Results 31 to 40 of about 7,517 (194)

Loss of secretory pathway FK506-binding proteins results in cold-sensitive lethality in caenorhabditis elegans [PDF]

, 2007
The FK506-binding proteins (FKBs) represent ubiquitous enzymes that catalyse the rate-limiting peptidyl prolyl cis-trans isomerization step in protein folding. The nematode <i>Caenorhabditis elegans</i> has eight FKBs, three of which (FKB-3, -
Page, Antony P., Eschenlauer, SCP, McCormack, Gillian, Winter, AD, Page, AP, Eschenlauer, Sylvain C. P., McCormack, G, Winter, Alan D.   +7 more
core   +1 more source

Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war

Nature Communications, 2020
Cyclophilin A (CypA) is a peptidylprolyl isomerase that also has chaperone activity and interacts with the intrinsically disordered protein α-Synuclein (aSyn).
Filippo Favretto, David Flores, Jeremy D. Baker, Timo Strohäker, Loren B. Andreas, Laura J. Blair, Stefan Becker, Markus Zweckstetter   +7 more
doaj   +1 more source

Non-Catalytic Participation of the Pin1 Peptidyl-Prolyl Isomerase Domain in Target Binding

Frontiers in Physiology, 2013
Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase that has the potential to add an additional level of regulation within protein kinase mediated signaling pathways.
Brendan Tooke Innes, Melanie L. Bailey, Christopher J Brandl, Brian H. Shilton, David William Litchfield   +4 more
doaj   +1 more source

Sensory nerves directly promote osteoclastogenesis by secreting peptidyl-prolyl cis-trans isomerase D (Cyp40)

Bone Research, 2023
Given afferent functions, sensory nerves have recently been found to exert efferent effects and directly alter organ physiology. Additionally, several studies have highlighted the indirect but crucial role of sensory nerves in the regulation of the ...
Junqin Li, Bin Liu, Hao Wu, Shuaishuai Zhang, Zhuowen Liang, Shuo Guo, Huijie Jiang, Yue Song, Xing Lei, Yi Gao, Pengzhen Cheng, Donglin Li, Jimeng Wang, Yang Liu, Di Wang, Nazhi Zhan, Jing Xu, Lin Wang, Guozhi Xiao, Liu Yang, GuoXian Pei   +20 more
doaj   +1 more source

Resolving the functions of peptidylprolyl isomerases: insights from the mutagenesis of the nuclear FKBP25 enzyme [PDF]

Biochemical Society Transactions, 2013
Peptidylprolyl isomerases have been implicated in chromatin regulation through their association with histones, chromatin-modifying enzymes and DNA-binding transcription factors. As with other post-translational modifications to proteins, a mechanistic understanding of the regulation of biological processes is fostered by loss-of-function studies both ...
Geoff, Gudavicius, Heddy, Soufari, Santosh Kumar, Upadhyay, Santosh, Upadhyay, Cameron D, Mackereth, Christopher J, Nelson   +5 more
openaire   +2 more sources

Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing

Nature Communications, 2018
Nuclear factor-kappa B (NF-κB) signaling is regulated by ubiquitin to maintain immune homeostasis. Here the authors show that a peptidylprolyl isomerase, CYPJ, blocks TAB2/3 or LUBAC ubiquitin chain sensing and suppress NF-κB activation, with CYPJ ...
Chunjie Sheng, Chen Yao, Ziyang Wang, Hongyuan Chen, Yu Zhao, Dazhi Xu, Haojie Huang, Wenlin Huang, Shuai Chen   +8 more
doaj   +1 more source

Introduction to Peptidyl-Prolyl cis/trans Isomerase (PPIase) Series

Biomolecules, 2019
About 30 years after the discovery of peptidyl-prolyl cis/trans isomerases (PPIases), research on this group of proteins has become somewhat calmer than it used to be, but it still generates lots of interest [...]
Andrzej Galat
doaj   +1 more source

Membrane Permeable Cyclic Peptidyl Inhibitors against Human Peptidylprolyl Isomerase Pin1 [PDF]

Journal of Medicinal Chemistry, 2010
Peptidylprolyl isomerase Pin1 regulates the function and/or stability of phosphoproteins by altering the conformation of specific pSer/pThr-Pro peptide bonds. In this work, a cyclic peptide library was synthesized and screened against the catalytic domain of human Pin1. The selected inhibitors contained a consensus motif of D-pThr-Pip-Nal (where Pip is
Tao, Liu, Yu, Liu, Hung-Ying, Kao, Dehua, Pei   +3 more
openaire   +2 more sources

Role of Periplasmic Peptidylprolyl Isomerases in Salmonella enterica Serovar Typhimurium Virulence [PDF]

Infection and Immunity, 2003
ABSTRACT FkpA is a peptidylprolyl isomerase whose expression is regulated by the alternative sigma factor, sigma factor E (σ E ). In contrast to the results of a previous report, inactivation of fkpA was found to have only a minor effect on the ability of Salmonella ...
Humphreys, Sue, Rowley, Gary, Stevenson, Andrew, Kenyon, William J., Spector, Michael P., Roberts, Mark   +5 more
openaire   +3 more sources

Identification of heat shock protein70-2 and protamine-1 mRNA, proteins, and analyses of their association with fertility using frozen-thawed sperm in Madura bulls [PDF]

Animal Bioscience, 2023
Objective This study aims to identify heat shock protein70-2 (HSP70-2) and protamine-1 (PRM1) mRNA and protein in Madura bull sperm and demonstrate their relation as bull fertility biomarkers. Methods The Madura bull fertility rates were grouped based on
Zulfi Nur Amrina Rosyada, Berlin Pandapotan Pardede, Ekayanti Mulyawati Kaiin, Ligaya I.T.A Tumbelaka, Dedy Duryadi Solihin, Bambang Purwantara, Mokhamad Fakhrul Ulum   +6 more
doaj   +1 more source