FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Artificial Intelligence in Periodontology: From Automated Diagnosis to Prediction and Clinical Decision Support-A Narrative Review. [PDF]
Dent J (Basel)Herz MM, Bartha V.
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Heterogeneous Information and Appraisal Smoothing [PDF]
This study examines the heterogeneous appraiser behavior and its implication on the traditional appraisal smoothing theory. We show that the partial adjustment model is consistent with the traditional appraisal smoothing argument only when all the ...
Yingchun Liu, Zhenguo Lin, Ping Cheng
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Musical Episodic Modulation of Human Functioning: Anticipation Mechanisms, Personal Sense, and Emotional Recall. [PDF]
Integr Psychol Behav SciVieira RD.
europepmc +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
An assessment of Kabarak University performance appraisal systems
, 2010 Effectiveness of performance appraisal systems in private Universities in KenyaPerformance appraisal system is important to any organizational work performance; it determines the organization’s success or failure.
Magutu, Peterson O +2 more
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Toward a decent learning theory: a structural-psychological framework for understanding students' appraisals of learning. [PDF]
Front PsycholXue B, Luo H.
europepmc +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Computer Aided Design Appraisal - a Modest Experiment
, 2004 The paper starts with a re-iteration of the concept of appraisal of digital prototypes during the early phases of the architectural design activity and with a summary of research and development from the early seventies to the current time, the use of ...
J. Petric, T.W. Maver
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