Results 71 to 80 of about 27,494 (299)

2313 Characterization of the host pericyte role in glioblastoma angiogenesis

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: Glioblastoma (GBM) carries a prognosis of 14.6 months mean survival despite maximal surgical, chemotherapeutic, and radiation therapy.
Frank Attenello, Frank Attenello, Yingxi Wu, Kathleen Tsung, William Mack, Thomas Chen, Berislav Zlokovic   +6 more
doaj   +1 more source

Pericytes in the tumor microenvironment

Cancer Letters, 2023
Pericytes are a type of mural cell located between the endothelial cells of capillaries and the basement membrane, which function to regulate the capillary vasomotor and maintain normal microcirculation of local tissues and organs and have been identified as a significant component in the tumor microenvironment (TME).
Zhongyi, Jiang, Jing, Zhou, Luohong, Li, Shan, Liao, Junyu, He, Shubo, Zhou, Yanhong, Zhou   +6 more
openaire   +2 more sources

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Endothelial survival factors and spatial completion, but not pericyte coverage of retinal capillaries determine vessel plasticity

, 2005
Pericyte loss and capillary regression are characteristic for incipient diabetic retinopathy. Pericyte recruitment is involved in vessel maturation, and ligand-receptor systems contributing to pericyte recruitment are survival factors for endothelial ...
Vajkoczy, P., Preissner, K., Preissner, K. T., Giannis, A, Feng, Y, Waldmann, Herbert, Hoffmann, J., Weich, HA, Erber, R, Jaeger, V, Shani, M., vom Hagen, F., Hoffmann, J, Vajkoczy, P, Hillenbrand, A., Weich, H. A., vom Hagen, F, Hammes, Hans-Peter, Deutsch, U, Hillenbrand, A, Hammes, HP, Gourzoulidou, E, Feng, Y., Lin, J., Waldmann, H., Gourzoulidou, E., Jaeger, V., Lin, J, Hoffmann, S, Waldmann, H, Hoffmann, S., Wolburg, H., Gourzoulidou, Eleni, Giannis, Athanassios, Giannis, A., Deutsch, U., Wolburg, H, Shani, M, Preissner, KT, Erber, R., Weich, H., Hammes, H.   +41 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Pericyte-to-Endothelial Cell Communication via Tunneling Nanotubes Is Disrupted by a Diol of Docosahexaenoic Acid

Cells
The pericyte coverage of microvessels is altered in metabolic diseases, but the mechanisms regulating pericyte–endothelial cell communication remain unclear.
Sebastian Kempf, Rüdiger Popp, Zumer Naeem, Timo Frömel, Ilka Wittig, Stephan Klatt, Ingrid Fleming   +6 more
doaj   +1 more source

Effect of vasoactive drugs, NE and Tolazoline, on pericyte morphology and permeability of pericyte monolayers.

, 2012
(A) Mouse primary pericytes were treated with buffer, NE or Tolazoline. Cells were fixed and stained for F-actin, paxillin and nuclei. Bar = 10 µm. (B) NE increased RhoA activity in pericytes while Tolazoline inhibited it.
Shijun Wang (89455), Vytas Bankaitis (135052), Canhong Cao (135044), Eleni Tzima (135056), Keith Burridge (106396), Zhongming Chen (135048), Nader Sheibani (135061)   +6 more
core   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Pericyte pannexin1 controls cerebral capillary diameter and supports memory function

Nature Communications
In the blood-brain-barrier, contractile pericytes fine-tune the capillary resistance and blood supply to meet neuro-metabolic demands; molecular players governing these functions remain unclear.
Sandra Mai-Morente, Eugenia Isasi, Alberto Rafael, Gonzalo Budelli, Silvia Olivera-Bravo, Nathalia Vitureira, Verónica Abudara   +6 more
doaj   +1 more source

Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction

JACC: Basic to Translational Science, 2023
Summary: Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at
Sanjiv Kaul, MD, Carmen Methner, PhD, Zhiping Cao, PhD, Anusha Mishra, PhD   +3 more
doaj   +1 more source