Results 121 to 130 of about 825,159 (286)

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

The relationship between parameters measured using intravoxel incoherent motion and dynamic contrast-enhanced MRI in patients with breast cancer undergoing neoadjuvant chemotherapy: a longitudinal cohort study

Frontiers in Oncology
PurposeThe primary aim of this study was to explore whether intravoxel incoherent motion (IVIM) can offer a contrast-agent-free alternative to dynamic contrast-enhanced (DCE)-MRI for measuring breast tumor perfusion.
Zyad M. Almutlaq, Zyad M. Almutlaq, Sarah E. Bacon, Daniel J. Wilson, Nisha Sharma, Tatendashe Dondo, David L. Buckley   +6 more
doaj   +1 more source

Paracrine Factor Local Gradient‐Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion‐Induced Proliferation

Advanced Healthcare Materials, EarlyView.
A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang, Tadahiro Yamashita, Ryo Sudo   +2 more
wiley   +1 more source

Estimation of reference curves for brain atrophy and analysis of robustness to machine effects

Scientific Reports
Neurodegenerative diseases like Alzheimer’s are difficult to diagnose due to brain complexity and imaging variability. However, volumetric analysis tools, using reference curves, help detect abnormal brain atrophy and support diagnosis and monitoring ...
Elodie Piot, Félix Renard, Arnaud Attyé, Alexandre Krainik, for the Alzheimer’s Disease Neuroimaging Initiative, For the Frontotemporal Lobar Degeneration Neuroimaging Initiative   +5 more
doaj   +1 more source

3D bioprinting for the production of a perfusable vascularized model of a cancer niche

Frontiers in Bioengineering and Biotechnology
The ever-growing need for improved in vitro models of human tissues to study both healthy and diseased states is advancing the use of techniques such as 3D Bioprinting.
Federico Maggiotto, Federico Maggiotto, Lorenzo Bova, Lorenzo Bova, Lorenzo Bova, Sara Micheli, Sara Micheli, Camilla Pozzer, Pina Fusco, Pina Fusco, Paolo Sgarbossa, Fabrizio Billi, Elisa Cimetta, Elisa Cimetta   +13 more
doaj   +1 more source

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Dynamic Modulation of the Microenvironment Promotes Functional Maturation of Engineered Tissues

Advanced Healthcare Materials, EarlyView.
Engineered tissues lack the dynamic microenvironment of native tissues. A biocompatible, diffusible small molecule to dynamically modulate tissue microenvironments during maturation is used. Timing‐dependent modulation yields distinct outcomes, producing thicker, more native‐like blood vessels, stronger and more mature cardiac tissues, and optimized ...
Eric Silberman, Hadas Oved, Itay Gil, Amgad Marzook, Ester Sapir Baruch, Yahel Shechter, Assaf Shapira, Tal Dvir   +7 more
wiley   +1 more source

Complement activation by the artificial surface of cardiopulmonary bypass is a persistent clinical problem

Scientific Reports
Activation of the alternative complement pathway by artificial extracorporeal surfaces is relevant to several clinical applications such as cardiac surgery with cardiopulmonary bypass (CPB), thoracic organ transplantation and hemodialysis.
Joel David Bierer, Roger Stanzel, Mark Henderson, Tony El-Rabahi, John Sapp, Pantelis Andreou, Jean S. Marshall, David Conrad, David Horne   +8 more
doaj   +1 more source

Changes in perfusion and permeability in glioblastoma model induced by the anti-angiogenic agents cediranib and thalidomide

Acta Oncologica
Background and purpose: The poor delivery of drugs to infiltrating tumor cells contributes to therapeutic failure in glioblastoma. During the early phase of an anti-angiogenic treatment, a remodeling of the tumor vasculature could occur, leading to a ...
Jérôme Conq, Nicolas Joudiou, Véronique Préat, Bernard Gallez   +3 more
doaj   +1 more source

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source