Results 81 to 90 of about 6,382,032 (298)

Multi-Systemic Biological Risk and Cancer Mortality: The NHANES III Study. [PDF]

, 2020
Multi-systemic biological risk (MSBR), a proxy for allostatic load, is a composite index of biomarkers representing dysregulation due to responses to chronic stress. This study examined the association of an MSBR index with cancer mortality.
Acheampong, Teofilia, Jiang, Luohua, Odegaard, Andrew O, Ziogas, Argyrios   +3 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

High malaria parasitemia in an Italian man and severe delayed hemolytic anemia

Clinical Case Reports
Key Clinical Message Parenteral artesunate has become the choice treatment of cases of high parasitemia malaria. We report the case of an Italian man with a high malaria parasitemia who promptly improved with intravenous artenusate, but who developed a ...
Massimiliano Lanzafame, Giovanni Mori, Emanuela Lattuada, Claudio Scarparo   +3 more
doaj   +1 more source

Classical capacity per unit cost for quantum channels

, 2017
In most communication scenarios, sending a symbol encoded in a quantum state requires spending resources such as energy, which can be quantified by a cost of communication.
Jarzyna, Marcin
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PB1985: CHEMO OR CHEMO-FREE REGIMENS IN HEAVILY PRETREATED MULTIPLE MYELOMA? ROLE OF BENDAMUSTINE-BORTEZOMIB-DEXAMETHASONE (BVD) IN NOVEL AGENTS’ ERA

HemaSphere, 2022
C. Cerchione, D. Nappi, A. E. Pareto, S. Ronconi, D. Cangini, M. Ceccolini, G. Musuraca, L. Catalano, G. Martinelli   +8 more
doaj   +1 more source

High-speed digital plotter [PDF]

, 1971
Modified typewriter mechanism with standard logic components provides digital plot of output of multichannel analyzer. Unit plots irregular curves at approximately 14 channels per second, and smooth curves at over 25 channels per second, and is not ...
Gray, J., Jr.
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Breast Cancer Leptomeningeal Metastases on Spinal Epidural Lipomatosis

Diagnostics
We present a case of breast cancer metastases superimposed on epidural lipomatosis and although none of these findings are considered rare, their coexistence leads to unique image findings, and as far as we know there are no other cases like this in ...
Alice Rossi, Giada Sancini, Elena Amadori, Patrizia Cenni, Michela Palleschi, Andrea Prochowski Iamurri   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source