Resolving the functions of peptidylprolyl isomerases: insights from the mutagenesis of the nuclear FKBP25 enzyme [PDF]
Biochemical Society Transactions, 2013 Peptidylprolyl isomerases have been implicated in chromatin regulation through their association with histones, chromatin-modifying enzymes and DNA-binding transcription factors. As with other post-translational modifications to proteins, a mechanistic understanding of the regulation of biological processes is fostered by loss-of-function studies both ...
Geoff, Gudavicius +5 more
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Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing
Nature Communications, 2018 Nuclear factor-kappa B (NF-κB) signaling is regulated by ubiquitin to maintain immune homeostasis. Here the authors show that a peptidylprolyl isomerase, CYPJ, blocks TAB2/3 or LUBAC ubiquitin chain sensing and suppress NF-κB activation, with CYPJ ...
Chunjie Sheng +8 more
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Introduction to Peptidyl-Prolyl cis/trans Isomerase (PPIase) Series
Biomolecules, 2019 About 30 years after the discovery of peptidyl-prolyl cis/trans isomerases (PPIases), research on this group of proteins has become somewhat calmer than it used to be, but it still generates lots of interest [...]
Andrzej Galat
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Membrane Permeable Cyclic Peptidyl Inhibitors against Human Peptidylprolyl Isomerase Pin1 [PDF]
Journal of Medicinal Chemistry, 2010 Peptidylprolyl isomerase Pin1 regulates the function and/or stability of phosphoproteins by altering the conformation of specific pSer/pThr-Pro peptide bonds. In this work, a cyclic peptide library was synthesized and screened against the catalytic domain of human Pin1. The selected inhibitors contained a consensus motif of D-pThr-Pip-Nal (where Pip is
Tao, Liu +3 more
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Role of Periplasmic Peptidylprolyl Isomerases in Salmonella enterica Serovar Typhimurium Virulence [PDF]
Infection and Immunity, 2003 ABSTRACT FkpA is a peptidylprolyl isomerase whose expression is regulated by the alternative sigma factor, sigma factor E (σ E ). In contrast to the results of a previous report, inactivation of fkpA was found to have only a minor effect on the ability of Salmonella ...
Humphreys, Sue +5 more
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Identification of heat shock protein70-2 and protamine-1 mRNA, proteins, and analyses of their association with fertility using frozen-thawed sperm in Madura bulls [PDF]
Animal Bioscience, 2023 Objective This study aims to identify heat shock protein70-2 (HSP70-2) and protamine-1 (PRM1) mRNA and protein in Madura bull sperm and demonstrate their relation as bull fertility biomarkers. Methods The Madura bull fertility rates were grouped based on
Zulfi Nur Amrina Rosyada +6 more
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Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities [PDF]
Biomolecules, 2017 Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overall hydrophobicity indexes vary within a considerable level whereas their points isoelectric (pIs) are ...
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Bioinformatics analysis and experimental validation of tumorigenic role of PPIA in gastric cancer
Scientific Reports, 2023 Gastric cancer (GC) is a malignant tumor with high incidence rate and mortality. Due to the lack of effective diagnostic indicators, most patients are diagnosed in late stage and have a poor prognosis.
Jichao Liu +3 more
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Plant organelles contain distinct peptidylprolyl cis,trans-isomerases.
Journal of Biological Chemistry, 1992 Peptidylprolyl cis,trans-isomerase (PPIase) activity was detected in the cytosol, mitochondria, and chloroplast of pea plants. Cyclosporin A inhibited the activity largely localized to the mitochondrial matrix while rapamycin inhibited the PPIase activity associated with the mitochondrial membranes.
A, Breiman +3 more
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Cyclophilin J PPIase Inhibitors Derived from 2,3-Quinoxaline-6 Amine Exhibit Antitumor Activity
Frontiers in Pharmacology, 2018 Cyclophilin J (CyPJ), also called peptidylprolyl isomerase like 3, has been identified as a novel member of the cyclophilin family. Our previous research has resolved the three-dimensional structure of CyPJ and demonstrated the peptidylprolyl cis–trans ...
Xuemei Zhao +7 more
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