Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism [PDF]
Molecular Neurodegeneration, 2018 Background Clearance at the blood-brain barrier (BBB) plays an important role in removal of Alzheimer’s amyloid-β (Aβ) toxin from brain both in humans and animal models. Apolipoprotein E (apoE), the major genetic risk factor for AD, disrupts Aβ clearance
Qingyi Ma +9 more
doaj +4 more sources
Brain-derived neurotrophic factor supports pericyte and vascular homeostasis in the aging brain [PDF]
Acta Neuropathologica CommunicationsMicrovascular circulation in the brain is often impaired in connection with the loss of pericytes in old age. The neurotrophic factor BDNF also decreases in the aging brain.
Qinghua Luo +9 more
doaj +2 more sources
Pericytes and Neurovascular Function in the Healthy and Diseased Brain
Frontiers in Cellular Neuroscience, 2019 Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the 1870s, but little attention was paid to them during the following century.
Lachlan S Brown +2 more
exaly +3 more sources
Pericytes for Therapeutic Approaches to Ischemic Stroke
Frontiers in Neuroscience, 2021 Pericytes are perivascular multipotent cells located on capillaries. Although pericytes are discovered in the nineteenth century, recent studies have found that pericytes play an important role in maintaining the blood—brain barrier (BBB) and regulating ...
Lu Cao +4 more
doaj +1 more source
The Neuroinflammatory Role of Pericytes in Epilepsy
Biomedicines, 2021 Pericytes are a component of the blood–brain barrier (BBB) neurovascular unit, in which they play a crucial role in BBB integrity and are also implicated in neuroinflammation. The association between pericytes, BBB dysfunction, and the pathophysiology of
Gaku Yamanaka +6 more
doaj +1 more source
Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications [PDF]
, 2020 Pericytes are mural vascular cells found predominantly on the abluminal wall of capillaries, where they contribute to the maintenance of capillary structural integrity and vascular permeability. Generally quiescent cells in the adult, pericyte activation
Haas, Tara +2 more
core +1 more source
Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. [PDF]
, 2013 We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors.
Chillo, Omary +6 more
core +11 more sources
Descending Vasa Recta Endothelial Membrane Potential Response Requires Pericyte Communication. [PDF]
PLoS ONE, 2016 Using dual-cell electrophysiological recording, we examined the routes for equilibration of membrane potential between the pericytes and endothelia that comprise the descending vasa recta (DVR) wall.
Zhong Zhang +2 more
doaj +1 more source
Pericytes as mediators of infiltration of macrophages in multiple sclerosis
Journal of Neuroinflammation, 2021 Background Multiple sclerosis (MS) is a neurodegenerative condition of the central nervous system (CNS). It is associated with blood–brain barrier (BBB) breakdown and intravasation of leukocytes, particularly monocyte-derived macrophages, into the CNS ...
Deepak Kumar Kaushik +3 more
doaj +1 more source
The Role of Pericytes in Regulation of Innate and Adaptive Immunity
Biomedicines, 2023 Pericytes are perivascular multipotent cells wrapping microvascular capillaries, where they support vasculature functioning, participate in tissue regeneration, and regulate blood flow.
Siarhei A. Dabravolski +6 more
doaj +1 more source