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Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications [PDF]

Frontiers in Cell and Developmental Biology, 2020
Pericytes are mural vascular cells found predominantly on the abluminal wall of capillaries, where they contribute to the maintenance of capillary structural integrity and vascular permeability. Generally quiescent cells in the adult, pericyte activation
Emmanuel Nwadozi, Martina Rudnicki, Tara L. Haas   +2 more
doaj   +3 more sources

Differential pericyte pathology in the human retina and brain in diabetes mellitus and Alzheimer’s disease [PDF]

Frontiers in Neuroscience
IntroductionIn diabetic retinopathy, pericyte dysfunction, pericyte loss, and inner blood–retinal barrier (iBRB) dysfunction contribute to neurovascular unit (NVU) impairment.
Noëlle Bakker-van Bugnum, Noëlle Bakker-van Bugnum, Noëlle Bakker-van Bugnum, Aïcha A. Croes, Eva Prevaes, Cornelis J. F. van Noorden, Reinier O. Schlingemann, Reinier O. Schlingemann, Reinier O. Schlingemann, Ingeborg Klaassen, Ingeborg Klaassen, Ingeborg Klaassen   +11 more
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Diabetes associated pericyte metabolic signatures and pathogenesis of diabetic retinopathy [PDF]

Frontiers in Endocrinology
Pericytes are metabolically active perivascular supporting cells. They are essential for establishing and maintaining the inner blood retinal barrier and retinal neurovascular homeostasis.
Casandra Carrillo, Teri L. Belecky-Adams, Nader Sheibani   +2 more
doaj   +2 more sources

MicroRNA210 regulated brain pericyte dysfunction exacerbates hypoxic-ischemic brain injury in neonatal mice [PDF]

Fluids and Barriers of the CNS
Background While the role of pericytes in blood-brain barrier (BBB) disruption and neuroinflammation is well-established in adult neurological disorders, their contribution to neonatal brain injury is largely unexplored. Here, we investigated the role of
Shirley Hu, Yanelly Lopez-Robles, Elena Liu, Yangtao Lin, Wanqiu Chen, Chaitra Manjunath, Zhen Zhao, Lubo Zhang, Qingyi Ma   +8 more
doaj   +2 more sources

FOXF2 regulates pericyte–endothelial signaling required for vascular homeostasis after neonatal hyperoxic lung injury [PDF]

Nature Communications
Pulmonary vascular development is essential for alveolarization, and disruption of this process contributes to pathogenesis of bronchopulmonary dysplasia (BPD).
Fei Sun, Yuchen Zhao, Jonathan Do, Peng Cheng, Enhong Li, Yanru Liu, Shawyon P. Shirazi, Jennifer M. S. Sucre, Tanya V. Kalin, Hua He, Vladimir V. Kalinichenko   +10 more
doaj   +2 more sources

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity [PDF]

Advanced Science
Pericytes exhibits distinct morphological features on microvessels during various stages of brain‐blood barrier (BBB) development and neurological disorders. However, the underlying mechanisms by which pericyte morphology influences BBB integrity are not
Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, Yue Dai, Zhao‐You Meng, Chen‐Hao Zhao, Bao‐Liang Sun, Qi Xie, Fang‐Fei Li, Qing‐Wu Yang   +16 more
doaj   +2 more sources

In vivo Single Cell Optical Ablation of Brain Pericytes

Frontiers in Neuroscience, 2022
Pericytes have myriad functions in cerebrovascular regulation but remain understudied in the living brain. To dissect pericyte functions in vivo, prior studies have used genetic approaches to induce global pericyte loss in the rodent brain. However, this
Cara D. Nielson, Cara D. Nielson, Andrée-Anne Berthiaume, Andrée-Anne Berthiaume, Stephanie K. Bonney, Andy Y. Shih, Andy Y. Shih, Andy Y. Shih   +7 more
doaj   +1 more source

Endothelial Progenitors Exist within the Kidney and Lung Mesenchyme [PDF]

, 2013
The renal endothelium has been debated as arising from resident hemangioblast precursors that transdifferentiate from the nephrogenic mesenchyme (vasculogenesis) and/or from invading vessels (angiogenesis).
Bates, CM, Bushnell, D, Gittes, G, Ho, J, Logar, A, Prochownik, E, Schaefer, C, Sims-Lucas, S   +7 more
core   +11 more sources

Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure

Nature Communications, 2022
Using in vivo two-photon imaging, Berthiaume et al. demonstrate how pericyte loss during aging could contribute to deterioration of cerebral blood flow. They also show how pericyte remodeling reduces the deleterious effects of pericyte loss.
Andrée-Anne Berthiaume, Franca Schmid, Stefan Stamenkovic, Vanessa Coelho-Santos, Cara D. Nielson, Bruno Weber, Mark W. Majesky, Andy Y. Shih   +7 more
doaj   +1 more source

Mechanism of retinal pericyte migration through Angiopoietin/Tie-2 signaling pathway on diabetic rats [PDF]

International Journal of Ophthalmology, 2018
AIM: To investigate the mechanism of pericyte migration through Angiopoietin-2 (Ang-2)/Tie-2 signaling pathway. METHODS: We divided the rats into 5 groups. Each diabetic rat model groups injected with Tie-2 inhibitor, ERK1/2 inhibitor, Akt/PKB inhibitor,
Nadia Artha Dewi, Aulanni'am Aulanni’am, Hidayat Sujuti, Muhammad Aris Widodo, Djoko Wahono Soeatmadji   +4 more
doaj   +1 more source