Results 21 to 30 of about 7,181 (160)

Distribution of Peptidyl-Prolyl Isomerase (PPIase) in the Archaea

Frontiers in Microbiology, 2021
Cis-trans isomerization of the peptide bond prior to proline is an intrinsically slow process but plays an essential role in protein folding. In vivo cis-trans isomerization reaction is catalyzed by Peptidyl-prolyl isomerase (PPIases), a category of ...
Anchal, Vineeta Kaushik, Manisha Goel
doaj   +1 more source

Involvement of Peptidylprolyl cis / trans Isomerases in Enterococcus faecalis Virulence [PDF]

Infection and Immunity, 2012
ABSTRACT Peptidylprolyl cis / trans isomerases (PPIases) are enzymes involved in protein folding. Analysis of the genome sequence of Enterococcus faecalis V583 allowed for identification of 3 PPIases carrying genes.
Reffuveille, Fany, Connil, Nathalie, Sanguinetti, Maurizio, Posteraro, Brunella, Chevalier, Sylvie, Auffray, Yanick, Rince, Alain, Camilli, A.   +7 more
openaire   +3 more sources

Proteomics and metabolomics analyses of camptothecin-producing Aspergillus terreus reveal the integration of PH domain-containing proteins and peptidylprolyl cis/trans isomerase in restoring the camptothecin biosynthesis

Microbiology Spectrum, 2023
Attenuating the expression of fungal camptothecin biosynthetic genes with subculturing is the challenge that halts their further implementation. The camptothecin productivity of the subcultured Aspergillus terreus has been restored upon addition of Ficus
Amgad M. Rady, Ashraf S. A. El-Sayed, Ashraf F. El-Baz, Ghada G. Abdel-Fattah, Sameh Magdeldin, Eman Ahmed, Aya Osama, Sameh E. Hassanein, Hend Saed, Marwa Yassin   +9 more
doaj   +1 more source

Post-translational Modifications of the Peptidyl-Prolyl Isomerase Pin1

Frontiers in Cell and Developmental Biology, 2020
The peptidyl-prolyl cis/trans isomerase (PPIase) Pin1 is a unique enzyme that only binds to Ser/Thr-Pro peptide motifs after phosphorylation and regulates the conformational changes of the bond.
Dongmei Chen, Long Wang, Tae Ho Lee
doaj   +1 more source

Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer’s Disease

Frontiers in Cell and Developmental Biology, 2020
Alzheimer’s disease (AD) is the most common cause of dementia with cognitive decline. The neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles consisting of hyperphosphorylated tau and extracellular deposition of ...
Long Wang, Ying Zhou, Ying Zhou, Dongmei Chen, Tae Ho Lee   +4 more
doaj   +1 more source

Housekeeping gene expression variability in differentiating and non-differentiating 3T3-L1 cells

Adipocyte, 2023
Normalization is a crucial step in gene expression analysis to avoid misinterpretation. Reverse transcription-quantitative polymerase chain reaction was used to measure the expression of 10 candidate housekeeping genes in non-differentiated (ND) and ...
Danang Dwi Cahyadi, Tomoko Warita, Nanami Irie, Kana Mizoguchi, Jiro Tashiro, Yoshinao Z. Hosaka, Katsuhiko Warita   +6 more
doaj   +1 more source

Identification of stable normalization genes for quantitative real-time PCR in porcine articular cartilage

Journal of Animal Science and Biotechnology, 2012
Background Expression levels for genes of interest must be normalized with an appropriate reference, or housekeeping gene, to make accurate comparisons of quantitative real-time PCR results.
McCulloch Ryan S, Ashwell Melissa S, O’Nan Audrey T, Mente Peter L   +3 more
doaj   +1 more source

The role of peptidyl-prolyl isomerase Pin1 in neuronal signaling in epilepsy

Frontiers in Molecular Neuroscience, 2022
Epilepsy is a common symptom of many neurological disorders and can lead to neuronal damage that plays a major role in seizure-related disability.
Yuwen Chen, Xiaojun Hou, Xiaojun Hou, Jiao Pang, Fan Yang, Fan Yang, Angcheng Li, Suijin Lin, Na Lin, Tae Ho Lee, Hekun Liu   +10 more
doaj   +1 more source

Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war

Nature Communications, 2020
Cyclophilin A (CypA) is a peptidylprolyl isomerase that also has chaperone activity and interacts with the intrinsically disordered protein α-Synuclein (aSyn).
Filippo Favretto, David Flores, Jeremy D. Baker, Timo Strohäker, Loren B. Andreas, Laura J. Blair, Stefan Becker, Markus Zweckstetter   +7 more
doaj   +1 more source

Sensory nerves directly promote osteoclastogenesis by secreting peptidyl-prolyl cis-trans isomerase D (Cyp40)

Bone Research, 2023
Given afferent functions, sensory nerves have recently been found to exert efferent effects and directly alter organ physiology. Additionally, several studies have highlighted the indirect but crucial role of sensory nerves in the regulation of the ...
Junqin Li, Bin Liu, Hao Wu, Shuaishuai Zhang, Zhuowen Liang, Shuo Guo, Huijie Jiang, Yue Song, Xing Lei, Yi Gao, Pengzhen Cheng, Donglin Li, Jimeng Wang, Yang Liu, Di Wang, Nazhi Zhan, Jing Xu, Lin Wang, Guozhi Xiao, Liu Yang, GuoXian Pei   +20 more
doaj   +1 more source