Results 131 to 140 of about 2,699,721 (304)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

On the relation between income inequality and happiness: Do fairness perceptions matter? [PDF]

In this paper, we revisit the association between happiness and inequality. We argue that the perceived fairness of the income generation process affects this association.
Bjornskov, Christian, Dreher, Axel, Fischer, Justina AV, Schnellenbach, Jan   +3 more
core   +1 more source

Perceveid Social Support in middle school students [PDF]

, 2016
Research on school climate has among its purposes to contribute to improving the quality of education, one of the main challenges of the Mexican educational system, particularly at the level of basic education.
Comesaña, Ana, Peña, José Armando, Ramirez, Laura Minerva, Rodriguez, María Concepción, Vivas, Jorge Ricardo   +4 more
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Relationship between Perceived Social Support in First Pregnancy with Birth Satisfaction in Primigravid Women Referred to Shahid Akbar Abadi Hospital

Preventive Care in Nursing and Midwifery Journal, 2014
Background and Objectives: Recent studies have shown that social and environmental factors as well as social communication play crucial role in pregnancy outcomes.
homa sadeghi aval shahr, sayeh sadat moosavi sahebalzamani, freshteh jahdi, leila neisani samani, hamid haghani   +4 more
doaj  

Perceived Social Support/Conflict [PDF]

, 2020
openaire   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Perceived Social Support Among People with Lived Experience of Serious Mental Illness in Remission and Their Disability: A Cross-Sectional Study

Kerala Journal of Psychiatry
Background: Disability associated with mental illness is a major contributor to the global burden of disease. There are only limited studies assessing perceived social support and disability among patients who are in remission.
Deena Anna Jacob, Sheena Varughese, Joice Geo, Roy Abraham Kallivayalil   +3 more
doaj   +1 more source

Social entrepreneurship: How intentions to create a social enterprise get formed. [PDF]

Social entrepreneurship has raised increasing interest among scholars, yet we still know relatively little about the particular dynamics and processes involved.
Mair, Johanna, Noboa, Ernesto
core