Results 91 to 100 of about 29,574 (291)

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Pericytes in Muscular Dystrophies

, 2019
The muscular dystrophies are an heterogeneous group of inherited myopathies characterised by the progressive wasting of skeletal muscle tissue. Pericytes have been shown to make muscle in vitro and to contribute to skeletal muscle regeneration in several animal models, although recent data has shown this to be controversial.
Moyle, Louise Anne, Tedesco, Francesco Saverio, Benedetti, Sara   +2 more
openaire   +4 more sources

Pericyte Bridges in Homeostasis and Hyperglycemia

, 2020
Diabetic retinopathy is a potentially blinding eye disease that threatens the vision of a ninth of diabetic patients. Progression of the disease has long been attributed to an initial dropout of pericytes that enwrap the retinal microvasculature ...
Richard W. Doty (8725973), Ada Admin (8524211), Molly Kelly-Goss (8726025), Paul A. Yates (8726031), Shayn M. Peirce (8131422), Walter L. Murfee (8726026), Bruce A. Corliss (8725967), Natasha Sheybani (8725980), H. Clifton Ray (8725970), Remi Prince (8725988), Gary Owens (1797265), Corbin Mathews (8725977), Kathleen Fitzgerald (8725982), John Chappell (8726028)   +13 more
core   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. [PDF]

, 2013
We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors.
Di Qin (107446), Seungmin Lee (68256), Qin, Di, Christian Kupatt (402864), Rabea Hinkel, Trenkwalder, Teresa, Rabea Hinkel (402865), Deindl, Elisabeth, Chillo, Omary, Teresa Trenkwalder (402861), Seungmin Lee, Christian Kupatt, Omary Chillo, Lee, Seungmin, Omary Chillo (402862), Kupatt, Christian, Elisabeth Deindl (402863), Di Qin, Hinkel, Rabea, Teresa Trenkwalder, Elisabeth Deindl   +20 more
core   +2 more sources

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

The role of pericytes in angiogenesis

The International Journal of Developmental Biology, 2011
Pericytes are branched cells embedded within the basement membrane of capillaries and post-capillary venules. They provide an incomplete investment to endothelial cells, thus reinforcing vascular structure and regulating microvascular blood flow.
RIBATTI D, NICO B, CRIVELLATO, Enrico
openaire   +5 more sources

Phosphoinositide 3-Kinase–Regulated Pericyte Maturation Governs Vascular Remodeling

, 2020
Background: Pericytes regulate vessel stabilization and function, and their loss is associated with diseases such as diabetic retinopathy or cancer. Despite their physiological importance, pericyte function and molecular regulation during angiogenesis ...
Aransay, A.M., Cortazar, A.R., Carracedo, A., Carracedo, Arkaitz, Kobialka, P., Villacampa, Pilar, Cortazar, Ana Rosa, Diéguez-Hurtado, Rodrigo, José Lozano, Juan, Franco, C.A., Graupera, M., Franco, Claudio, Claret, M., Adams, R.H., Figueiredo, A.M., Lozano, J.J., Angulo-Urarte, Ana, Diéguez-Hurtado, R., Graupera, Mariona, Martinez-Romero, A., Claret, Marc, Figueiredo, Ana, Angulo-Urarte, A., Aransay, Ana Maria, Martinez-Romero, Anabel, Kobialka, Piotr, Villacampa, P., Adams, Ralf H.   +27 more
core   +1 more source

Dual role of pericyte α6β1-integrin in tumour blood vessels [PDF]

, 2017
The integrin α6β1 is a major laminin receptor, and formation of a laminin-rich basement membrane is a key feature in tumour blood vessel stabilisation and pericyte recruitment; processes that are important in the growth and maturation of tumour blood ...
Baker, M, Bryan Serrels, Adèle De Arcangelis, Serrels, B, Reynolds, Louise, Louise E. Reynolds, Alexandros Papachristodoulou, Marianne Baker, Reynolds, LE, Arcangelis, Adèle De, Papachristodoulou, Alexandros, Muñoz-Felix, José, Reynolds, Louise E., Serrels, Bryan, Hodivala-Dilke, Kairbaan, Kairbaan M. Hodivala-Dilke, De Arcangelis, Adèle, José M. Muñoz-Félix, D'amico, Gabriela, Papachristodoulou, A, Baker, Marianne, Tanguy Lechertier, Munoz-Felix, JM, D'Amico, G, De Arcangelis, A, Hodivala-Dilke, KM, Muñoz-félix, José M., Gabriela D'Amico, Hodivala-dilke, Kairbaan M., Lechertier, Tanguy, Lechertier, T   +30 more
core   +1 more source