Proposal of a Theoretically Feasible Method to Perform Perilymph Sampling in Clinical Settings [PDF]
LifeThe ability to analyze perilymph could allow inner ear pathologies to be studied. However, today, perilymph sampling is only performed for research purposes because of the risk of negative outcomes such as hearing loss or balance disorders.
Federico Maria Gioacchini +8 more
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The missing perilymph sign on MRI indicates a perilymphatic fistula: A case report [PDF]
Journal of OtologyA perilymphatic fistula (PLF) is a rare condition in which perilymph leaks from the cochlea or vestibule into the surrounding cavities, most commonly through round and oval windows, and causes cochlear and vestibular symptoms. However, vague symptoms and
Jing Zou, Hongbi Li
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Secretion of cochlin-tomoprotein (LCCL) in the middle ear following acute tympanic injury: implications for perilymph fistula diagnosis [PDF]
Frontiers in NeurologyIntroductionCochlin is the most abundant protein in the inner ear. The cleaved N-terminal domain of cochlin, known as LCCL and referred to as CTP (cochlin tomoprotein) in clinical biomarker usage, is a perilymph-specific protein and is widely used as a ...
Seong Hoon Bae +12 more
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MRI-based measurement of inner ear fluids reveals increased endolymph volume variability in patients with endolymphatic hydrops and hearing instability [PDF]
Scientific ReportsLack of proven biomarkers for hearing instability (HI) disorders leads to difficulty and delays in diagnosis. Given the association of HI with endolymphatic hydrops (EH), imaging-based techniques for quantification of endolymph and perilymph may be ...
Julia Telischi +8 more
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Drug selection for inner ear therapy [PDF]
Frontiers in PharmacologyIntroductionOne of the primary tenets in pharmacotherapy is that the applied drug must reach the target tissue at therapeutic concentration. For many therapies intended to treat hearing disorders it has become apparent that we have failed to achieve this
Alec N. Salt, Jeremy G. Turner
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Protein profile of mouse endolymph suggests a role in controlling cochlear homeostasis [PDF]
iScienceSummary: The cochlea contains two extracellular fluids, perilymph and endolymph. Endolymph exhibits high potential of approximately +80 to +110 mV (depending on species), which sensitizes sensory hair cells.
Masatoshi Fukuda +11 more
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Semicircular canal drug delivery safely targets the inner ear perilymphatic space [PDF]
JCI InsightEffective, reproducible, and safe delivery of therapeutics into the inner ear is required for the prevention and treatment of hearing loss. A commonly used delivery method is via the posterior semicircular canal (PSCC); however, its specific targeting ...
Jinkyung Kim +6 more
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Distinct MicroRNA Profiles in the Perilymph and Serum of Patients With Menière's Disease
Frontiers in Neurology, 2021 Hypothesis: Menière's disease microRNA (miRNA) profiles are unique and are reflected in the perilymph and serum of patients.Background: Development of effective biomarkers for Menière's disease are needed. miRNAs are small RNA sequences that downregulate
Matthew Shew +4 more
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PLoS ONE, 2022 Modern proteomic analysis and reliable surgical access to gain liquid inner ear biopsies have enabled in depth molecular characterization of the cochlea microenvironment.
Martin Durisin +8 more
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Significance of Pseudo-Conductive Hearing Loss and Positional Nystagmus for Perilymphatic Fistula: Are They Related to Third-Window Effects? [PDF]
Clinical and Experimental Otorhinolaryngology, 2021 Objectives Patients’ clinical presentation is critical for identifying suspected perilymphatic fistula (PLF). The involvement of third-window lesions in the pathomechanism of PLF has been hypothesized. This study investigated the clinical features of PLF
Jong Sei Kim +4 more
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