Results 31 to 40 of about 29,574 (291)

Brain pericytes upregulate glutamate uptake by astrocytes in vitro through sodium-dependent transporter

IBRO Neuroscience Reports
Astrocytes maintain glutamate homeostasis in the central nervous system (CNS) via glutamate uptake through Na+-dependent excitatory amino acid transporters (EAAT1 and EAAT2), and this process is regulated by several CNS cell types. However, it is unclear
Kenta Sakai, Fuyuko Takata, Takuro Iwao, Miho Yasunaga, Gaku Yamanaka, Yasufumi Kataoka, Shinya Dohgu   +6 more
doaj   +1 more source

Pericyte Structural Remodeling in Cerebrovascular Health and Homeostasis

Frontiers in Aging Neuroscience, 2018
The biology of brain microvascular pericytes is an active area of research and discovery, as their interaction with the endothelium is critical for multiple aspects of cerebrovascular function.
Andrée-Anne Berthiaume, David A. Hartmann, Mark W. Majesky, Mark W. Majesky, Narayan R. Bhat, Andy Y. Shih, Andy Y. Shih, Andy Y. Shih   +7 more
doaj   +1 more source

Pericytes Across the Lifetime in the Central Nervous System

Frontiers in Cellular Neuroscience, 2021
The pericyte is a perivascular cell type that encapsulates the microvasculature of the brain and spinal cord. Pericytes play a crucial role in the development and maintenance of the blood-brain barrier (BBB) and have a multitude of important functions in
Hannah C. Bennett, Yongsoo Kim
doaj   +1 more source

Monitoring imatinib decreasing pericyte coverage and HIF-1α level in a colorectal cancer model by an ultrahigh-field multiparametric MRI approach

Journal of Translational Medicine
Background Excessive pericyte coverage promotes tumor growth, and a downregulation may solve this dilemma. Due to the double-edged sword role of vascular pericytes in tumor microenvironment (TME), indiscriminately decreasing pericyte coverage by imatinib
Xinpeng Hu, Kunlin Ye, Shaowei Bo, Zeyu Xiao, Mengjie Ma, Jinghua Pan, Xing Zhong, Dong Zhang, Xukai Mo, Xiaojun Yu, Minfeng Chen, Liangping Luo, Changzheng Shi   +12 more
doaj   +1 more source

Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain

Cell Reports, 2018
Summary: Direct contact and communication between pericytes and endothelial cells is critical for maintenance of cerebrovascular stability and blood-brain barrier function.
Andrée-Anne Berthiaume, Roger I. Grant, Konnor P. McDowell, Robert G. Underly, David A. Hartmann, Manuel Levy, Narayan R. Bhat, Andy Y. Shih   +7 more
doaj   +1 more source

Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling

Frontiers in Cellular Neuroscience, 2020
Pericytes are perivascular mural cells that enwrap brain capillaries and maintain blood-brain barrier (BBB) integrity. Most studies suggest that pericytes regulate cerebral blood flow (CBF) and oxygen delivery to activated brain structures, known as ...
Kassandra Kisler, Angeliki M. Nikolakopoulou, Melanie D. Sweeney, Divna Lazic, Divna Lazic, Zhen Zhao, Berislav V. Zlokovic   +6 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The development of brain pericytes requires expression of the transcription factor nkx3.1 in intermediate precursors.

PLoS Biology
Brain pericytes are one of the critical cell types that regulate endothelial barrier function and activity, thus ensuring adequate blood flow to the brain. The genetic pathways guiding undifferentiated cells into mature pericytes are not well understood.
Suchit Ahuja, Cynthia Adjekukor, Qing Li, Katrinka M Kocha, Nicole Rosin, Elodie Labit, Sarthak Sinha, Ankita Narang, Quan Long, Jeff Biernaskie, Peng Huang, Sarah J Childs   +11 more
doaj   +1 more source

The pericyte response to ischemic stroke [PDF]

, 2021
Pericytes are a previously understudied, but crucial cell type of the vessel wall. In the brain, pericytes are part of the neurovascular unit and are involved in the control and regulation of cerebral blood flow, formation and maintenance of the blood ...
Shrouder, Joshua James
core   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source