Results 51 to 60 of about 7,517 (194)

MicroRNA-150-5p inhibits the proliferation and invasion of human larynx epidermiod cancer cells though regulating peptidyl-prolyl cis/trans isomerase

Brazilian Journal of Otorhinolaryngology, 2023
Objective: This study aimed to investigate the molecular mechanism of miR-150-5p regulating the malignant biological behavior of Human Epidermoid cancer cell (HEp-2) by targeting peptidyl-prolyl cis/trans isomerase NIMA-Interacting-1 (PIN1).
Hailin Chen, Xuwei Cai, Baowen Du, Jianpiao Cai, Zhengzheng Luo   +4 more
doaj   +1 more source

Machine learning‐driven investigation on liquid–liquid phase separation‐related prognostic signature in diffuse large B‐cell lymphoma

British Journal of Haematology, EarlyView.
Summary Diffuse large B‐cell lymphoma (DLBCL) is the most common aggressive non‐Hodgkin lymphoma and is characterized by substantial heterogeneity. This study aimed to develop a liquid–liquid phase separation (LLPS)‐related prognostic model to improve risk stratification.
Zhen‐Zhong Zhou, Jia‐Chen Lu, Zhao Wang, Rong‐Hui Chen, Hai‐Long Li, Wan‐Ting Chen, Yu‐Ning Deng, Hui‐Juan Zhang, Yu Wang, Xuan‐Ye Zhang, Wei‐Juan Huang, Xiao‐Peng Tian   +11 more
wiley   +1 more source

Development of a contacting transwell co-culture system for the in vitro propagation of primary central nervous system lymphoma

Frontiers in Cell and Developmental Biology, 2023
Primary central nervous system lymphoma (PCNSL) is a malignant neoplasm of the central nervous system that is refractory to treatment and has extremely poor prognosis. One factor hindering the development of therapeutic options for PCNSL is its molecular
Mayuko Nishi, Mayuko Nishi, Kensuke Tateishi, Kensuke Tateishi, Jeremiah Stanleyraj Sundararaj, Yoko Ino, Yusuke Nakai, Yusuke Nakai, Yasuyoshi Hatayama, Yasuyoshi Hatayama, Yutaro Yamaoka, Yutaro Yamaoka, Yusaku Mihana, Yusaku Mihana, Kei Miyakawa, Kei Miyakawa, Hirokazu Kimura, Yayoi Kimura, Tetsuya Yamamoto, Akihide Ryo, Akihide Ryo   +20 more
doaj   +1 more source

MicroRNA-296-5p is differentially expressed in individuals with and without HIV-1 infection [PDF]

Genetics and Molecular Biology, 2020
MicroRNAs are considered as potential biomarkers, agents, or therapeutic targets; few studies have addressed the expression of miRNAs in treatment-naïve patients infected with HIV-1.
Jhonathan Cárdenas-Bedoya, Jazmin Marquez-Pedroza, María Cristina Morán-Moguel, Martha Escoto-Delgadillo, Eduardo Vázquez-Valls, Gracia Viviana González-Enríquez, Alma Minerva Pérez-Ríos, Blanca Miriam Torres-Mendoza   +7 more
doaj   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Membrane Permeable Cyclic Peptidyl Inhibitors against Human Peptidylprolyl Isomerase Pin1

, 2016
Peptidylprolyl isomerase Pin1 regulates the function and/or stability of phosphoproteins by altering the conformation of specific pSer/pThr-Pro peptide bonds.
Tao Liu (10785), Hung-Ying Kao (399145), Yu Liu (6938), Dehua Pei (357696)   +3 more
core   +1 more source

Cyclophilin D in Mitochondrial Dysfunction: A Key Player in Neurodegeneration?

Biomolecules, 2023
Mitochondrial dysfunction plays a pivotal role in numerous complex diseases. Understanding the molecular mechanisms by which the “powerhouse of the cell” turns into the “factory of death” is an exciting yet challenging task that can unveil new ...
Gabriele Coluccino, Valentina Pia Muraca, Alessandra Corazza, Giovanna Lippe   +3 more
doaj   +1 more source

Neutrophil Secretory Proteins Inhibit Calcium Oxalate Crystallisation and Crystal Growth, but Promote Crystal Aggregation

Immunology, EarlyView.
Calcium oxalate monohydrate (COM) crystals cause changes in the secretion of 29 proteins from neutrophil‐like cells, including those involved in neutrophil immune activation and intracellular metabolic adaptation. The neutrophil secreted proteins (secretome) also inhibit calcium oxalate crystallisation and crystal growth, but promote crystal ...
Chanettee Lertprapai, Paleerath Peerapen, Visith Thongboonkerd   +2 more
wiley   +1 more source

The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer.

PLoS ONE, 2013
In hormone receptor-positive breast cancers, most tumors in the early stages of development depend on the activity of the estrogen receptor and its ligand, estradiol. Anti-estrogens, such as tamoxifen, have been used as the first line of therapy for over
Chiara Lucchetti, Isabella Caligiuri, Giuseppe Toffoli, Antonio Giordano, Flavio Rizzolio   +4 more
doaj   +1 more source

Identification of Conus Peptidylprolyl Cis-Trans Isomerases (PPIases) and Assessment of Their Role in the Oxidative Folding of Conotoxins [PDF]

Journal of Biological Chemistry, 2010
Peptidylprolyl cis-trans isomerases (PPIases) are ubiquitous proteins that catalyze the cis-trans isomerization of prolines. A number of proteins, such as Drosophila rhodopsin and the human immunodeficiency viral protein HIV-1 Gag, have been identified as endogenous substrates for PPIases.
Helena, Safavi-Hemami, Grzegorz, Bulaj, Baldomero M, Olivera, Nicholas A, Williamson, Anthony W, Purcell   +4 more
openaire   +2 more sources