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Pericytes for Therapeutic Approaches to Ischemic Stroke [PDF]
Frontiers in Neuroscience, 2021 Pericytes are perivascular multipotent cells located on capillaries. Although pericytes are discovered in the nineteenth century, recent studies have found that pericytes play an important role in maintaining the blood—brain barrier (BBB) and regulating ...
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The Neuroinflammatory Role of Pericytes in Epilepsy [PDF]
Biomedicines, 2021 Pericytes are a component of the blood–brain barrier (BBB) neurovascular unit, in which they play a crucial role in BBB integrity and are also implicated in neuroinflammation. The association between pericytes, BBB dysfunction, and the pathophysiology of
Shinichiro Morichi +2 more
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Pericytes and Neurovascular Function in the Healthy and Diseased Brain [PDF]
Frontiers in Cellular Neuroscience, 2019 Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the 1870s, but little attention was paid to them during the following century.
Natalie KING +2 more
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Pericytes in the microvasculature [PDF]
Cardiovascular Research, 1996 Pericytes, also known as Rouget cells or mural cells, are associated abluminally with all vascular capillaries and post-capillary venules. Differences in pericyte morphology and distribution among vascular beds suggest tissue-specific functions. Based on their location and their complement of muscle cytoskeletal proteins, pericytes have been proposed ...
Karen Hirschi +2 more
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Pericytes in the tumor microenvironment
Cancer Letters, 2023 Pericytes are a type of mural cell located between the endothelial cells of capillaries and the basement membrane, which function to regulate the capillary vasomotor and maintain normal microcirculation of local tissues and organs and have been identified as a significant component in the tumor microenvironment (TME).
Yanhong Zhou, Shan Liao
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EBF1 is expressed in pericytes and contributes to pericyte cell commitment [PDF]
Histochemistry and Cell Biology, 2021 AbstractEarly B-cell factor-1 (EBF1) is a transcription factor with an important role in cell lineage specification and commitment during the early stage of cell maturation. Originally described during B-cell maturation, EBF1 was subsequently identified as a crucial molecule for proper cell fate commitment of mesenchymal stem cells into adipocytes ...
Pagani F. +4 more
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The Role of Pericytes in Regulation of Innate and Adaptive Immunity
Biomedicines, 2023 Pericytes are perivascular multipotent cells wrapping microvascular capillaries, where they support vasculature functioning, participate in tissue regeneration, and regulate blood flow.
Siarhei A. Dabravolski +6 more
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Pericytes as mediators of infiltration of macrophages in multiple sclerosis
Journal of Neuroinflammation, 2021 Background Multiple sclerosis (MS) is a neurodegenerative condition of the central nervous system (CNS). It is associated with blood–brain barrier (BBB) breakdown and intravasation of leukocytes, particularly monocyte-derived macrophages, into the CNS ...
Deepak Kumar Kaushik +3 more
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Matricellular Protein Periostin Promotes Pericyte Migration in Fibrotic Airways
Frontiers in Allergy, 2021 Introduction: Periostin is a matricellular protein that is currently used as a biomarker for asthma. However, its contribution to tissue remodeling in allergic asthma is currently unknown.
Rebecca E. Bignold, Jill R. Johnson
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Microcirculation, 2008 ABSTRACTObjectives: Cochlear pericytes are not well characterized. The aim of this study was to further advance the characterization of cochlear pericyte location and distribution, with particular focus on pericyte‐related proteins on the capillaries of the cochlear lateral wall that are functionally integral to structure, contraction, and gap junction
Xiaorui, Shi +7 more
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