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Pericytes were originally discovered more than100 years ago as contractile cells surrounding the endothelial cells of small blood vessels. Anatomists have later on strictly defined pericytes as cells sharing a basal membrane with the endothelium.
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Pericytes are specialized cells located in close proximity to endothelial cells within the microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls, and maintaining the integrity of the blood–brain barrier. The loss of pericytes has been associated with the development and progression of various diseases, such as ...
Pengfei Li, Hongkuan Fan
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Pericytes play an indispensable role in various organs and biological processes, such as promoting angiogenesis, regulating microvascular blood flow, and participating in immune responses.
Jiaqi Fu +6 more
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Pulmonary pericytes regulate lung morphogenesis [PDF]
Blood vessels are essential for blood circulation but also control organ growth, homeostasis, and regeneration, which has been attributed to the release of paracrine signals by endothelial cells.
Adams S. +10 more
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Pericytes are a heterogeneous population of mesenchymal cells located on the abluminal surface of microvessels, where they provide structural and biochemical support. Pericytes have been implicated in numerous lung diseases including pulmonary arterial hypertension (PAH) and allergic asthma due to their ability to differentiate into scar-forming ...
Garrison, Annelise T. +3 more
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Pericytes in the infarcted heart [PDF]
The adult mammalian heart lacks regenerative capacity and heals through activation of an inflammatory cascade that leads to the formation of a collagen-based scar. Although scar formation is important to preserve the structural integrity of the ventricle, unrestrained inflammation and excessive fibrosis have been implicated in the pathogenesis of ...
Linda Alex, Nikolaos G Frangogiannis
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Improvement of Neurological Function in Rats with Ischemic Stroke by Adipose-derived Pericytes
Pericytes possess high multipotent features and cell plasticity, and produce angiogenic and neurotrophic factors that indicate their high regenerative potential.
Vyacheslav Ogay +15 more
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Objective To investigate the role of pericyte ferroptosis in the injury of pulmonary vascular barrier in septic rats and identify the protective effect of ferrostatin-1 (Fer-1), a ferroptosis inhibitor, on pulmonary vascular barrier function.
LIU Yiyan +5 more
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Calcium Signalling in Pericytes [PDF]
Recent advances in pericyte research have contributed to our understanding of the physiology and pathophysiology of microvessels. The microvasculature consists of arteriolar and venular networks located upstream and downstream of the capillaries.
Theodor, Burdyga, Lyudmyla, Borysova
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Characterization of Burn Eschar Pericytes
Pericytes are cells that reside adjacent to microvasculature and regulate vascular function. Pericytes gained great interest in the field of wound healing and regenerative medicine due to their multipotential fate and ability to enhance angiogenesis.
Onur Kanisicak +7 more
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