Results 91 to 100 of about 27,494 (299)

Phosphoinositide 3-Kinase–Regulated Pericyte Maturation Governs Vascular Remodeling

, 2020
Background: Pericytes regulate vessel stabilization and function, and their loss is associated with diseases such as diabetic retinopathy or cancer. Despite their physiological importance, pericyte function and molecular regulation during angiogenesis ...
Aransay, A.M., Cortazar, A.R., Carracedo, A., Carracedo, Arkaitz, Kobialka, P., Villacampa, Pilar, Cortazar, Ana Rosa, Diéguez-Hurtado, Rodrigo, José Lozano, Juan, Franco, C.A., Graupera, M., Franco, Claudio, Claret, M., Adams, R.H., Figueiredo, A.M., Lozano, J.J., Angulo-Urarte, Ana, Diéguez-Hurtado, R., Graupera, Mariona, Martinez-Romero, A., Claret, Marc, Figueiredo, Ana, Angulo-Urarte, A., Aransay, Ana Maria, Martinez-Romero, Anabel, Kobialka, Piotr, Villacampa, P., Adams, Ralf H.   +27 more
core   +1 more source

Current Perspective on the Location and Function of Gamma- Aminobutyric Acid (GABA) and its Metabolic Partners in the Kidney. [PDF]

, 2014
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter located in the mammalian central nervous system, which binds to GABAA and GABAB receptors to mediate its neurological effects.
Peppiatt-Wildman, Claire M., Wildman, Scott S.P., Dunn, Kadeshia, Kelley, Stephen P., Wildman, Scott S. P.   +4 more
core   +1 more source

Pericyte contractility, microvascular blood flow and the consequences of stroke

, 2023
Scope and AimsSeveral common diseases, including ischemic stroke, display pathological changes in cerebral blood flow. Recent advances in imaging have revealed that blood flow regulation in the brain begins at the capillary level, not the arteriole level.
Lachlan Brown (14732626)
core   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

Advanced Science
Pericytes exhibits distinct morphological features on microvessels during various stages of brain‐blood barrier (BBB) development and neurological disorders. However, the underlying mechanisms by which pericyte morphology influences BBB integrity are not
Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, Yue Dai, Zhao‐You Meng, Chen‐Hao Zhao, Bao‐Liang Sun, Qi Xie, Fang‐Fei Li, Qing‐Wu Yang   +16 more
doaj   +1 more source

An investigation into murine pericyte shape change in response to inflammatory stimuli in vitro and in vivo

, 2011
PhDLeukocyte transmigration through venular walls into the surrounding tissue is a crucial event during inflammatory responses. Despite increased understanding of the mechanisms associated with leukocyte migration through endothelial cells, little is ...
Proebstl, Doris
core  

Pericyte-Derived MFG-E8 Regulates Pathologic Angiogenesis

, 2011
Objective— MFG-E8 (also called lactadherin and SED1) is a secreted glycoprotein that has been previously implicated in enhancement of vascular endothelial growth factor–dependent angiogenesis.
Yayoi Tada, Triantafyllos Chavakis, Mark C. Udey, Sei-ichiro Motegi, Michael Lu, Miklós Sárdy, Chuanjin Wu, Wolfgang W. Leitner   +7 more
core   +1 more source

Pericyte-Endothelial Interactions in the Retinal Microvasculature

, 2020
Retinal microvasculature is crucial for the visual function of the neural retina. Pericytes and endothelial cells (ECs) are the two main cellular constituents in the retinal microvessels. Formation, maturation, and stabilization of the micro-vasculatures
Hu Huang
core   +1 more source

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

Pericyte signaling via soluble guanylate cyclase shapes the vascular niche and microenvironment of tumors

The EMBO Journal
Pericytes and endothelial cells (ECs) constitute the fundamental components of blood vessels. While the role of ECs in tumor angiogenesis and the tumor microenvironment is well appreciated, pericyte function in tumors remains underexplored. In this study,
Jing Zhu, Wu Yang, Jianyun Ma, Hao He, Zhen Liu, Xiaolan Zhu, Xueyang He, Jing He, Zhan Chen, Xiaoliang Jin, Xiaohong Wang, Kaiwen He, Wu Wei, Junhao Hu   +13 more
doaj   +1 more source