Pericytes regulate vascular basement membrane remodeling and govern neutrophil extravasation during inflammation. [PDF]
PLoS ONE, 2012 During inflammation polymorphonuclear neutrophils (PMNs) traverse venular walls, composed of the endothelium, pericyte sheath and vascular basement membrane.
Shijun Wang +6 more
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Frontiers in Physiology, 2023 Pericytes are a heterogeneous population of mesenchymal cells located on the abluminal surface of microvessels, where they provide structural and biochemical support. Pericytes have been implicated in numerous lung diseases including pulmonary arterial hypertension (PAH) and allergic asthma due to their ability to differentiate into scar-forming ...
Garrison, Annelise T. +3 more
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Functional deficits precede structural lesions in mice with high-fat diet-induced diabetic retinopathy [PDF]
, 2016 Obesity predisposes to human type 2 diabetes, the most common cause of diabetic retinopathy. To determine if high-fat diet–induced diabetes in mice can model retinal disease, we weaned mice to chow or a high-fat diet and tested the hypothesis that diet ...
Bligard, Gregory W +5 more
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Current Perspective on the Location and Function of Gamma- Aminobutyric Acid (GABA) and its Metabolic Partners in the Kidney. [PDF]
, 2014 Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter located in the mammalian central nervous system, which binds to GABAA and GABAB receptors to mediate its neurological effects.
Dunn, Kadeshia +3 more
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Pflügers Archiv - European Journal of Physiology, 2013 Pericytes were originally discovered more than100 years ago as contractile cells surrounding the endothelial cells of small blood vessels. Anatomists have later on strictly defined pericytes as cells sharing a basal membrane with the endothelium.
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Frontiers in Human Neuroscience, 2022 Pericytes, like vascular smooth muscle cells, are perivascular cells closely associated with blood vessels throughout the body. Pericytes are necessary for vascular development and homeostasis, with particularly critical roles in the brain, where they ...
Samantha Selhorst +10 more
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RET mutation and increased angiogenesis in medullary thyroid carcinomas [PDF]
, 2016 Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis.
Acquaviva, Giorgia +16 more
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Pretreatment with VEGF(R)-inhibitors reduces interstitial fluid pressure, increases intraperitoneal chemotherapy drug penetration, and impedes tumor growth in a mouse colorectal carcinomatosis model [PDF]
, 2015 Cytoreductive surgery combined with intraperitoneal chemotherapy (IPC) is currently the standard treatment for selected patients with peritoneal carcinomatosis of colorectal cancer.
Ceelen, Wim +6 more
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Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke. [PDF]
, 2018 Stroke is the primary cause of disability due to the brain's limited ability to regenerate damaged tissue. After stroke, an increased inflammatory and immune response coupled with severely limited angiogenesis and neuronal growth results in a stroke ...
Carmichael, S Thomas +3 more
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Pericytes in the infarcted heart [PDF]
Vascular Biology, 2019 The adult mammalian heart lacks regenerative capacity and heals through activation of an inflammatory cascade that leads to the formation of a collagen-based scar. Although scar formation is important to preserve the structural integrity of the ventricle, unrestrained inflammation and excessive fibrosis have been implicated in the pathogenesis of ...
Linda Alex, Nikolaos G Frangogiannis
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