Results 41 to 50 of about 30,130 (194)

Craniofacial Resection for Advanced Cutaneous Squamous Cell Carcinoma: Results From the 2nd International Collaborative Case‐Series

Head &Neck, EarlyView.
ABSTRACT Background Robust outcome data for anterior skull base cutaneous squamous cell carcinoma (cSCC) are limited, particularly as emerging therapies reshape management. We evaluated survival and prognostic factors following craniofacial resection. Methods Retrospective multi‐institutional case‐series (1995–2015) of patients who underwent skull base
Michael J. C. Schachtel, Benedict J. Panizza, James J. Bowman, Catherine Barnett, Cristina Valero, Ian Ganly, Snehal G. Patel, Helena Levyn, Dauren Adilbay, Alana Eagan, Marc A. Cohen, Lillian A. Boe, Junting Zheng, Mithat Gonen, Prathamesh Pai, Paolo Castelnuovo, Fang Ju Gao, Cesare Piazza, Piero Nicolai, Luiz P. Kowalski, Ronaldo N. Toledo, Claudio Cernea, Sergio Goncalves, Dan M. Fliss, John R. de Almeida, Ian Witterick, Philippe Herman, Walter Fontanella, Gregorio Sanchez Aniceto, Alvaro Rivero Calle, Sefik Hosal, Serdar Ozer, Subramania Iyer, Richard J. Harvey, C. Rene Leemans, Jan‐Jaap Hendrickx, Marcelo Figari, Luis Boccalatte, Ken Ichi Nibu, Peter Clarke, Catherine Rennie, Yiming Zhu, Rodney J. Schlosser, Fernando L. Dias, Zoukaa Sargi, Shahzada Ahmed, Wojciech Golusinski, Se Heon Kim, Shirley Y. Su, Shaan M. Raza, Franco DeMonte, Ehab Hanna, Jatin P. Shah   +52 more
wiley   +1 more source

Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Glossotonsillar Sulcus Involvement Conveys an Unfavorable Oncological Outcome

Head &Neck, EarlyView.
ABSTRACT Background Transoral robotic surgery (TORS) is widely used in management of early‐stage primary oropharyngeal squamous cell carcinoma (OPSCC). Tumors involving the glossotonsillar sulcus (GTS) are hypothesized to confer worse oncological outcomes compared to those situated in the rest of the oropharynx, with a paucity of evidence to support ...
Johan S. Nilsson, John C. Hardman, James Tsimiklis, Bora Jeong, Maryam Khan, Jonathan Daniel, Giri Krishnan, Andrew Foreman, Suren Krishnan, John‐Charles Hodge   +9 more
wiley   +1 more source

Characterization of Perineural Invasion Parameters for Risk Stratification in Oral Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Perineural invasion (PNI) is an established adverse prognostic factor in oral squamous cell carcinoma (OSCC), but the implications of its extent as well as its relationship with surgical margin status and the extent of microscopic tumor spread remain unclear.
Michael A. Müller, Muriel D. Brada, Niels J. Rupp, Cosima E. Riemenschnitter, Simon Müller, Alexander M. Huber, Panagiotis Balermpas, Grégoire B. Morand   +7 more
wiley   +1 more source

M3 muscarinic acetylcholine receptors regulate epithelial–mesenchymal transition, perineural invasion, and migration/metastasis in cholangiocarcinoma through the AKT pathway

Cancer Cell International, 2018
Background Cholangiocarcinoma is a highly malignant tumor type that is not sensitive to radiotherapy or chemotherapy due to aggressive perineural invasion and metastasis.
Yujie Feng, Xiao Hu, Guangwei Liu, Lianfang Lu, Wei Zhao, Fangzhen Shen, Kai Ma, Chuandong Sun, Chengzhan Zhu, Bingyuan Zhang   +9 more
doaj   +1 more source

MAGE-A3 is a prognostic biomarker for poor clinical outcome in cutaneous squamous cell carcinoma with perineural invasion via modulation of cell proliferation.

PLoS ONE, 2020
Perineural invasion is a pathologic process of neoplastic dissemination along and invading into the nerves. Perineural invasion is associated with aggressive disease and a greater likelihood of poor outcomes. In this study, 3 of 9 patients with cutaneous
Aaron Chen, Alexis L Santana, Nicole Doudican, Nazanin Roudiani, Kristian Laursen, Jean-Philippe Therrien, James Lee, Diane Felsen, John A Carucci   +8 more
doaj   +1 more source

