Results 61 to 70 of about 126,075 (293)
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
The effects of cervical muscle fatigue on balance - A study with elite amateur rugby league players [PDF]
, 2014 Neck muscle fatigue has been shown to alter an individual’s balance in a similar way to that reported in subjects suffering from neck pain or subjects that have suffered a neck injury.
Fagan, Michael J., Gosselin, Guy
core
High intensity intermittent running and field hockey skill performance in the heat [PDF]
, 2005 Nine well-trained, unacclimatized female hockey players performed the Loughborough Intermittent Shuttle Test (LIST) interspersed with three field hockey skill tests in hot (30°C, 38% relative humidity) and moderate (19°C, 51% relative humidity ...
Nevill, ME, Sunderland, C
core +1 more source
Molecular Oncology, EarlyView.Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan +4 more
wiley +1 more source
In-season internal and external training load quantification of an elite European soccer team [PDF]
, 2019 Elite soccer teams that participate in European competitions need to have players in the best physical and psychological status possible to play matches.
Brito, João +6 more
core +2 more sources
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
An investigative study into the influence of a commercially available carbohydrate-protein-electrolyte beverage on short term repeated exercise performance [PDF]
, 2012 Background: The purpose of this study was to undertake an independent investigation into the effects of ingesting a carbohydrate-protein-electrolyte (CPE) beverage on repeated submaximal and time-trial cycling performance. Methods: Sixteen recreationally
Kass, Lindsy +3 more
core +4 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Pain Response after Maximal Aerobic Exercise in Adolescents across Weight Status [PDF]
, 2015 Introduction Pain reports are greater with increasing weight status, and exercise can reduce pain perception. It is unknown, however, whether exercise can relieve pain in adolescents of varying weight status.
Bement, Marie K. Hoeger +3 more
core +2 more sources