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Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications [PDF]
Frontiers in Cell and Developmental Biology, 2020 Pericytes are mural vascular cells found predominantly on the abluminal wall of capillaries, where they contribute to the maintenance of capillary structural integrity and vascular permeability. Generally quiescent cells in the adult, pericyte activation
Emmanuel Nwadozi +2 more
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Engineered Pericyte‐Targeted Extracellular Vesicles Protect Against Hypoperfusion‐Induced Cognitive Impairment and Vascular Demyelination [PDF]
Journal of Extracellular VesiclesPericyte dysfunction is an early hallmark of vascular cognitive impairment (VCI), yet targeted therapies remain limited. Here, we develop a bio‐orthogonal approach to engineer extracellular vesicles (EVs) functionalized with cyclic NGR (cNGR) peptides ...
Weiwei Shen +11 more
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Diabetes associated pericyte metabolic signatures and pathogenesis of diabetic retinopathy [PDF]
Frontiers in EndocrinologyPericytes are metabolically active perivascular supporting cells. They are essential for establishing and maintaining the inner blood retinal barrier and retinal neurovascular homeostasis.
Casandra Carrillo +2 more
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In vivo Single Cell Optical Ablation of Brain Pericytes
Frontiers in Neuroscience, 2022 Pericytes have myriad functions in cerebrovascular regulation but remain understudied in the living brain. To dissect pericyte functions in vivo, prior studies have used genetic approaches to induce global pericyte loss in the rodent brain. However, this
Cara D. Nielson +7 more
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Nature Communications, 2022 Using in vivo two-photon imaging, Berthiaume et al. demonstrate how pericyte loss during aging could contribute to deterioration of cerebral blood flow. They also show how pericyte remodeling reduces the deleterious effects of pericyte loss.
Andrée-Anne Berthiaume +7 more
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Mechanism of retinal pericyte migration through Angiopoietin/Tie-2 signaling pathway on diabetic rats [PDF]
International Journal of Ophthalmology, 2018 AIM: To investigate the mechanism of pericyte migration through Angiopoietin-2 (Ang-2)/Tie-2 signaling pathway. METHODS: We divided the rats into 5 groups. Each diabetic rat model groups injected with Tie-2 inhibitor, ERK1/2 inhibitor, Akt/PKB inhibitor,
Nadia Artha Dewi +4 more
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Cells, 2021 Pericytes are increasingly recognized as being important in the control of blood–brain barrier permeability and vascular flow. Research on this important cell type has been hindered by widespread confusion regarding the phenotypic identity and ...
Diana G. Bohannon +2 more
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Frontiers in Endocrinology, 2023 Diabetic retinopathy (DR) is a disease that causes visual deficiency owing to vascular leakage or abnormal angiogenesis. Pericyte apoptosis is considered one of the main causes of vascular leakage in diabetic retina, but there are few known therapeutic ...
Iljin Kim +7 more
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Nature Communications, 2020 The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour growth, but how pericyte FAK regulates tumour angiogenesis is unknown.
Tanguy Lechertier +16 more
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Neurobiology of Disease, 2018 Background: Cerebrovascular dysfunction and inflammation occur in epilepsy. Here we asked whether pericytes, a pivotal cellular component of brain capillaries, undergo pathological modifications during experimental epileptogenesis and in human epilepsy ...
Wendy Klement +10 more
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