Results 121 to 130 of about 11,623 (233)
Journal of Enzyme Inhibition and Medicinal ChemistryTargeting Heat shock protein 90 (HSP90) C-terminus is an important strategy to develop HSP90 inhibitors without inducing heat shock response. The development of C-terminal inhibitors, however, is hampered by a lack of understanding regarding the ...
Yajun Liu +6 more
doaj +1 more source
Neural Plasticity, 2017 Synaptic loss is the structural basis for memory impairment in Alzheimer’s disease (AD). While the underlying pathological mechanism remains elusive, it is known that misfolded proteins accumulate as β-amyloid (Aβ) plaques and hyperphosphorylated Tau ...
Lingyan Xu +10 more
doaj +1 more source
Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis
Neoplasia: An International Journal for Oncology Research, 2017 Medulloblastoma is the most common malignant brain tumor in children. Therapeutic approaches to medulloblastoma (combination of surgery, radiotherapy, and chemotherapy) have led to significant improvements, but these are achieved at a high cost to ...
Tao Xu +14 more
doaj +1 more source
The Journal of Physiology, Volume 603, Issue 24, Page 7731-7750, December 15, 2025.Abstract figure legend The human gut microbiome remains stable in the face of an intensive energy restriction and vigorous‐intensity exercise intervention that improved body composition and metabolic health in people with overweight/obesity. Thus, early metabolic changes with weight loss in humans are unlikely to be mediated by changes to the gut ...
Russell G. Davies +15 more
wiley +1 more source
Biological Actions of the Hsp90-binding Immunophilins FKBP51 and FKBP52
Biomolecules, 2019 Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-isomerase domain. High molecular weight immunophilins are characterized by the additional presence of tetratricopeptide-repeats (TPR) through which they bind to the 90 ...
Nadia R. Zgajnar +5 more
doaj +1 more source
Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation [PDF]
, 2018 This is the final version of the article. Available from Elsevier via the DOI in this record.Bacterial lipoproteins are surface exposed, anchored to the membrane by S-diacylglyceryl modification of the N-terminal cysteine thiol. They play important roles
Charlton, TM +4 more
core +1 more source
FASEB BioAdvances, Volume 7, Issue 11, November 2025.Folic acid supplementation to high‐fat diets reduced hepatic steatosis in male C57BL/6J mice, as evidenced by lower triacylglycerol (TAG) levels in the liver. These effects were associated with increased hepatic choline availability, upregulation of choline‐metabolizing genes, and alterations in the hepatic fatty acid profile, suggestive of suppressed ...
Eva Kranenburg +8 more
wiley +1 more source
Toxins, 2019 Peptidyl-prolyl cis/trans isomerases (PPIases) are enzymes that catalyze the cis-to-trans isomerization around proline bonds, allowing proteins to fold into their correct confirmation. Previously, we identified two PPIase enzymes in Staphylococcus aureus
Rebecca A. Keogh +5 more
doaj +1 more source
Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI [PDF]
, 2017 OBJECTIVES We aimed to investigate whether apparent diffusion coefficients (ADCs) measured by 3.0T diffusion-weighted magnetic resonance imaging (DWI) associate with histological aggressiveness of ovarian cancer (OC) or predict the clinical outcome ...
Annukka Kivelä +11 more
core +1 more source
Chaperone patterns in vernal keratoconjunctivitis are distinctive of cell and Hsp type and are modified by inflammatory stimuli [PDF]
, 2016 Background Vernal keratoconjunctivitis (VKC) is a severe ocular allergy with pathogenic mechanism poorly understood and no efficacious treatment. The aims of the study were to determine quantities and distribution of Hsp chaperones in the conjunctiva of ...
Asea +26 more
core +1 more source