Pericytes for Therapeutic Approaches to Ischemic Stroke
Frontiers in Neuroscience, 2021 Pericytes are perivascular multipotent cells located on capillaries. Although pericytes are discovered in the nineteenth century, recent studies have found that pericytes play an important role in maintaining the blood—brain barrier (BBB) and regulating ...
Lu Cao +4 more
exaly +3 more sources
The Neuroinflammatory Role of Pericytes in Epilepsy
Biomedicines, 2021 Pericytes are a component of the blood–brain barrier (BBB) neurovascular unit, in which they play a crucial role in BBB integrity and are also implicated in neuroinflammation. The association between pericytes, BBB dysfunction, and the pathophysiology of
Gaku Yamanaka +2 more
exaly +3 more sources
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism [PDF]
Molecular Neurodegeneration, 2018 Background Clearance at the blood-brain barrier (BBB) plays an important role in removal of Alzheimer’s amyloid-β (Aβ) toxin from brain both in humans and animal models. Apolipoprotein E (apoE), the major genetic risk factor for AD, disrupts Aβ clearance
Qingyi Ma +9 more
doaj +2 more sources
Pericytes and Neurovascular Function in the Healthy and Diseased Brain
Frontiers in Cellular Neuroscience, 2019 Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the 1870s, but little attention was paid to them during the following century.
Lachlan S Brown +2 more
exaly +3 more sources
The Role of Pericytes in Regulation of Innate and Adaptive Immunity
Biomedicines, 2023 Pericytes are perivascular multipotent cells wrapping microvascular capillaries, where they support vasculature functioning, participate in tissue regeneration, and regulate blood flow.
Siarhei A. Dabravolski +6 more
doaj +1 more source
Pericytes as mediators of infiltration of macrophages in multiple sclerosis
Journal of Neuroinflammation, 2021 Background Multiple sclerosis (MS) is a neurodegenerative condition of the central nervous system (CNS). It is associated with blood–brain barrier (BBB) breakdown and intravasation of leukocytes, particularly monocyte-derived macrophages, into the CNS ...
Deepak Kumar Kaushik +3 more
doaj +1 more source
Descending Vasa Recta Endothelial Membrane Potential Response Requires Pericyte Communication. [PDF]
PLoS ONE, 2016 Using dual-cell electrophysiological recording, we examined the routes for equilibration of membrane potential between the pericytes and endothelia that comprise the descending vasa recta (DVR) wall.
Zhong Zhang +2 more
doaj +1 more source
Matricellular Protein Periostin Promotes Pericyte Migration in Fibrotic Airways
Frontiers in Allergy, 2021 Introduction: Periostin is a matricellular protein that is currently used as a biomarker for asthma. However, its contribution to tissue remodeling in allergic asthma is currently unknown.
Rebecca E. Bignold, Jill R. Johnson
doaj +1 more source
Tissue Specific Origin, Development, and Pathological Perspectives of Pericytes
Frontiers in Cardiovascular Medicine, 2018 Pericytes are mural cells surrounding blood vessels, adjacent to endothelial cells. Pericytes play critical roles in maturation and maintenance of vascular branching morphogenesis.
Tomoko Yamazaki +2 more
doaj +1 more source
Emerging Role of Pericytes and Their Secretome in the Heart
Cells, 2021 Pericytes, as mural cells covering microvascular capillaries, play an essential role in vascular remodeling and maintaining vascular functions and blood flow.
Han Su +4 more
doaj +1 more source