Results 21 to 30 of about 4,318 (158)
Pharmacokinetics of sodium thiosulfate in Guinea pig perilymph following middle ear application
Journal of Otology, 2018 Hypothesis: To determine the pharmacokinetics of sodium thiosulfate in the inner ear perilymph following middle ear application in Guinea pigs. Background: Cisplatin chemotherapy is often associated with a dose-dependent high frequency sensorineural ...
Ronald J. Schroeder, II +3 more
doaj +1 more source
Detection of BDNF-Related Proteins in Human Perilymph in Patients With Hearing Loss
Frontiers in Neuroscience, 2019 The outcome of cochlear implantation depends on multiple variables including the underlying health of the cochlea. Brain derived neurotrophic factor (BDNF) has been shown to support spiral ganglion neurons and to improve implant function in animal models.
Ines de Vries +10 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Until recently, the most standard treatment for sensorineural or sudden hearing loss, which is caused by inner ear damage or deterioration, has been systemic oral steroid administration.
Jin Woo Jung +8 more
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Frontiers in Cellular Neuroscience, 2019 Some forms of triamcinolone may provide alternate options for local therapy of the inner ear in addition to the steroids currently in use. We compared the perilymph pharmacokinetics of triamcinolone-acetonide, triamcinolone, and dexamethasone, each ...
Alec Nicholas Salt +3 more
doaj +1 more source
Metabolomic Studies in Inner Ear Pathologies
Metabolites, 2022 Sensorineural hearing loss is the most common sensory deficit. The etiologies of sensorineural hearing loss have been described and can be congenital or acquired.
Luc Boullaud +3 more
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Proteome of Human Perilymph [PDF]
Journal of Proteome Research, 2011 Current diagnostic tools limit a clinician's ability to discriminate between many possible causes of sensorineural hearing loss. This constraint leads to the frequent diagnosis of the idiopathic condition, leaving patients without a clear prognosis and only general treatment options.
Andrew C, Lysaght +5 more
openaire +2 more sources
Metabolites, 2019 Perilymph metabolomic analysis is an emerging innovative strategy to improve our knowledge of physiopathology in sensorineural hearing loss. This study aims to develop a metabolomic profile of human perilymph with which to evaluate the relationship ...
Thuy-Trân Trinh +6 more
doaj +1 more source
Journal of Otology, 2020 Objectives: To evaluate the pathological changes in the blood-perilymph, blood-endolymph, and blood-nerve barriers of a patient with idiopathic sudden sensorineural hearing loss (SSNHL).
Jing Zou
doaj +1 more source
Brazilian Journal of Otorhinolaryngology, 2010 As fístulas perilinfáticas ainda constituem um grande desafio quanto ao seu tratamento. Em alguns casos, seu fechamento cirúrgico pode reduzir as sequelas auditivas e vestibulares.
Ektor Tsuneo Onishi, Yotaka Fukuda
doaj +1 more source
The diagnostic performance of a novel ELISA for human CTP (Cochlin-tomoprotein) to detect perilymph leakage. [PDF]
PLoS ONE, 2018 Perilymphatic fistula is defined as an abnormal communication between the perilymph-filled space and the middle ear, or cranial spaces. The manifestations include a broad spectrum of neuro-otological symptoms such as hearing loss, vertigo/dizziness ...
Tetsuo Ikezono +16 more
doaj +1 more source