Results 51 to 60 of about 30,427 (250)

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Pericyte pannexin1 controls cerebral capillary diameter and supports memory function

Nature Communications
In the blood-brain-barrier, contractile pericytes fine-tune the capillary resistance and blood supply to meet neuro-metabolic demands; molecular players governing these functions remain unclear.
Sandra Mai-Morente, Eugenia Isasi, Alberto Rafael, Gonzalo Budelli, Silvia Olivera-Bravo, Nathalia Vitureira, Verónica Abudara   +6 more
doaj   +1 more source

2313 Characterization of the host pericyte role in glioblastoma angiogenesis

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: Glioblastoma (GBM) carries a prognosis of 14.6 months mean survival despite maximal surgical, chemotherapeutic, and radiation therapy.
Frank Attenello, Frank Attenello, Yingxi Wu, Kathleen Tsung, William Mack, Thomas Chen, Berislav Zlokovic   +6 more
doaj   +1 more source

Pericyte-Derived MFG-E8 Regulates Pathologic Angiogenesis

, 2011
Objective— MFG-E8 (also called lactadherin and SED1) is a secreted glycoprotein that has been previously implicated in enhancement of vascular endothelial growth factor–dependent angiogenesis.
Yayoi Tada, Triantafyllos Chavakis, Mark C. Udey, Sei-ichiro Motegi, Michael Lu, Miklós Sárdy, Chuanjin Wu, Wolfgang W. Leitner   +7 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

The pericyte: A critical cell in the pathogenesis of CADASIL [PDF]

, 2021
\ua9 2021. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small vessel disease presenting with migraine, mood and cognitive disorders, focal neurological deficits, recurrent ischemic ...
Roman GC, Kalaria RN, Ruchoux M-M
core   +1 more source

Endothelial survival factors and spatial completion, but not pericyte coverage of retinal capillaries determine vessel plasticity

, 2005
Pericyte loss and capillary regression are characteristic for incipient diabetic retinopathy. Pericyte recruitment is involved in vessel maturation, and ligand-receptor systems contributing to pericyte recruitment are survival factors for endothelial ...
Vajkoczy, P., Preissner, K., Giannis, A, Feng, Y, Hoffmann, J., Weich, HA, Erber, R, Jaeger, V, Shani, M., vom Hagen, F., Hoffmann, J, Vajkoczy, P, Hillenbrand, A., vom Hagen, F, Deutsch, U, Hillenbrand, A, Hammes, HP, Gourzoulidou, E, Feng, Y., Lin, J., Waldmann, H., Gourzoulidou, E., Jaeger, V., Lin, J, Hoffmann, S, Waldmann, H, Hoffmann, S., Wolburg, H., Giannis, A., Deutsch, U., Wolburg, H, Shani, M, Preissner, KT, Erber, R., Weich, H., Hammes, H., Deutsch, Urban   +36 more
core   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

, 2019
Pericytes are positioned between brain capillary endothelial cells, astrocytes and neurons. They degenerate in multiple neurological disorders. However, their role in the pathogenesis of these disorders remains debatable.
Zhen Zhao, Dai, Zhonghua, Lawson, Erica J., Berislav V. Zlokovic, Huuskonen, Mikko T., Zloković, Berislav V., Xie, Xiaochun, Wang, Yaoming, Min Wang, Kassandra Kisler, Zhao, Zhen, Mikko T. Huuskonen, Nelly Chuqui Owens, Lazić, Divna, Axel Montagne, Sagare, Abhay P., Nikolakopoulou, Angeliki M., Abhay P. Sagare, Zhonghua Dai, Xiaochun Xie, Kisler, Kassandra, Sweeney, Melanie D., Montagne, Axel, Erica J. Lawson, Pan Kong, Angeliki M. Nikolakopoulou, Kong, Pan, Yaoming Wang, Melanie D. Sweeney, Wang, Min, Divna Lazic, Owens, Nelly Chuqui   +31 more
core   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source