Results 121 to 130 of about 787,249 (370)

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden   +5 more
wiley   +1 more source

Immune‐Infiltrated Cancer Spheroid Model with Vascular Recirculation Reveals Temporally Dependent and Tissue‐Specific Macrophage Recruitment

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.
The migration and infiltration of circulating monocytes into cancer spheroids are shown using a pumpless recirculating platform. This method allows for the continuous circulation of immune cells, which is essential for observing the long‐term dynamic behavior of immune cells within cancer environments.
Feng Zhang   +6 more
wiley   +1 more source

Kidney Fibrosis In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.
This review discusses kidney diseases with a focus on kidney fibrosis and the models currently used. It highlights the limitations of animal and 2D in vitro models in replicating human kidney anatomy and physiology. Consequently, there is a significant need for humanized 3D in vitro models, such as 3D cell aggregates, membranes and hydrogels, on‐chip ...
Gabriele Addario   +2 more
wiley   +1 more source

Altered Cerebral Blood Flow is Linked to Disease Duration in Patients with Generalized tonic‒clonic Seizures

open access: yesNeuropsychiatric Disease and Treatment, 2022
Ting Li1,2 *, Shaowei Niu3 *, Xiang Qiu4 *, Zhaohua Zhai,2 Lin Yang,2 Li Chen,2 Xiao Ming Zhang1,2 1The First Affiliated Hospital, Jinan University, Guangzhou, People’s Republic of China; 2Medical Imaging Key Laboratory of Sichuan Province ...
Li T   +6 more
doaj  

CUSUM Filter for Brain Segmentation on DSC Perfusion MR Head Scans with Abnormal Brain Anatomy [PDF]

open access: yesProceedings of the 2019 3rd International Conference on Frontiers of Image Processing (ICFIP 2019). - Florence, Italy, March 16-18, 2019. - P008, 2019
This paper presents a new approach for relatively accurate brain region of interest (ROI) detection from dynamic susceptibility contrast (DSC) perfusion magnetic resonance (MR) images of a human head with abnormal brain anatomy. Such images produce problems for automatic brain segmentation algorithms, and as a result, poor perfusion ROI detection ...
arxiv  

Static and dynamic assessment of myocardial perfusion by computed tomography.

open access: yesEuropean Heart Journal-Cardiovascular Imaging, 2016
Recent developments in computed tomography (CT) technology have fulfilled the prerequisites for the clinical application of myocardial CT perfusion (CTP) imaging.
I. Danad   +3 more
semanticscholar   +1 more source

Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the Endothelium

open access: yesAdvanced Healthcare Materials, EarlyView.
Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche   +16 more
wiley   +1 more source

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