Results 41 to 50 of about 7,517 (194)

Bioinformatics analysis and experimental validation of tumorigenic role of PPIA in gastric cancer

Scientific Reports, 2023
Gastric cancer (GC) is a malignant tumor with high incidence rate and mortality. Due to the lack of effective diagnostic indicators, most patients are diagnosed in late stage and have a poor prognosis.
Jichao Liu, Yanjun Wang, Zhiwei Zhao, Yanhui Ge   +3 more
doaj   +1 more source

Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities [PDF]

Biomolecules, 2017
Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overall hydrophobicity indexes vary within a considerable level whereas their points isoelectric (pIs) are ...
openaire   +3 more sources

Single nucleotide polymorphisms of PIN1 promoter region and cancer risk: evidence from a meta-analysis. [PDF]

PLoS ONE, 2013
Peptidylprolyl cis/trans isomerase NIMA-interacting 1 (PIN1) is involved in the process of tumorigenesis. The two single nucleotide polymorphisms (-677T>C, -842G>C) in the PIN1 promoter region have been suspected of being associated with cancer risk for ...
Jing-Jing Peng, Dong Wei, Dong Li, Zeng-Qiang Fu, Yong Tan, Tao Xu, Jing-Jun Zhou, Tao Zhang   +7 more
doaj   +1 more source

Plant organelles contain distinct peptidylprolyl cis,trans-isomerases.

Journal of Biological Chemistry, 1992
Peptidylprolyl cis,trans-isomerase (PPIase) activity was detected in the cytosol, mitochondria, and chloroplast of pea plants. Cyclosporin A inhibited the activity largely localized to the mitochondrial matrix while rapamycin inhibited the PPIase activity associated with the mitochondrial membranes.
A, Breiman, T W, Fawcett, M L, Ghirardi, A K, Mattoo   +3 more
openaire   +2 more sources

Cyclophilin J PPIase Inhibitors Derived from 2,3-Quinoxaline-6 Amine Exhibit Antitumor Activity

Frontiers in Pharmacology, 2018
Cyclophilin J (CyPJ), also called peptidylprolyl isomerase like 3, has been identified as a novel member of the cyclophilin family. Our previous research has resolved the three-dimensional structure of CyPJ and demonstrated the peptidylprolyl cis–trans ...
Xuemei Zhao, Chengcai Xia, Xiaodan Wang, Hao Wang, Ming Xin, Long Yu, Yulong Liang, Yulong Liang   +7 more
doaj   +1 more source

Pinning Down the Transcription: A Role for Peptidyl-Prolyl cis-trans Isomerase Pin1 in Gene Expression

Frontiers in Cell and Developmental Biology, 2020
Pin1 is a peptidyl-prolyl cis-trans isomerase that specifically binds to a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif and catalyzes the cis-trans isomerization of proline imidic peptide bond, resulting in ...
Xiangming Hu, Lin-Feng Chen, Lin-Feng Chen   +2 more
doaj   +1 more source

Characterization of Peptidyl-Prolyl Cis-Trans Isomerase- and Calmodulin-Binding Activity of a Cytosolic Arabidopsis thaliana Cyclophilin AtCyp19-3. [PDF]

PLoS ONE, 2015
Cyclophilins, which bind to immunosuppressant cyclosporin A (CsA), are ubiquitous proteins and constitute a multigene family in higher organisms. Several members of this family are reported to catalyze cis-trans isomerisation of the peptidyl-prolyl bond,
Gundeep Kaur, Supreet Singh, Harpreet Singh, Mrinalini Chawla, Tanima Dutta, Harsimran Kaur, Kyle Bender, W A Snedden, Sanjay Kapoor, Ashwani Pareek, Prabhjeet Singh   +10 more
doaj   +1 more source

Cyclophilin J is a novel peptidyl-prolyl isomerase and target for repressing the growth of hepatocellular carcinoma. [PDF]

PLoS ONE, 2015
Cyclophilin J (CYPJ) is a new member of the peptidyl-prolyl cis/trans-isomerase (PPIase) identified with upregulated expression in human glioma. However, the biological function of CYPJ remained unclear.
Jian Chen, Shuai Chen, Jiahui Wang, Mingjun Zhang, Zhaohua Gong, Youheng Wei, Li Li, Yuanyuan Zhang, Xuemei Zhao, Songmin Jiang, Long Yu   +10 more
doaj   +1 more source

Lung Cancer Patients Display Increased Expression of Bovine Meat and Milk Factor (BMMF) Proteins in Peritumor Alveolar Macrophages

International Journal of Cancer, EarlyView.
Plasmid‐like DNA sequences frequently found in bovine milk and serum have been proposed as infectious agents promoting indirect carcinogenesis. This multi‐omics study detected immune cells positive for these bovine meat and milk factors (BMMFs) in patients with lung cancer, with BMMF expression inversely correlated with smoking intensity.
Nives Cecere, Kristina Alikhanyan, Claudia Ernst, Lisa Häfele, Lars Feuerbach, Imke Grewe, Sumen Siqin, Karin Gunst, Gunjan Shukla, Veronika Frehtman, Claudia Tessmer, Florian Eichhorn, Michael Allgäuer, Alexander Brobeil, Ilse Hofmann, Barbara Leuchs, Marc A. Schneider, Timo Bund   +17 more
wiley   +1 more source

Interaction of the periplasmic peptidylprolyl cis-trans isomerase SurA with model peptides. The N-terminal region of SurA id essential and sufficient for peptide binding.

, 2001
One of the rate-limiting steps in protein folding has been shown to be the cis-trans isomerization of proline residues, which is catalyzed by a range of peptidylprolyl cis-trans isomerases.
Helen Webb (5178887), Klappa, Peter, Rosalyn J Marchant (16294646), Peter Klappa (16294649), Marchant, Rosalyn J., Lloyd W Ruddock (16294643), Webb, Helen M., Ruddock, Lloyd W., Kim Jonas (3525977), Jonas, Kim   +9 more
core   +1 more source