Results 31 to 40 of about 30,427 (250)
Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy
, 2008 OBJECTIVE: The mechanism underlying pericyte loss during incipient diabetic retinopathy remains controversial. Hyperglycemia induces angiopoietin-2 (Ang-2) transcription, which modulates capillary pericyte coverage.
vom Hagen, Franziska +11 more
core +1 more source
Complex mitochondrial morphology of a retinal deep capillary pericyte
, 2023 3D rendering of a pericyte mitochondria of a deep capillary exhibiting a convoluted shape. The mitochondrial loops and extensions follow the course of the pericyte processes wrapping the vessel ...
Deepayan Kar (16617657)
core +1 more source
Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali +4 more
wiley +1 more source
Frontiers in NeuroscienceIntroductionIn diabetic retinopathy, pericyte dysfunction, pericyte loss, and inner blood–retinal barrier (iBRB) dysfunction contribute to neurovascular unit (NVU) impairment.
Noëlle Bakker-van Bugnum +11 more
doaj +1 more source
Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling
Frontiers in Cellular Neuroscience, 2020 Pericytes are perivascular mural cells that enwrap brain capillaries and maintain blood-brain barrier (BBB) integrity. Most studies suggest that pericytes regulate cerebral blood flow (CBF) and oxygen delivery to activated brain structures, known as ...
Kassandra Kisler +6 more
doaj +1 more source
Pericytes Across the Lifetime in the Central Nervous System
Frontiers in Cellular Neuroscience, 2021 The pericyte is a perivascular cell type that encapsulates the microvasculature of the brain and spinal cord. Pericytes play a crucial role in the development and maintenance of the blood-brain barrier (BBB) and have a multitude of important functions in
Hannah C. Bennett, Yongsoo Kim
doaj +1 more source
Advanced Healthcare Materials, EarlyView.A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn +6 more
wiley +1 more source
Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration
Advanced Healthcare Materials, EarlyView.This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu +4 more
wiley +1 more source
Environmental Factors Influencing Tumor Associated Pericyte Phenotype in Pancreatic Cancer [PDF]
, 2021 Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the U.S. with a 5-year survival rate of 11%. PDAC patients suffer from the lack of effective treatment options largely due to the limited delivery efficacy of the drugs.
Delgado, Alexander
core
Advanced Healthcare Materials, EarlyView.This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar +2 more
wiley +1 more source