A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulence. [PDF]
Infect Immun, 2011 Macrophage infectivity potentiators (Mips) are a group of virulence factors encoded by pathogenic bacteria such as Legionella, Chlamydia, and Neisseria species.
Norville IH +7 more
europepmc +3 more sources
The Peptidylprolyl cis/trans-Isomerase Pin1 Modulates Stress-induced Dephosphorylation of Tau in Neurons [PDF]
Journal of Biological Chemistry, 2006 Deregulation of Tau phosphorylation is a key question in Alzheimer disease pathogenesis. Recently, Pin1, a peptidylprolyl cis/trans-isomerase, was proposed to be a new modulator in Tau phosphorylation in Alzheimer disease.
Marie-Christine Galas +6 more
openaire +2 more sources
Regulation of Bruton Tyrosine Kinase by the Peptidylprolyl Isomerase Pin1 [PDF]
Journal of Biological Chemistry, 2006 Bruton tyrosine kinase (Btk) is expressed in B-lymphocytes. Mutations in Btk cause X-linked agammaglobulinemia in humans. However, the mechanism of activation and signaling of this enzyme has not been fully investigated. We have here shown that the peptidylprolyl cis/trans isomerase (PPIase) Pin1 is a negative regulator of Btk, controlling its ...
Liang, Yu +6 more
openaire +2 more sources
Distribution of Peptidyl-Prolyl Isomerase (PPIase) in the Archaea
Frontiers in Microbiology, 2021 Cis-trans isomerization of the peptide bond prior to proline is an intrinsically slow process but plays an essential role in protein folding. In vivo cis-trans isomerization reaction is catalyzed by Peptidyl-prolyl isomerase (PPIases), a category of ...
Anchal, Vineeta Kaushik, Manisha Goel
doaj +1 more source
Involvement of Peptidylprolyl cis / trans Isomerases in Enterococcus faecalis Virulence [PDF]
Infection and Immunity, 2012 ABSTRACT Peptidylprolyl cis / trans isomerases (PPIases) are enzymes involved in protein folding. Analysis of the genome sequence of Enterococcus faecalis V583 allowed for identification of 3 PPIases carrying genes.
Reffuveille, Fany +7 more
openaire +3 more sources
Microbiology Spectrum, 2023 Attenuating the expression of fungal camptothecin biosynthetic genes with subculturing is the challenge that halts their further implementation. The camptothecin productivity of the subcultured Aspergillus terreus has been restored upon addition of Ficus
Amgad M. Rady +9 more
doaj +1 more source
Post-translational Modifications of the Peptidyl-Prolyl Isomerase Pin1
Frontiers in Cell and Developmental Biology, 2020 The peptidyl-prolyl cis/trans isomerase (PPIase) Pin1 is a unique enzyme that only binds to Ser/Thr-Pro peptide motifs after phosphorylation and regulates the conformational changes of the bond.
Dongmei Chen, Long Wang, Tae Ho Lee
doaj +1 more source
Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer’s Disease
Frontiers in Cell and Developmental Biology, 2020 Alzheimer’s disease (AD) is the most common cause of dementia with cognitive decline. The neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles consisting of hyperphosphorylated tau and extracellular deposition of ...
Long Wang +4 more
doaj +1 more source
Housekeeping gene expression variability in differentiating and non-differentiating 3T3-L1 cells
Adipocyte, 2023 Normalization is a crucial step in gene expression analysis to avoid misinterpretation. Reverse transcription-quantitative polymerase chain reaction was used to measure the expression of 10 candidate housekeeping genes in non-differentiated (ND) and ...
Danang Dwi Cahyadi +6 more
doaj +1 more source
The role of peptidyl-prolyl isomerase Pin1 in neuronal signaling in epilepsy
Frontiers in Molecular Neuroscience, 2022 Epilepsy is a common symptom of many neurological disorders and can lead to neuronal damage that plays a major role in seizure-related disability.
Yuwen Chen +10 more
doaj +1 more source