Madina Sukhanova, Yijie Liu, Jing Yang, Peng Ji   +9 more
doaj   +1 more source