Results 111 to 120 of about 1,215,000 (384)

Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research. [PDF]

, 2017
Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size.
Akyol, Onat, Applegate, Richard, Araujo, Camila, Ho, Wing Mann, Huang, Lei, Reis, Cesar, Zhang, John H   +6 more
core   +3 more sources

A longitudinal characterization of perfusion in the aging brain and associations with cognition and neural structure

Human Brain Mapping, 2019
Cerebral perfusion declines across the lifespan and is altered in the early stages of several age‐related neuropathologies. Little is known, however, about the longitudinal evolution of perfusion in healthy older adults, particularly when perfusion is ...
A. Staffaroni, Y. Cobigo, F. Elahi, K. Casaletto, Samantha M. Walters, Amy Wolf, C. Lindbergh, H. Rosen, J. Kramer   +8 more
semanticscholar   +1 more source

Near‐Infrared Organic Photovoltaic Electrodes for Subretinal Neurostimulation

Advanced Functional Materials, EarlyView.
Organic photovoltaic electrodes based on the D18:Y6 blend enable precise and light‐controlled activation of retinal ganglion cells in a degenerating retina. NIR Light‐driven activation of retinal ganglion cells, tunable stimulation parameters, and biocompatibility with human retinal organoids highlight their potential for next‐generation prosthetics ...
Andrea Corna, Katarina Gugujonovic, Manuela Schiek, Alessandro Bellapianta, Paul Werginz, Amelie Ziller, Markus Clark Scharber, Ahmad Salti, Matthias Bolz, Mihai Irimia‐Vladu, Günther Zeck   +10 more
wiley   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Simulated cardiopulmonary bypass: a high fidelity model for developing and accessing clinical perfusion skills

Advances in Simulation
Background Traditionally, novice perfusionists learn and practice clinical skills, during live surgical procedures. The profession’s accrediting body is directing schools to implement simulated cardiopulmonary bypass (CPB) into the curriculum ...
Bruce E. Searles, Jeffrey B. Riley, Edward M. Darling, Jason R. Wiles   +3 more
doaj   +1 more source

Capillaroscopy in 2016 : new perspectives in systemic sclerosis [PDF]

, 2016
Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by early impairment of the microvascular system. Nailfold microangiopathy and decreased peripheral blood perfusion are typical clinical aspects of SSc.
Cutolo, M, Llado, A, Paolino, S, Pizzorni, C, Ruaro, B, Smith, Vanessa, Sulli, A   +6 more
core   +1 more source

The endothelial glycocalyx prefers albumin for evoking shear stress-induced, nitric oxide-mediated coronary dilatation [PDF]

, 2007
Background: Shear stress induces coronary dilatation via production of nitric oxide ( NO). This should involve the endothelial glycocalyx ( EG). A greater effect was expected of albumin versus hydroxyethyl starch ( HES) perfusion, because albumin seals ...
Bernhard F. Becker, Chang YS, Desjardins C, Dirk Bruegger, Gonzalez-Castillo C, Huxley VH, Joern O. Paul, Kuchan MJ, Leipert B, Markus Rehm, Matthias Jacob, Michael Loetsch, Mochizuki S, Mulivor AW, Peter Conzen, Platts SH, Pohl U, Pries AR, Risau W, Rubanyi GM, Siegel G, Ulrich Welsch, van Haaren P, Vink H, Vink H, Vink H   +25 more
core   +1 more source

Combined Hypothermic and Normothermic Machine Perfusion Improves Functional Recovery of Extended Criteria Donor Livers

Liver transplantation, 2018
Hypothermic oxygenated perfusion (HOPE) and normothermic perfusion are seen as distinct techniques of ex situ machine perfusion of the liver. We aimed to demonstrate the feasibility of combining both techniques and whether it would improve functional ...
Y. Boteon, R. Laing, A. Schlegel, L. Wallace, Amanda Smith, J. Attard, R. Bhogal, D. Neil, S. Hübscher, M. Perera, D. Mirza, S. Afford, H. Mergental   +12 more
semanticscholar   +1 more source

Structural and perfusion magnetic resonance imaging of congenital lung malformations [PDF]

, 2020
Christian J. Kellenberger, Christina Amaxopoulou, Ueli Moehrlen, Peter K. Bode, Andreas Jung, Julia Geiger   +5 more
openalex   +1 more source

Interconnected Porous Hydrogels with Tunable Anisotropy Through Aqueous Emulsion Bioprinting

Advanced Functional Materials, EarlyView.
A 3D bioprintable microporous bioink is developed using an aqueous two‐phase system (ATPS) composed of extracellular matrix (ECM) mimetic biopolymers. The ATPS bioink enables the fabrication of interconnected porous architectures with up to 70% porosity, supporting long‐term cell viability and 3D cell alignment, enabling a simultaneous generation of ...
Hugo Edgar‐Vilar, Francisca P. Correia, Inês M. Freitas, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source