Results 71 to 80 of about 7,181 (160)

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Ustilago maydis Phosphatidic Acid and Phosphatidylserine‐Targeting Secreted Lipase Lip3 Is Involved in Pathogenesis

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
Ustilago maydis secreted lipase, Lip3 targets PA and PS and alkalinises the host apoplast, thus promoting virulence. Loss of Lip3 results in reduced apoplastic pH and decreased pathogenicity. ABSTRACT Lipases constitute important virulence factors. By targeting specific lipids involved in various cellular processes, lipases regulate growth, development,
Anisha Roy, Rituparna Mondal, Anupama Ghosh   +2 more
wiley   +1 more source

Distinct fungal microbiomes of two Thai commercial stingless bee species, Lepidotrigona terminata and Tetragonula pagdeni suggest a possible niche separation in a shared habitat

Frontiers in Cellular and Infection Microbiology
Stingless bees, a social corbiculate bee member, play a crucial role in providing pollination services. Despite their importance, the structure of their microbiome, particularly the fungal communities, remains poorly understood.
Diana C. Castillo, Diana C. Castillo, Diana C. Castillo, Chainarong Sinpoo, Chainarong Sinpoo, Chainarong Sinpoo, Patcharin Phokasem, Patcharin Phokasem, Patcharin Phokasem, Rujipas Yongsawas, Rujipas Yongsawas, Chakriya Sansupa, Korrawat Attasopa, Korrawat Attasopa, Korrawat Attasopa, Nakarin Suwannarach, Nakarin Suwannarach, Nakarin Suwannarach, Sahutchai Inwongwan, Sahutchai Inwongwan, Sahutchai Inwongwan, Nuttapol Noirungsee, Nuttapol Noirungsee, Nuttapol Noirungsee, Terd Disayathanoowat, Terd Disayathanoowat, Terd Disayathanoowat   +26 more
doaj   +1 more source

Shortfalls in the peptidyl-prolyl cis–trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias

Neurobiology of Disease, 2004
The peptidyl-prolyl cis–trans isomerase (PPIase) Pin1 modulates the activity of a range of target proteins involved in the cell cycle, transcription, translation, endocytosis, and apoptosis by facilitating dephosphorylation of phosphorylated serine or ...
Julian R. Thorpe, Sabrina Mosaheb, Lida Hashemzadeh-Bonehi, Nigel J. Cairns, John E. Kay, Simon J. Morley, Stuart L. Rulten   +6 more
doaj   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, Volume 111, Issue 4, Page 2026-2043, 1 April 2026.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Ligand-based pharmacophore modelling, structure optimisation, and biological evaluation for the identification of 2-heteroarylthio-N-arylacetamides as novel HSP90 C-terminal inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry
Targeting Heat shock protein 90 (HSP90) C-terminus is an important strategy to develop HSP90 inhibitors without inducing heat shock response. The development of C-terminal inhibitors, however, is hampered by a lack of understanding regarding the ...
Yajun Liu, Chenyao Li, Yajing Li, Shuming Zhang, Ning Zhang, Xiaobo Bian, Shutao Tan   +6 more
doaj   +1 more source

Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease

Neural Plasticity, 2017
Synaptic loss is the structural basis for memory impairment in Alzheimer’s disease (AD). While the underlying pathological mechanism remains elusive, it is known that misfolded proteins accumulate as β-amyloid (Aβ) plaques and hyperphosphorylated Tau ...
Lingyan Xu, Zhiyun Ren, Frances E. Chow, Richard Tsai, Tongzheng Liu, Flavio Rizzolio, Silvia Boffo, Yungen Xu, Shaohui Huang, Carol F. Lippa, Yuesong Gong   +10 more
doaj   +1 more source

Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2017
Medulloblastoma is the most common malignant brain tumor in children. Therapeutic approaches to medulloblastoma (combination of surgery, radiotherapy, and chemotherapy) have led to significant improvements, but these are achieved at a high cost to ...
Tao Xu, Honglai Zhang, Sung-Soo Park, Sriram Venneti, Rork Kuick, Kimberly Ha, Lowell Evan Michael, Mariarita Santi, Chiyoko Uchida, Takafumi Uchida, Ashok Srinivasan, James M. Olson, Andrzej A. Dlugosz, Sandra Camelo-Piragua, Jean-François Rual   +14 more
doaj   +1 more source

Biological Actions of the Hsp90-binding Immunophilins FKBP51 and FKBP52

Biomolecules, 2019
Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-isomerase domain. High molecular weight immunophilins are characterized by the additional presence of tetratricopeptide-repeats (TPR) through which they bind to the 90 ...
Nadia R. Zgajnar, Sonia A. De Leo, Cecilia M. Lotufo, Alejandra G. Erlejman, Graciela Piwien-Pilipuk, Mario D. Galigniana   +5 more
doaj   +1 more source