Results 51 to 60 of about 7,181 (160)

MicroRNA-296-5p is differentially expressed in individuals with and without HIV-1 infection [PDF]

Genetics and Molecular Biology, 2020
MicroRNAs are considered as potential biomarkers, agents, or therapeutic targets; few studies have addressed the expression of miRNAs in treatment-naïve patients infected with HIV-1.
Jhonathan Cárdenas-Bedoya, Jazmin Marquez-Pedroza, María Cristina Morán-Moguel, Martha Escoto-Delgadillo, Eduardo Vázquez-Valls, Gracia Viviana González-Enríquez, Alma Minerva Pérez-Ríos, Blanca Miriam Torres-Mendoza   +7 more
doaj   +1 more source

Identification of Conus Peptidylprolyl Cis-Trans Isomerases (PPIases) and Assessment of Their Role in the Oxidative Folding of Conotoxins [PDF]

Journal of Biological Chemistry, 2010
Peptidylprolyl cis-trans isomerases (PPIases) are ubiquitous proteins that catalyze the cis-trans isomerization of prolines. A number of proteins, such as Drosophila rhodopsin and the human immunodeficiency viral protein HIV-1 Gag, have been identified as endogenous substrates for PPIases.
Helena, Safavi-Hemami, Grzegorz, Bulaj, Baldomero M, Olivera, Nicholas A, Williamson, Anthony W, Purcell   +4 more
openaire   +2 more sources

Piscirickettsiosis in Farmed Turbot, Scophthalmus maximus

Journal of Fish Diseases, Volume 49, Issue 9, September 2026.
ABSTRACT Piscirickettsia salmonis is a well‐established intracellular pathogen of farmed Atlantic salmon around the world. The bacterium has also been detected from a number of other hosts including lumpfish (Cyclopterus lumpus), seabass (Dicentrarchus labrax) and rainbow trout (Oncorhynchus mykiss).
Hanne K. Nilsen, Magne Kjerulf Hansen, Raoul Kuiper, Jan Inge Øvrebø, Kjersti Sturød, Maryam Saghafian, Snorre Gulla, Anne Berit Olsen, Duncan J. Colquhoun, Ole Bendik Dale   +9 more
wiley   +1 more source

Cyclophilin D in Mitochondrial Dysfunction: A Key Player in Neurodegeneration?

Biomolecules, 2023
Mitochondrial dysfunction plays a pivotal role in numerous complex diseases. Understanding the molecular mechanisms by which the “powerhouse of the cell” turns into the “factory of death” is an exciting yet challenging task that can unveil new ...
Gabriele Coluccino, Valentina Pia Muraca, Alessandra Corazza, Giovanna Lippe   +3 more
doaj   +1 more source

Specific Knockdown of Gene Expression in the Mature Rat Pineal Gland: The Cone‐Rod Homeodomain Transcription Factor Regulates Melatonin Synthesis In Vivo

Journal of Pineal Research, Volume 78, Issue 5, September 2026.
ABSTRACT Melatonin is synthesised from tryptophan by the sequential action of enzymes that are highly expressed in the pineal gland. Homeobox gene‐encoded transcription factors typically control organ development; however, a set of homeobox genes is strongly expressed in the adult pineal gland.
Nicole Anne Morrissey, Tenna Bering, Aurea Susana Blancas‐Velázquez, Jakob Albrethsen, Nicolai J. Wewer Albrechtsen, Martin Fredensborg Rath   +5 more
wiley   +1 more source

The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer.

PLoS ONE, 2013
In hormone receptor-positive breast cancers, most tumors in the early stages of development depend on the activity of the estrogen receptor and its ligand, estradiol. Anti-estrogens, such as tamoxifen, have been used as the first line of therapy for over
Chiara Lucchetti, Isabella Caligiuri, Giuseppe Toffoli, Antonio Giordano, Flavio Rizzolio   +4 more
doaj   +1 more source

Follicle Size Regulates Cytoplasmic Maturation, Lipid Content, and Embryo Cryosurvival in Bovine Oocytes Matured In‐Vitro

Molecular Reproduction and Development, Volume 93, Issue 8, August 2026.
Follicle size modulates bovine oocyte cytoplasmic maturation during IVM. Oocytes from larger follicles exhibit reduced lipid accumulation, fewer transzonal projections, distinct cumulus cell metabolic signaling, and greater embryo cryosurvival, indicating improved cytoplasmic maturation and lipid regulation despite similar developmental rates ...
Briza Castro, Paula Rodriguez‐Villamil, M. Sofia Ortega   +2 more
wiley   +1 more source

Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons. [PDF]

PLoS ONE, 2008
Mutations in ATCAY that encodes the brain-specific protein BNIP-H (or Caytaxin) lead to Cayman cerebellar ataxia. BNIP-H binds to glutaminase, a neurotransmitter-producing enzyme, and affects its activity and intracellular localization.
Jan Paul Buschdorf, Li Li Chew, Unice Jim Kim Soh, Yih-Cherng Liou, Boon Chuan Low   +4 more
doaj   +1 more source

Machine learning‐driven investigation on liquid–liquid phase separation‐related prognostic signature in diffuse large B‐cell lymphoma

British Journal of Haematology, Volume 209, Issue 2, Page 461-468, August 2026.
Summary Diffuse large B‐cell lymphoma (DLBCL) is the most common aggressive non‐Hodgkin lymphoma and is characterized by substantial heterogeneity. This study aimed to develop a liquid–liquid phase separation (LLPS)‐related prognostic model to improve risk stratification.
Zhen‐Zhong Zhou, Jia‐Chen Lu, Zhao Wang, Rong‐Hui Chen, Hai‐Long Li, Wan‐Ting Chen, Yu‐Ning Deng, Hui‐Juan Zhang, Yu Wang, Xuan‐Ye Zhang, Wei‐Juan Huang, Xiao‐Peng Tian   +11 more
wiley   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, Volume 49, Issue 8, Page 5849-5865, August 2026.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source