Results 61 to 70 of about 10,316 (244)

Intraluminal pressure elevates intracellular calcium and contracts CNS pericytes: Role of voltage-dependent calcium channels

, 2023
Arteriolar smooth muscle cells (SMCs) and capillary pericytes dynamically regulate blood flow in the central nervous system in the face of fluctuating perfusion pressures.
O'Brien, Rochelle Irene C, Thomas J. Heppner, Albert L. Gonzales, Heppner, Thomas J, Gonzales, Albert L, Sancho, Maria, Hill-Eubanks, David, Rochelle Irene C. O’Brien, Nicholas R. Klug, Nelson, Mark T, Heppner, Thomas J., Klug, Nicholas R, Sancho González, María, O’Brien, Rochelle Irene C., Nelson, Mark T., David Hill-Eubanks, Klug, Nicholas R., Maria Sancho, Mark T. Nelson, Gonzales, Albert L.   +19 more
core   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Inhibition of Lysyl Oxidases Impairs Migration and Angiogenic Properties of Tumor-Associated Pericytes

Stem Cells International, 2017
Pericytes are important cellular components of the tumor microenviroment with established roles in angiogenesis and metastasis. These two cancer hallmarks are modulated by enzymes of the LOX family, but thus far, information about LOX relevance in tumor ...
Aline Lopes Ribeiro, Carolini Kaid, Patrícia B. G. Silva, Beatriz A. Cortez, Oswaldo Keith Okamoto   +4 more
doaj   +1 more source

Extrusion Bioprinting for Wound Healing: Innovations in Functionalized Bioinks and Bioprinting Technology

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le, Anh Tuan Trong Tran, Ammara Waheed, Tran Thanh Tung, Dusan Losic   +4 more
wiley   +1 more source

Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress

Scientific Reports, 2022
Parkinson’s disease (PD) is characterised by the progressive loss of midbrain dopaminergic neurons and the presence of aggregated α-synuclein (α-syn). Pericytes and microglia, two non-neuronal cells contain α-syn in the human brain, however, their role ...
Taylor J. Stevenson, Rebecca H. Johnson, Jimmy Savistchenko, Justin Rustenhoven, Zoe Woolf, Leon C. D. Smyth, Helen C. Murray, Richard L. M. Faull, Jason Correia, Patrick Schweder, Peter Heppner, Clinton Turner, Ronald Melki, Birger V. Dieriks, Maurice A. Curtis, Michael Dragunow   +15 more
doaj   +1 more source

A U‐shaped Microfluidic Platform for Culturing Vascularized Colorectal Cancer Spheroids Reveals Tumor–Endothelial Crosstalk and Invasion‐Associated Remodeling

Advanced Materials Technologies, EarlyView.
A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti, M. Ballerini, A. Mantegazza, P. Occhetta, M. Rasponi   +4 more
wiley   +1 more source

Specialized pericyte subtypes in the pulmonary capillaries

The EMBO Journal
Pericytes are essential for capillary stability and homeostasis, with impaired pericyte function linked to diseases like pulmonary arterial hypertension.
Timothy Klouda, Yunhye Kim, Seung-Han Baek, Mantu Bhaumik, Yan Li, Yu Liu, Joseph C Wu, Benjamin A Raby, Vinicio de Jesus Perez, Ke Yuan   +9 more
doaj   +1 more source

Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D

Fluids and Barriers of the CNS, 2019
Background Pericytes of the blood–brain barrier (BBB) are embedded within basement membrane between brain microvascular endothelial cells (BMECs) and astrocyte end-feet.
John J. Jamieson, Raleigh M. Linville, Yuan Yuan Ding, Sharon Gerecht, Peter C. Searson   +4 more
doaj   +1 more source

Pericytes in tissue fibrosis

American Journal of Physiology-Cell Physiology
Pericytes are mural cells, embedded within the microvascular basement membrane and primarily involved in preservation of vessel integrity and regulation of vascular permeability and blood flow. Their study poses major challenges due to the absence of specific and reliable markers for their identification. Emerging evidence suggests that, in addition to
Izabela Tuleta, Nikolaos G. Frangogiannis   +1 more
openaire   +3 more sources

The role played by perivascular cells in kidney interstitial injury

, 2014
Fibrosis of the kidney is a disease affecting millions worldwide and is a harbinger of progressive loss of organ function resulting in organ failure. Recent findings suggest that understanding mechanisms of development and progression of fibrosis will ...
林水龍, Rojas, Andres;Chang, Fan-Chi;Lin, Shuei-Liong;Duffield, Jeremy S.   +1 more
core   +1 more source