Results 71 to 80 of about 6,382,032 (298)

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Zebrafish tumor xenograft models for drug-screening: a systematic review of methods for treatment assessment

Journal of Translational Medicine
Background Zebrafish xenotransplantation models are increasingly employed as drug-screening platforms in precision oncology, offering the advantages of high replicate numbers and rapid data acquisition. Multiple strategies have been developed to evaluate
Oneda Cani, Letizia Zannotti, Alessandro De Vita, Chiara Liverani, Silvia Vanni, Giacomo Miserocchi   +5 more
doaj   +1 more source

Infection Control Practices for Vascular Access Management in Hemodialysis: Results From a Nationwide Survey of Japanese National University Hospitals

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Bloodstream infections due to repeated vascular access (VA) puncture and circuit connections remain major concerns in hemodialysis. Therefore, we examined current practices for glove, disinfectant, and personal protective equipment (PPE) use according to VA type in national university hospitals in Japan.
Aiko Yamada, Makoto Harada, Tadahiko Kikugawa, Takeshi Nakata, Koji Hashimoto, Tsuneo Konta, Yuji Kamijo   +6 more
wiley   +1 more source

First real-world evidence from the Emilia-Romagna region suggests tamoxifen protects breast cancer patients from COVID-19

Scientific Reports
COVID-19 severity is uneven between genders. A role for sex hormones is possible and has been postulated. Considering this idea, we hypothesized hormonal therapies might influence the severity of COVID-19 in breast cancer (BC) patients.
Sara Bravaccini, Fabio Nicolini, William Balzi, Irene Azzali, Luigi Pasini, Lucia Mazzotti, Anna Gaimari, Anna De Lucia, Matteo Zurlo, Roberta Maltoni, Francesca Pirini, Michela Cortesi, Michele Zanoni, Maria Maddalena Tumedei, Oriana Nanni, Claudio Cerchione, Vittorio Sambri, Patricia Borges de Souza, Giovanni Martinelli, Massimiliano Mazza   +19 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Performance Analysis of BLE-5.1 Angle of Arrival Estimation Using Embedded Radiation Patterns on a 3 × 3 Uniform Rectangular Array

IEEE Access
The introduction of new Direction finding (DF) features in Bluetooth Low Energy (BLE) 5.1, has brought about new hardware design requirements for locators.
Ottavio Crisafulli, Nicolo Ivan Piazzese, Santi Concetto Pavone, Giuseppe Giammello, Giovanni Galvagna, Salvatore Pitrulli, Andrea Francesco Morabito, Loreto Di Donato, Michele Sardo, Gino Sorbello   +9 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source