Task Force 9: Drugs and performance-enhancing substances
Journal of the American College of Cardiology, 2005 Athletes commonly use drugs and dietary supplements because they hope to improve athletic performance. These performance-enhancing substances include ergogenic and thermogenic supplements, stimulants, anabolic steroids, peptide hormones, and others.
Estes, N.A. Mark +3 more
openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
THE FREQUENCY OF MISUSE IN EGYPTIAN GYMNASIUMS FOR PERFORMANCE-ENHANCING PURPOSES: A TOXICOLOGICAL AND FORENSIC PERSPECTIVE CROSS-SECTIONAL STUDY [PDF]
The Egyptian Journal of Forensic Sciences and Applied ToxicologyBackground: The misuse of over-the-counter (OTC) and prescription medications for performance-enhancing purposes is a growing concern in gym settings globally, including Egypt. These substances, including anabolic-androgenic steroids (AAS) and stimulants,
Mokhtar Fathy Abdel-satar +2 more
doaj +1 more source
Comment on "Recreational Athletes' Use of Performance‑Enhancing Substances: Results from the First European Randomized Response Technique Survey". [PDF]
Sports Med Open, 2023 Petrou M, Lazuras L.
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
NPS, PEDs and other emerging drugs on the Clearnet and the Darkweb: Use in sport
Emerging Trends in Drugs, Addictions, and HealthThe aim of the project was to identify new performance enhancing drugs (PEDs) including novel psychoactive substances (NPS) both in the Darkweb as well as in the Clearnet that could be offered to athletes to improve their performance.Searches on the ...
Irene Mazzoni, Olivier Rabin
doaj +1 more source
Authors' Reply to Petrou & Lazuras: 'Recreational Athletes' Use of Performance-Enhancing Substances: Results from the First European Randomized Response Technique Survey'. [PDF]
Sports Med Open, 2023 Christiansen AV +3 more
europepmc +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source