Peptidylprolyl Isomerase Pin1 Directly Enhances the DNA Binding Functions of Estrogen Receptor α. [PDF]
J Biol Chem, 2015 The transcriptional activity of estrogen receptor α (ERα), the key driver of breast cancer proliferation, is enhanced by multiple cellular interactions, including phosphorylation-dependent interaction with Pin1, a proline isomerase, which mediates cis-trans isomerization of the N-terminal Ser(P)(118)-Pro(119) in the intrinsically disordered AF1 ...
Rajbhandari P +4 more
europepmc +4 more sources
Upregulated Hexokinase-2 in Airway Epithelium Regulates Apoptosis and Drives Inflammation in Asthma via Peptidylprolyl Isomerase F [PDF]
CellsHexokinase catalyzes the first rate-limiting step glycolysis. However, the roles of hexokinase 2 (HK2) in asthma remain incompletely understood. This study aimed to investigate metabolic alterations in asthma, focusing on the expression, function and ...
Zhen Tian +9 more
doaj +2 more sources
miRNA-192-5p impacts the sensitivity of breast cancer cells to doxorubicin via targeting peptidylprolyl isomerase A. [PDF]
Kaohsiung J Med Sci, 2019 The administration of doxorubicin (DOX) is one of the first‐line treatments of breast cancer. However, acquisition of resistance remains the major obstacle restricting the clinical application of DOX. MicroRNAs (miRNAs) are small, noncoding RNAs which play crucial role in epigenetic regulation.
Zhang Y +7 more
europepmc +4 more sources
Non-catalytic participation of the Pin1 peptidyl-prolyl isomerase domain in target binding
Frontiers in Physiology, 2013 Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase that has the potential to add an additional level of regulation within protein kinase mediated signaling pathways.
Brian Shilton +2 more
exaly +3 more sources
Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes [PDF]
Brain, 2015 Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A, is a multifunctional protein with peptidyl-prolyl cis-trans isomerase activity. PPIA is also a translational biomarker for amyotrophic lateral sclerosis, and is enriched in aggregates isolated from amyotrophic lateral sclerosis and frontotemporal lobar degeneration patients.
Silvia Pozzi +2 more
exaly +3 more sources
Cyclophilin-A Is Bound through Its Peptidylprolyl Isomerase Domain to the Cytoplasmic Dynein Motor Protein Complex [PDF]
Journal of Biological Chemistry, 2004 Although cyclophilin A (CyP-A) is a relatively abundant small immunophilin present in the cytoplasm of all mammalian cells, its general function(s) in the absence of the immunosuppressant drug cyclosporin A is not known. In contrast, the high molecular weight hsp90-binding immunophilins appear to play a role in protein trafficking in that they have ...
Philippe Gallay +2 more
exaly +6 more sources
Interplay between acute Type A aortic dissection and pan-cancer: Clinical evidence, bioinformatics, and experimental validation [PDF]
iScienceSummary: Acute Type A Aortic Dissection (ATAAD) and cancer represent major global health burdens, yet shared mechanisms remain elusive. Epidemiological analyses linked ATAAD to increased risks of lung adenocarcinoma (LUAD) and head and neck squamous cell
Fangshun Tan +9 more
doaj +2 more sources
The Periplasmic Escherichia coli Peptidylprolyl cis,trans-Isomerase FkpA [PDF]
Journal of Biological Chemistry, 2000 We recently identified FkpA by selecting for the increased yield of antibody single-chain Fv (scFv) fragments in phage display, even of those not containing cis-prolines. We have now investigated the properties of FkpA in vitro. The peptidylprolyl cis-trans-isomerase activity of FkpA was found to be among the highest of any such enzyme with a protein ...
Kathrin Ramm, Andreas Plückthun
openaire +5 more sources
Exploring Reaction Pathways for Peptidylprolyl-Isomerase [PDF]
Biophysical Journal, 2017 Pin1 enzyme is one of the peptidyl-prolyl cis/trans isomerases (PPIase), which isomerizes an omega bond of specific phospho-Serine/Threonine-Proline motifs, leading to many biological consequences. However, the isomerization mechanism has not been fully clarified yet though there are several experimental and numerical studies.
Hiroshi Fujisaki +4 more
openaire +1 more source
Regulation of Bruton Tyrosine Kinase by the Peptidylprolyl Isomerase Pin1 [PDF]
Journal of Biological Chemistry, 2006 Bruton tyrosine kinase (Btk) is expressed in B-lymphocytes. Mutations in Btk cause X-linked agammaglobulinemia in humans. However, the mechanism of activation and signaling of this enzyme has not been fully investigated. We have here shown that the peptidylprolyl cis/trans isomerase (PPIase) Pin1 is a negative regulator of Btk, controlling its ...
Liang, Yu +6 more
openaire +2 more sources