Results 1 to 10 of about 30,427 (250)

Pericyte-to-Endothelial Cell Communication via Tunneling Nanotubes Is Disrupted by a Diol of Docosahexaenoic Acid

Cells
The pericyte coverage of microvessels is altered in metabolic diseases, but the mechanisms regulating pericyte–endothelial cell communication remain unclear.
Ilka Wittig, Stephan Klatt, Ingrid Fleming   +2 more
exaly   +4 more sources

Mechanism of retinal pericyte migration through Angiopoietin/Tie-2 signaling pathway on diabetic rats [PDF]

International Journal of Ophthalmology, 2018
AIM: To investigate the mechanism of pericyte migration through Angiopoietin-2 (Ang-2)/Tie-2 signaling pathway. METHODS: We divided the rats into 5 groups. Each diabetic rat model groups injected with Tie-2 inhibitor, ERK1/2 inhibitor, Akt/PKB inhibitor,
Nadia Artha Dewi, Aulanni'am Aulanni’am, Hidayat Sujuti, Muhammad Aris Widodo, Djoko Wahono Soeatmadji   +4 more
doaj   +2 more sources

Understanding the Heterogeneity of Human Pericyte Subsets in Blood–Brain Barrier Homeostasis and Neurological Diseases

Cells, 2021
Pericytes are increasingly recognized as being important in the control of blood–brain barrier permeability and vascular flow. Research on this important cell type has been hindered by widespread confusion regarding the phenotypic identity and ...
Woong-Ki Kim, Diana G Bohannon
exaly   +3 more sources

Transcriptional analyses identify pericyte-centered signaling programs altered by sex and brain region in Alzheimer’s Disease [PDF]

Communications Biology
Pericytes are critical components of the neurovascular unit (NVU), regulating endothelial cell stability, blood-brain barrier (BBB) integrity, and neuroimmune signaling.
Kareem El-Ghazawi, Yonathan T. Aberra, Yashasvisai Veeramasu, Wisam A. Fares, Brant E. Isakson, Harald Sontheimer, Ukpong B. Eyo, Shayn M. Peirce   +7 more
doaj   +2 more sources

Engineered Pericyte‐Targeted Extracellular Vesicles Protect Against Hypoperfusion‐Induced Cognitive Impairment and Vascular Demyelination [PDF]

Journal of Extracellular Vesicles
Pericyte dysfunction is an early hallmark of vascular cognitive impairment (VCI), yet targeted therapies remain limited. Here, we develop a bio‐orthogonal approach to engineer extracellular vesicles (EVs) functionalized with cyclic NGR (cNGR) peptides ...
Weiwei Shen, Weishi Liu, Min Guo, Tongyao You, Yingzhe Wang, Tiansiyu Wen, Suzhen Liang, Xiaodi Xie, Yanfeng Jiang, Qiang Dong, Jin‐Tai Yu, Mei Cui   +11 more
doaj   +2 more sources

In vivo Single Cell Optical Ablation of Brain Pericytes

Frontiers in Neuroscience, 2022
Pericytes have myriad functions in cerebrovascular regulation but remain understudied in the living brain. To dissect pericyte functions in vivo, prior studies have used genetic approaches to induce global pericyte loss in the rodent brain. However, this
Cara D. Nielson, Cara D. Nielson, Andrée-Anne Berthiaume, Andrée-Anne Berthiaume, Stephanie K. Bonney, Andy Y. Shih, Andy Y. Shih, Andy Y. Shih   +7 more
doaj   +1 more source

Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure

Nature Communications, 2022
Using in vivo two-photon imaging, Berthiaume et al. demonstrate how pericyte loss during aging could contribute to deterioration of cerebral blood flow. They also show how pericyte remodeling reduces the deleterious effects of pericyte loss.
Andrée-Anne Berthiaume, Franca Schmid, Stefan Stamenkovic, Vanessa Coelho-Santos, Cara D. Nielson, Bruno Weber, Mark W. Majesky, Andy Y. Shih   +7 more
doaj   +1 more source

Ulmus davidiana 60% edible ethanolic extract for prevention of pericyte apoptosis in diabetic retinopathy

Frontiers in Endocrinology, 2023
Diabetic retinopathy (DR) is a disease that causes visual deficiency owing to vascular leakage or abnormal angiogenesis. Pericyte apoptosis is considered one of the main causes of vascular leakage in diabetic retina, but there are few known therapeutic ...
Iljin Kim, Jieun Seo, Dong Hyun Lee, Yo-Han Kim, Jun-Hyung Kim, Myung-Bok Wie, Jun-Kyu Byun, Jang-Hyuk Yun   +7 more
doaj   +1 more source

Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature

Neurobiology of Disease, 2018
Background: Cerebrovascular dysfunction and inflammation occur in epilepsy. Here we asked whether pericytes, a pivotal cellular component of brain capillaries, undergo pathological modifications during experimental epileptogenesis and in human epilepsy ...
Wendy Klement, Rita Garbelli, Emma Zub, Laura Rossini, Laura Tassi, Benoit Girard, Marine Blaquiere, Federica Bertaso, Julie Perroy, Frederic de Bock, Nicola Marchi   +10 more
doaj   +1 more source

Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth

Nature Communications, 2020
The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour growth, but how pericyte FAK regulates tumour angiogenesis is unknown.
Tanguy Lechertier, Louise E. Reynolds, Hyojin Kim, Ana Rita Pedrosa, Jesús Gómez-Escudero, José M. Muñoz-Félix, Silvia Batista, Matthew Dukinfield, Fevzi Demircioglu, Ping Pui Wong, Kylie P. Matchett, Neil C. Henderson, Gabriela D’Amico, Maddy Parsons, Catherine Harwood, Pascal Meier, Kairbaan M. Hodivala-Dilke   +16 more
doaj   +1 more source