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Cells, 2021 Pericytes are increasingly recognized as being important in the control of blood–brain barrier permeability and vascular flow. Research on this important cell type has been hindered by widespread confusion regarding the phenotypic identity and ...
Woong-Ki Kim +2 more
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Differential pericyte pathology in the human retina and brain in diabetes mellitus and Alzheimer’s disease [PDF]
Frontiers in NeuroscienceIntroductionIn diabetic retinopathy, pericyte dysfunction, pericyte loss, and inner blood–retinal barrier (iBRB) dysfunction contribute to neurovascular unit (NVU) impairment.
Noëlle Bakker-van Bugnum +11 more
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Diabetes associated pericyte metabolic signatures and pathogenesis of diabetic retinopathy [PDF]
Frontiers in EndocrinologyPericytes are metabolically active perivascular supporting cells. They are essential for establishing and maintaining the inner blood retinal barrier and retinal neurovascular homeostasis.
Casandra Carrillo +2 more
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Engineered Pericyte‐Targeted Extracellular Vesicles Protect Against Hypoperfusion‐Induced Cognitive Impairment and Vascular Demyelination [PDF]
Journal of Extracellular VesiclesPericyte dysfunction is an early hallmark of vascular cognitive impairment (VCI), yet targeted therapies remain limited. Here, we develop a bio‐orthogonal approach to engineer extracellular vesicles (EVs) functionalized with cyclic NGR (cNGR) peptides ...
Weiwei Shen +11 more
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MicroRNA210 regulated brain pericyte dysfunction exacerbates hypoxic-ischemic brain injury in neonatal mice [PDF]
Fluids and Barriers of the CNSBackground While the role of pericytes in blood-brain barrier (BBB) disruption and neuroinflammation is well-established in adult neurological disorders, their contribution to neonatal brain injury is largely unexplored. Here, we investigated the role of
Shirley Hu +8 more
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FOXF2 regulates pericyte–endothelial signaling required for vascular homeostasis after neonatal hyperoxic lung injury [PDF]
Nature CommunicationsPulmonary vascular development is essential for alveolarization, and disruption of this process contributes to pathogenesis of bronchopulmonary dysplasia (BPD).
Fei Sun +10 more
doaj +2 more sources
In vivo Single Cell Optical Ablation of Brain Pericytes
Frontiers in Neuroscience, 2022 Pericytes have myriad functions in cerebrovascular regulation but remain understudied in the living brain. To dissect pericyte functions in vivo, prior studies have used genetic approaches to induce global pericyte loss in the rodent brain. However, this
Cara D. Nielson +7 more
doaj +1 more source
Nature Communications, 2022 Using in vivo two-photon imaging, Berthiaume et al. demonstrate how pericyte loss during aging could contribute to deterioration of cerebral blood flow. They also show how pericyte remodeling reduces the deleterious effects of pericyte loss.
Andrée-Anne Berthiaume +7 more
doaj +1 more source
Mechanism of retinal pericyte migration through Angiopoietin/Tie-2 signaling pathway on diabetic rats [PDF]
International Journal of Ophthalmology, 2018 AIM: To investigate the mechanism of pericyte migration through Angiopoietin-2 (Ang-2)/Tie-2 signaling pathway. METHODS: We divided the rats into 5 groups. Each diabetic rat model groups injected with Tie-2 inhibitor, ERK1/2 inhibitor, Akt/PKB inhibitor,
Nadia Artha Dewi +4 more
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Frontiers in Endocrinology, 2023 Diabetic retinopathy (DR) is a disease that causes visual deficiency owing to vascular leakage or abnormal angiogenesis. Pericyte apoptosis is considered one of the main causes of vascular leakage in diabetic retina, but there are few known therapeutic ...
Iljin Kim +7 more
doaj +1 more source