Results 71 to 80 of about 29,574 (291)

Role of microvascular pericyte dysfunction in antibody-mediated rejection following kidney transplantation

Renal Failure
Objective To investigate the role of microvascular pericyte dysfunction in antibody-mediated rejection (ABMR) of transplanted kidneys.Methods A total of 160 patients who underwent kidney transplantation in our hospital from 2004 to 2020 were enrolled ...
Jie Xu, Junyan Pu, Hao Chen, Li Sun, Shuang Fei, Zhijian Han, Jun Tao, Xiaobing Ju, Zijie Wang, Ruoyun Tan, Min Gu   +10 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

Advanced Science
Pericytes exhibits distinct morphological features on microvessels during various stages of brain‐blood barrier (BBB) development and neurological disorders. However, the underlying mechanisms by which pericyte morphology influences BBB integrity are not
Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, Yue Dai, Zhao‐You Meng, Chen‐Hao Zhao, Bao‐Liang Sun, Qi Xie, Fang‐Fei Li, Qing‐Wu Yang   +16 more
doaj   +1 more source

Relaxation of pericytes expands pericyte gaps in a pericyte monolayer.

, 2012
(A)–(C) On the left, the relative impedance is shown for pericytes responding to different treatments. Representative real-time read-outs are shown on the right. The relative impedance at 1 hour after adding a chemical (indicated by the red vertical line)
Shijun Wang (89455), Vytas Bankaitis (135052), Canhong Cao (135044), Eleni Tzima (135056), Keith Burridge (106396), Zhongming Chen (135048), Nader Sheibani (135061)   +6 more
core   +1 more source

Environmental Factors Influencing Tumor Associated Pericyte Phenotype in Pancreatic Cancer [PDF]

, 2021
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the U.S. with a 5-year survival rate of 11%. PDAC patients suffer from the lack of effective treatment options largely due to the limited delivery efficacy of the drugs.
Delgado, Alexander
core  

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Pericyte signaling via soluble guanylate cyclase shapes the vascular niche and microenvironment of tumors

The EMBO Journal
Pericytes and endothelial cells (ECs) constitute the fundamental components of blood vessels. While the role of ECs in tumor angiogenesis and the tumor microenvironment is well appreciated, pericyte function in tumors remains underexplored. In this study,
Jing Zhu, Wu Yang, Jianyun Ma, Hao He, Zhen Liu, Xiaolan Zhu, Xueyang He, Jing He, Zhan Chen, Xiaoliang Jin, Xiaohong Wang, Kaiwen He, Wu Wei, Junhao Hu   +13 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Transcriptome analysis reveals microvascular endothelial cell-dependent pericyte differentiation [PDF]

, 2019
Microvascular homeostasis is strictly regulated, requiring close interaction between endothelial cells and pericytes. Here, we aimed to improve our understanding of how microvascular crosstalk affects pericytes.
Kramann, R.J.T. (Rafael), Duncker, D.J.G.M. (Dirk), Maringanti, R. (Ranganath), Verhaar, M.C. (Marianne), Brandt, M.M. (Maarten), Van Dijk, C.G.M. (Christian G.M.), Cheng, C. (Caroline), Chrifi, I. (Ihsane), Mokry, M. (Michal)   +8 more
core   +5 more sources

Quality Thresholds for Angiogenesis Under Acoustic Manipulation in Engineered Vascular Tissues

Advanced Science, EarlyView.
Defined biological and physical quality thresholds achieved through acoustic manipulation regulate cellular alignment and spatial organization, promoting self‐assembling vasculature, extracellular matrix deposition, and angiogenic responses, thereby establishing critical acoustic patterning requirements for engineered vascular tissue development in ...
Oscar O'Dwyer Lancaster‐Jones, Russell Quinn, Niloofar Khoshdel Rad, Kilian Paul, Andrea Frank, Daniela F. Duarte Campos   +5 more
wiley   +1 more source