Results 41 to 50 of about 29,574 (291)

Differential pericyte pathology in the human retina and brain in diabetes mellitus and Alzheimer’s disease

Frontiers in Neuroscience
IntroductionIn diabetic retinopathy, pericyte dysfunction, pericyte loss, and inner blood–retinal barrier (iBRB) dysfunction contribute to neurovascular unit (NVU) impairment.
Noëlle Bakker-van Bugnum, Noëlle Bakker-van Bugnum, Noëlle Bakker-van Bugnum, Aïcha A. Croes, Eva Prevaes, Cornelis J. F. van Noorden, Reinier O. Schlingemann, Reinier O. Schlingemann, Reinier O. Schlingemann, Ingeborg Klaassen, Ingeborg Klaassen, Ingeborg Klaassen   +11 more
doaj   +1 more source

NeuroTrace 500/525 identifies human induced pluripotent stem cell-derived brain pericyte-like cells

Molecular Brain, 2022
In the CNS, pericytes are important for maintaining the blood–brain barrier (BBB) and for controlling blood flow. Recently, several methods were suggested for the differentiation of human pluripotent stem cells (hPSCs) into brain mural cells ...
Seo Young Kim, Jihye Choi, Junhee Roh, Chul Hoon Kim   +3 more
doaj   +1 more source

Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy

, 2008
OBJECTIVE: The mechanism underlying pericyte loss during incipient diabetic retinopathy remains controversial. Hyperglycemia induces angiopoietin-2 (Ang-2) transcription, which modulates capillary pericyte coverage.
vom Hagen, Franziska, Feng, Yuxi, Hammes, Hans-Peter, Hillebrands, Jan-Luuk; id_orcid, Shani, Moshe, Hagen, Franziska vom, Molema, Grietje; id_orcid, Hillebrands, Jan-Luuk, Hoffmann, Sigrid, Molema, Grietje, Pfister, Frederick, Deutsch, Urban   +11 more
core   +1 more source

Inhibition of VEGF‐Induced Angiogenesis and Vascular Leakage by Bicistronic Co‐Expression of Aflibercept and COMP‐Ang1

Advanced Healthcare Materials, EarlyView.
A bicistronic rAAV8 vector encoding Aflibercept (Afb) and COMP‐cAng1 simultaneously coordinates VEGF clearance and Tie2‐mediated vessel maturation. In a 3D angiogenesis‐on‐a‐chip model, rAAV8‐Afb/cAng1 effectively reverses pathological barrier breakdown under clinical disease‐mimicking challenges.
Bong‐Kyu Kim, Jaehong Min, Sang‐Hee Park, Subeen Shin, Sangbin Yu, Jeong‐Eun Park, Sujin Kim, Wooju Park, Jihoon Ko, Sunjong Kwon   +9 more
wiley   +1 more source

Extracellular matrix remodeling associated with bleomycin-induced lung injury supports pericyte-to-myofibroblast transition

Matrix Biology Plus, 2021
Of the many origins of pulmonary myofibroblasts, microvascular pericytes are a known source. Prior literature has established the ability of pericytes to transition into myofibroblasts, but provide limited insight into molecular cues that drive this ...
Riley T. Hannan, Andrew E. Miller, Ruei-Chun Hung, Catherine Sano, Shayn M. Peirce, Thomas H. Barker   +5 more
doaj   +1 more source

Pericytes in the infarcted heart [PDF]

Vascular Biology, 2019
The adult mammalian heart lacks regenerative capacity and heals through activation of an inflammatory cascade that leads to the formation of a collagen-based scar. Although scar formation is important to preserve the structural integrity of the ventricle, unrestrained inflammation and excessive fibrosis have been implicated in the pathogenesis of ...
Linda Alex, Nikolaos G Frangogiannis
openaire   +2 more sources

Colorectal cancer and primary fibroblast, pericyte conditioned media

, 2022
Proteomic profiling for 200 human cytokines of conditioned media samples as follows:PM = pericyte-conditioned pericyte mediaPCM = Caco2-conditioned pericyte mediaPSM = SW480-conditioned pericyte mediaPHM = HCT116-conditioned pericyte mediaFM = fibroblast-
Nairon, K (via Mendeley Data)
core   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion

Acta Neuropathologica Communications, 2019
Increasing evidence indicates that pericytes are vulnerable cells, playing pathophysiological roles in various neurodegenerative processes. Microvascular pericytes contract during cerebral and coronary ischemia and do not relax after re-opening of the ...
Luis Alarcon-Martinez, Sinem Yilmaz-Ozcan, Muge Yemisci, Jesse Schallek, Kıvılcım Kılıç, Deborah Villafranca-Baughman, Alp Can, Adriana Di Polo, Turgay Dalkara   +8 more
doaj   +1 more source

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source