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Cells, 2023 Pericytes are specialized cells located in close proximity to endothelial cells within the microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls, and maintaining the integrity of the blood–brain barrier. The loss of pericytes has been associated with the development and progression of various diseases, such as ...
Pengfei Li, Hongkuan Fan
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Frontiers in Cellular Neuroscience, 2023 Pericytes play an indispensable role in various organs and biological processes, such as promoting angiogenesis, regulating microvascular blood flow, and participating in immune responses.
Jiaqi Fu +6 more
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Frontiers in Physiology, 2023 Pericytes are a heterogeneous population of mesenchymal cells located on the abluminal surface of microvessels, where they provide structural and biochemical support. Pericytes have been implicated in numerous lung diseases including pulmonary arterial hypertension (PAH) and allergic asthma due to their ability to differentiate into scar-forming ...
Garrison, Annelise T. +3 more
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Pflügers Archiv - European Journal of Physiology, 2013 Pericytes were originally discovered more than100 years ago as contractile cells surrounding the endothelial cells of small blood vessels. Anatomists have later on strictly defined pericytes as cells sharing a basal membrane with the endothelium.
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Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications [PDF]
Pericytes are mural vascular cells found predominantly on the abluminal wall of capillaries, where they contribute to the maintenance of capillary structural integrity and vascular permeability. Generally quiescent cells in the adult, pericyte activation
Haas, Tara +2 more
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Renal pericytes: regulators of medullary blood flow [PDF]
Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli.
Agmon Y. +27 more
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Immune regulation by pericytes: modulating innate and adaptive immunity
Frontiers in Immunology, 2016 Pericytes are mural cells that surround endothelial cells in small blood vessels. Pericytes have traditionally been credited with structural functions, being essential for vessel maturation and stabilization.
Rocio Navarro +3 more
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Sympathetic nerve-derived ATP regulates renal medullary vasa recta diameter via pericyte cells: a role for regulating medullary blood flow? [PDF]
Pericyte cells are now known to be a novel locus of blood flow control, being able to regulate capillary diameter via their unique morphology and expression of contractile proteins.
Crawford, C. +4 more
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Pericytes in the infarcted heart [PDF]
Vascular Biology, 2019 The adult mammalian heart lacks regenerative capacity and heals through activation of an inflammatory cascade that leads to the formation of a collagen-based scar. Although scar formation is important to preserve the structural integrity of the ventricle, unrestrained inflammation and excessive fibrosis have been implicated in the pathogenesis of ...
Linda Alex, Nikolaos G Frangogiannis
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iScienceSummary: Systemic sclerosis (SSc) is a chronic disease characterized by fibrosis and vascular abnormalities in the skin and internal organs, including the lung.
Ludivine Renaud +4 more
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