Results 61 to 70 of about 7,181 (160)

Research progress of the impact of Pin1 on the pathogenesis of Alzheimer's disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
Peptidyl-prolyl cis/trans isomerase (Pin1) has been identified as an important factor that can affect many neurodegenerative diseases as well as neoplasms.
Wei LI, Shi-fu XIAO
doaj  

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications

WIREs RNA, Volume 17, Issue 4, July/August 2026.
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus, Shalon Suzanne Pinto, Sai Samanvitha Madagundapalli Ramakrishna, Dechamma Pandyanada Nanjappa, Gunimala Chakraborty, Anirban Chakraborty   +5 more
wiley   +1 more source

Glucocorticoid Receptor Translational Isoforms Generate Unique Glucocorticoid Responses in the Mouse Brain

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
GR‐A knockin mice were generated that express the classic full‐length glucocorticoid receptor (GR‐A) but lack the highly conserved translational isoforms GR‐B, GR‐C1, GR‐C2, GR‐C3, GR‐D1, GR‐D2, and GR‐D3 that have progressively shorter N‐terminal transactivation domains (NTDs).
Robert H. Oakley, Tatsuya Sueyoshi, Sivapriya Ramamoorthy, Viktoriya D. Nikolova, David R. Goulding, Jianying Li, Manas K. Ray, Sheryl S. Moy, John A. Cidlowski   +8 more
wiley   +1 more source

Multimodal Single-Cell Network Analysis Identifies Basigin/Cluster of Differentiation 147 as a Tumor-Associated Signaling Hub in Hepatocellular Carcinoma

Gastro Hep Advances
Background and Aims: Hepatocellular carcinoma (HCC) ranks among the leading causes of cancer mortality globally, driven by late diagnosis and inadequate sensitivity of biomarkers like α-fetoprotein for early or indeterminate lesions.
Thomas DW. Wang, Sangeeta Jaiswal, Eun-Young K. Choi, Shuo Feng, Hui Jiang, Thomas DS. Wang   +5 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, Volume 16, Issue 6, Page 1115-1131, June 2026.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Proteomics analysis of normal and senescent NG108-15 cells: GRP78 plays a negative role in cisplatin-induced senescence in the NG108-15 cell line. [PDF]

PLoS ONE, 2014
Accelerated senescence (ACS) leading to proliferative arrest is a physiological mechanism of the DNA damage response that occurs during tumor therapy. Our experiment was designed to detect unknown genes that may play important roles in cisplatin-induced ...
Wei Li, Wei Wang, Yan Li, Wenwen Wang, Tian Wang, Li Li, Zhiqiang Han, Shixuan Wang, Ding Ma, Hui Wang   +9 more
doaj   +1 more source

Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction.

Journal of Biological Chemistry, 1992
Cyclosporin A, the major immunosuppressive drug in transplantation, and the more potent therapeutic drug candidate, FK506, have led to the discovery of two superfamilies of immunosuppressant binding proteins, the cyclophilins and the FK binding proteins.
C T, Walsh, L D, Zydowsky, F D, McKeon
openaire   +2 more sources

The Regulation of Type 7 Adenylyl Cyclase by Its C1b Region and Escherichia coli Peptidylprolyl Isomerase, SlyD [PDF]

Journal of Biological Chemistry, 2001
Mammalian membrane-bound adenylyl cyclase consists of two highly conserved cytoplasmic domains (C1a and C2a) separated by a less conserved connecting region, C1b, and one of two transmembrane domains, M2. The C1a and C2a domains form a catalytic core that can be stimulated by forskolin and the stimulatory G protein subunit alpha (Galpha(s)).
S Z, Yan, J A, Beeler, Y, Chen, R K, Shelton, W J, Tang   +4 more
openaire   +2 more sources

Ocular surface disease in atopic dermatitis

Acta Ophthalmologica, Volume 104, Issue S291, Page S4-S28, June 2026.
ENGLISH SUMMARY Atopic keratoconjunctivitis (AKC) is a severe ocular surface disease (OSD) that significantly affects patients' quality of life and can lead to blindness. AKC is associated with atopic dermatitis (AD), a common chronic inflammatory skin disease affecting both children and adults.
Pernille May Hansen
wiley   +1 more source