Results 11 to 20 of about 10,309 (205)

Linking FHIR-Based Medication Data to a Computable Algorithm for Heart Medication Optimization: A Critical Component of Any Medication Learning Health System. [PDF]

Learn Health Syst
ABSTRACT Introduction Despite strong evidence supporting guideline‐directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF), a significant gap persists in the consistent application of these therapies. This shortfall has prompted organizations like the American College of Cardiology to recommend leveraging electronic ...
LeGrand J, Ali MS, Flynn A, Arzac J, Lester C, Dorsch MP.   +5 more
europepmc   +2 more sources

Practical use of single pill combinations in the treatment of hypertension — an analysis focused on perindopril-based combinations

Arterial Hypertension, 2023
Hypertension (HTN) is a major modifiable cardiovascular risk factor. Despite availability of effective blood pressure-lowering medications, HTN remains poorly controlled.
Aleksander Prejbisz, Piotr Dobrowolski, Adrian Doroszko, Krzysztof J. Filipiak, Andrzej Januszewicz, Agnieszka Olszanecka, Krzysztof Narkiewicz, Andrzej Tykarski, Jacek Wolf   +8 more
doaj   +1 more source

Zero crossing and ratio spectra derivative spectrophotometry for the dissolution tests of amlodipine and perindopril in their fixed dose formulations

Current Issues in Pharmacy and Medical Sciences, 2014
Dissolution tests of amlodipine and perindopril from their fixed dose formulations were performed in 900 mL of phosphate buffer of pH 5.5 at 37°C using the paddle apparatus.
Maczka Paulina, Gumieniczek Anna, Galeza Justyna, Pietras Rafal   +3 more
doaj   +1 more source

Simultaneous determination of indapamide, perindopril and perindoprilat in human plasma or whole blood by UPLC-MS/MS and its pharmacokinetic application

Journal of Pharmaceutical Analysis, 2018
Simple and sensitive methods were developed for the determination of indapamide, perindopril and its active metabolite perindoprilat in human plasma or whole blood by hyphenated ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS ...
Yi Tao, Sheng Wang, Lei Wang, Min Song, Taijun Hang   +4 more
doaj   +1 more source

Potential pharmacokinetic interactions in fixed-dose combinations of perindopril/indapamide/amlodipine compared with perindopril/indapamide and amlodipine in healthy Chinese volunteers

Acta Materia Medica, 2023
S05590 is a fixed-dose combination of perindopril tert-butylamine 4 mg/indapamide 1.25 mg, and S06593 is a fixed-dose combination of perindopril arginine 5 mg/indapamide 1.25 mg/amlodipine 5 mg.
Huitao Gao, Hongzhong Liu, Xin Zheng, Xinge Cui, Stephanie Bricout-Hennel, Arnaud Lucien, Pauline Lauruol, Yaqin Wang, Xue Wang, Hongyun Wang, Chen Rui   +10 more
doaj   +1 more source

Method development and validation of HPLC tandem/mass spectrometry for quantification of perindopril arginine and amlodipine besylate combination in bulk and pharmaceutical formulations

Research in Pharmaceutical Sciences, 2017
A well-characterized and fully validated ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometric (UHPLC-ESI-MS/MS) method was developed to reliably analyze combination of perindopril arginine and amlodipine besylate
Kalaiyarasi Duraisamy, K S Jaganathan, Marothu Vamsi krishna   +2 more
doaj   +1 more source

Modulatory effects of perindopril on cisplatin-induced nephrotoxicity in mice: Implication of inflammatory cytokines and caspase-3 mediated apoptosis

Acta Pharmaceutica, 2020
Cisplatin-induced nephrotoxicity limits its anticancer effectiveness, thus this study’s aim was to assess the potential modulatory effect of perindopril on cisplatin-induced nephrotoxicity and to elucidate the possible underlying mechanisms.
Aljuhani Naif, Ismail Raed S., El-Awady Mohammed S., Hassan Memy H.   +3 more
doaj   +1 more source

Locally administrated perindopril improves healing in an ovariectomized rat tibial osteotomy model. [PDF]

PLoS ONE, 2012
Angiotensin-converting enzyme inhibitors are widely prescribed to regulate blood pressure. High doses of orally administered perindopril have previously been shown to improve fracture healing in a mouse femur fracture model.
Xiong Zhao, Zi-xiang Wu, Yang Zhang, Ming-xuan Gao, Ya-bo Yan, Peng-chong Cao, Yuan Zang, Wei Lei   +7 more
doaj   +1 more source

Modern Recommendations and Real Clinical Practice: the Results of the SILA Study

Рациональная фармакотерапия в кардиологии, 2019
Aim. To assess efficacy and safety of single-pill combination (SPC) amlodipine/perindopril and amlodipine/indapamide/perindopril in patients with uncontrolled hypertension (HT) in routine clinical practice.Material and methods.
O. A. Kislyak, I. I. Chukaeva, V. A. Vygodin   +2 more
doaj   +1 more source

Possible combined effect of perindopril and Azilsartan in an experimental model of dementia in rats

Saudi Pharmaceutical Journal, 2020
Renin-angiotensin system exerted deleterious effects on learning and cognitive functions through different mechanisms. The present study has been designed to evaluate the protective effect of perindopril and azilsartan as monotherapy or in combination on
Yahya M. Alzahrani, Mai A. Alim A. Sattar, Fatemah O. Kamel, Wafaa S. Ramadan, Yahya A. Alzahrani   +4 more
doaj   +1 more source