Results 51 to 60 of about 155,523 (221)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Efficient estimation method of population mean with non-response and observational error under ORRT models

Research in Statistics
This study addresses the difficulties faced by surveyors in collecting responses to sensitive questions, which lead to non-sampling errors such as non-response and observational error.
Sunil Kumar, Chanda Rani, Housila P. Singh, J. P. S. Joorel   +3 more
doaj   +1 more source

Increased Statistical Efficiency in a Lognormal Mean Model

Journal of Probability and Statistics, 2014
Within the context of clinical and other scientific research, a substantial need exists for an accurate determination of the point estimate in a lognormal mean model, given that highly skewed data are often present.
Grant H. Skrepnek, Ashok Sahai
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Evaluation of Origanum vulgare L. essential oil as a source of toxicant and an inhibitor of physiological parameters in diamondback moth, Plutella xylustella L. (Lepidoptera: Pyralidae)

Journal of the Saudi Society of Agricultural Sciences, 2017
The effect of essential oil of Origanum vulgare L. a medicinal plant was studied on toxicity, physiology and biochemical characteristics of diamondback moth Plutella xylustella L. in controlled condition.
Mahsa Nasr, Jalal Jalali Sendi, Saeid Moharramipour, Arash Zibaee   +3 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Highly Efficient Terahertz Waveguide Using Two-Dimensional Tellurium Photonic Crystals with Complete Photonic Bandgaps

Crystals
A novel, highly efficient terahertz fully polarized transmission line is designed by two-dimensional tellurium photonic crystals consisting of square lattice rod arrays with a complete photonic bandgap.
Yong Wang, Luyao Feng, Hongwei Huang, Zhifeng Zeng, Yuhan Liu, Xiaotong Liu, Xingquan Li, Kaiming Yang, Zhijian Zheng, Biaogang Xu, Wenlong He, Shaobin Zhan, Wenli Wang   +12 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A new novel index for evaluating model performance

Journal of Natural Resources and Development, 2014
A vast array of scientific literature is concerned with simulation models. The aim of models is to predict the unknown situation as close to as real one. To do this, models are validated and examined for their performance under known condition.
M. H. Ali, I. Abustan
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source