Results 71 to 80 of about 39,702 (305)

Pericyte actomyosin-mediated contraction at the cell-material interface can modulate the microvascular niche [PDF]

, 2009
Pericytes physically surround the capillary endothelium, contacting and communicating with associated vascular endothelial cells via cell–cell and cell–matrix contacts. Pericyte–endothelial cell interactions thus have the potential to modulate growth and
Adam Zeiger, Bondjers C, Burton K, Butt H J, Davis M J, Davis M J, Falcone J C, Ira M Herman, John M Maloney, Krystyn J Van Vliet, Maciej Kotecki, Papetti M, Saitoh M, Shukla A, Sunyoung Lee, Vasquez R J, Welling L   +16 more
core   +1 more source

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Pericyte pannexin1 controls cerebral capillary diameter and supports memory function

Nature Communications
In the blood-brain-barrier, contractile pericytes fine-tune the capillary resistance and blood supply to meet neuro-metabolic demands; molecular players governing these functions remain unclear.
Sandra Mai-Morente, Eugenia Isasi, Alberto Rafael, Gonzalo Budelli, Silvia Olivera-Bravo, Nathalia Vitureira, Verónica Abudara   +6 more
doaj   +1 more source

Pericyte-to-Endothelial Cell Communication via Tunneling Nanotubes Is Disrupted by a Diol of Docosahexaenoic Acid

Cells
The pericyte coverage of microvessels is altered in metabolic diseases, but the mechanisms regulating pericyte–endothelial cell communication remain unclear.
Sebastian Kempf, Rüdiger Popp, Zumer Naeem, Timo Frömel, Ilka Wittig, Stephan Klatt, Ingrid Fleming   +6 more
doaj   +1 more source

Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction

JACC: Basic to Translational Science, 2023
Summary: Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at
Sanjiv Kaul, MD, Carmen Methner, PhD, Zhiping Cao, PhD, Anusha Mishra, PhD   +3 more
doaj   +1 more source

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

Role of microvascular pericyte dysfunction in antibody-mediated rejection following kidney transplantation

Renal Failure
Objective To investigate the role of microvascular pericyte dysfunction in antibody-mediated rejection (ABMR) of transplanted kidneys.Methods A total of 160 patients who underwent kidney transplantation in our hospital from 2004 to 2020 were enrolled ...
Jie Xu, Junyan Pu, Hao Chen, Li Sun, Shuang Fei, Zhijian Han, Jun Tao, Xiaobing Ju, Zijie Wang, Ruoyun Tan, Min Gu   +10 more
doaj   +1 more source

Deficiency of Notch signaling in pericytes results in arteriovenous malformations

JCI Insight, 2020
Arteriovenous malformations (AVMs) are high-flow lesions directly connecting arteries and veins. In the brain, AVM rupture can cause seizures, stroke, and death.
Taliha Nadeem, Wil Bogue, Bianca Bigit, Henar Cuervo   +3 more
doaj   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

ORGAN SPECIFIC VASCULAR RESPONSE TO FIBROSIS AFFECTS BREAST CANCER METASTATIC ORGANOTROPISM [PDF]

, 2016
The solid tumor microenvironment, pre-metastatic niche, and fibrotic environment are known to have significant biochemical and biomechanical similarities to the fibrotic environment. All have significantly increased levels of factors such as TGFβ, HIF1α,
Fletcher, Eliot S, Fletcher, Eliot S
core   +1 more source