Results 21 to 30 of about 30,427 (250)

Pericytes regulate vascular basement membrane remodeling and govern neutrophil extravasation during inflammation. [PDF]

PLoS ONE, 2012
During inflammation polymorphonuclear neutrophils (PMNs) traverse venular walls, composed of the endothelium, pericyte sheath and vascular basement membrane.
Shijun Wang, Canhong Cao, Zhongming Chen, Vytas Bankaitis, Eleni Tzima, Nader Sheibani, Keith Burridge   +6 more
doaj   +1 more source

Pericyte Loss in Diseases

Cells, 2023
Pericytes are specialized cells located in close proximity to endothelial cells within the microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls, and maintaining the integrity of the blood–brain barrier.
Pengfei Li, Hongkuan Fan
doaj   +1 more source

Brain pericytes upregulate glutamate uptake by astrocytes in vitro through sodium-dependent transporter

IBRO Neuroscience Reports
Astrocytes maintain glutamate homeostasis in the central nervous system (CNS) via glutamate uptake through Na+-dependent excitatory amino acid transporters (EAAT1 and EAAT2), and this process is regulated by several CNS cell types. However, it is unclear
Kenta Sakai, Fuyuko Takata, Takuro Iwao, Miho Yasunaga, Gaku Yamanaka, Yasufumi Kataoka, Shinya Dohgu   +6 more
doaj   +1 more source

Pathological pericyte expansion and impaired endothelial cell-pericyte communication in endothelial Rbpj deficient brain arteriovenous malformation

Frontiers in Human Neuroscience, 2022
Pericytes, like vascular smooth muscle cells, are perivascular cells closely associated with blood vessels throughout the body. Pericytes are necessary for vascular development and homeostasis, with particularly critical roles in the brain, where they ...
Samantha Selhorst, Samantha Selhorst, Sera Nakisli, Sera Nakisli, Shruthi Kandalai, Shruthi Kandalai, Subhodip Adhicary, Subhodip Adhicary, Corinne M. Nielsen, Corinne M. Nielsen, Corinne M. Nielsen   +10 more
doaj   +1 more source

Monitoring imatinib decreasing pericyte coverage and HIF-1α level in a colorectal cancer model by an ultrahigh-field multiparametric MRI approach

Journal of Translational Medicine
Background Excessive pericyte coverage promotes tumor growth, and a downregulation may solve this dilemma. Due to the double-edged sword role of vascular pericytes in tumor microenvironment (TME), indiscriminately decreasing pericyte coverage by imatinib
Xinpeng Hu, Kunlin Ye, Shaowei Bo, Zeyu Xiao, Mengjie Ma, Jinghua Pan, Xing Zhong, Dong Zhang, Xukai Mo, Xiaojun Yu, Minfeng Chen, Liangping Luo, Changzheng Shi   +12 more
doaj   +1 more source

Pericyte Structural Remodeling in Cerebrovascular Health and Homeostasis

Frontiers in Aging Neuroscience, 2018
The biology of brain microvascular pericytes is an active area of research and discovery, as their interaction with the endothelium is critical for multiple aspects of cerebrovascular function.
Andrée-Anne Berthiaume, David A. Hartmann, Mark W. Majesky, Mark W. Majesky, Narayan R. Bhat, Andy Y. Shih, Andy Y. Shih, Andy Y. Shih   +7 more
doaj   +1 more source

Emerging role of pericyte-expressed circPLOD2 in the regulation of capillary stability

, 2023
Glaser and colleagues characterized hypoxia-regulated circRNAs in pericytes and revealed the role of circPLOD2 in pericyte biology, endothelial-pericyte interactions, and vascular network formation.1 Understanding circPLOD2-regulatory network helps ...
Biao Yan
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The development of brain pericytes requires expression of the transcription factor nkx3.1 in intermediate precursors.

PLoS Biology
Brain pericytes are one of the critical cell types that regulate endothelial barrier function and activity, thus ensuring adequate blood flow to the brain. The genetic pathways guiding undifferentiated cells into mature pericytes are not well understood.
Suchit Ahuja, Cynthia Adjekukor, Qing Li, Katrinka M Kocha, Nicole Rosin, Elodie Labit, Sarthak Sinha, Ankita Narang, Quan Long, Jeff Biernaskie, Peng Huang, Sarah J Childs   +11 more
doaj   +1 more source

Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain

Cell Reports, 2018
Summary: Direct contact and communication between pericytes and endothelial cells is critical for maintenance of cerebrovascular stability and blood-brain barrier function.
Andrée-Anne Berthiaume, Roger I. Grant, Konnor P. McDowell, Robert G. Underly, David A. Hartmann, Manuel Levy, Narayan R. Bhat, Andy Y. Shih   +7 more
doaj   +1 more source