Prognostic Impact of Lymphovascular Invasion on Distant Metastasis in HPV‐Negative Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Lymphovascular invasion (LVI) is a recognized poor prognostic factor in head and neck squamous cell carcinoma (HNSCC), particularly for regional recurrence and overall survival. However, its role in predicting distant metastasis, especially in HPV‐negative HNSCC, remains unclear. Objective To evaluate the association between LVI and
Mark Khoury, Alex Mlynarek, Keith Richardson, Nader Sadeghi, Michael Hier, Christina Tsien, George Shenouda, Khalil Sultanem, Nathaniel Bouganim, Khashayar Esfahani, Sabrina Wurzba, Marco Mascarella   +11 more
wiley   +1 more source

Pretreatment Cachexia Index Is Associated With Severe Treatment Toxicity and Overall Survival in HPV‐Negative Head and Neck Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Introduction Cancer cachexia is characterized by skeletal muscle loss, poor nutrition, and systemic inflammation and is common in head and neck cancer. We evaluated whether the Cachexia Index (CXI) predicts treatment toxicity and survival in HPV‐negative HNSCC.
Gianluca Savoia, Michael P. Hier, Nader Sadeghi, Alex Mlynarek, Keith Richardson, Sabrina Daniela Silva Wurzba, Christina Tsien, George Shenouda, Khalil Sultanem, Nathaniel Bouganim, Khashayar Esfahani, Marco A. Mascarella   +11 more
wiley   +1 more source

Evaluation of the details and importance of lymphatic, microvascular, and perineural invasion in patients with non-functioning pancreatic neuroendocrine neoplasms based on tumor size and the 2022 World Health Organization classification: a 23-year retrospective analysis

World Journal of Surgical Oncology
Background Although, recently observation methods has been proposed as one of the treatment options for non-functioning pancreatic neuroendocrine neoplasms (NF-PanNENs), determining treatment strategies may be difficult for small and low-malignant NF ...
Wataru Izumo, Hiromichi Kawaida, Ryo Saito, Yuki Nakata, Hidetake Amemiya, Suguru Maruyama, Koichi Takiguchi, Katsutoshi Shoda, Kensuke Shiraishi, Shinji Furuya, Yoshihiko Kawaguchi, Kunio Mochizuki, Tetsuo Kondo, Daisuke Ichikawa   +13 more
doaj   +1 more source

The Relationship between Perineural Invasion, Peritumoural Inflammation, and Cervical Lymph Node Metastases in Laryngeal Squamous Cell Carcinoma [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Amongst all the malignant tumours, laryngeal cancer is found in 2.2% of males and 0.4% of females. Histopathologically, 90-95% of all laryngeal cancer is Squamous Cell Carcinoma (SCC). Tumour stage and cervical lymph node metastases are the
Mecdi Gurhan Balci, Mahir Tayfur, Tülay Basak   +2 more
doaj   +1 more source

Adjuvant Chemotherapy Regimens in Resected Biliary Tract Cancers: National, Comparative, Observational Study (TOG/GI‐SAFRADJU‐2501)

International Journal of Cancer, EarlyView.
ABSTRACT The recommended adjuvant chemotherapy (adj‐ChT) regimen for resected biliary tract cancers (BTC) is capecitabine (Cape); yet, the recommendation is based on limited evidence. Although varied adj‐ChTs have been employed in practice, robust real‐world data is scarce. We conducted a national, multicenter, hospital‐based registry study to evaluate
Erman Akkus, Mehmet Kayaalp, Müzeyyen Aslı Ergözoğlu, Ilgın Koç Kuş, Doğan Bayram, Bilgeşah Kılıçtaş, Emel Ayvaz Güneyin, Ali Kalem, Haydar Temizyürek, Mehmet Mutlu Çatlı, Mehmet Sinan Akarca, Maral Martin Mıldanoğlu, Görkem Turhan, Mahmut Kara, Hacı Arak, Feyza Arslan Tan, Burak Paçacı, Berkay Yeşilyurt, Orhun Akdoğan, Emine Bihter Çetin, Selahattin Çelik, Fatma Keskin Uzundere, Elif Şahin, Zehra Sadak Öcal, Lamia Şeker Can, Bahadır Köylü, Mehmet Cem Fidan, Esmanur Kaplan Tüzün, Teoman Şakalar, Elif Sertesen Çamöz, Haydar Çağatay Yüksel, Onur Yazdan Balçık, Pınar Peker, Mehmet Yılmaz, Şeymanur Ala Enli, Erdem Kölemen, Sibel Oyucu Orhan, Yakup Düzköprü, Mustafa Ersoy, Tuğba Akın Telli, Mesut Yılmaz, Yusuf İlhan, Atila Yıldırım, Ramazan Coşar, Müslih Ürün, Arif Hakan Önder, Murat Araz, Ertuğrul Bayram, Havva Yeşil Çınkır, Ali Alkan, Mustafa Gürbüz, Nilüfer Avcı, Fatma Paksoy Türköz, İsmail Oğuz Kara, Fatih Köse, İlkay Tuğba Ünek, Ahmet Bilici, Öznur Bal, Şuayib Yalçın, Lorenza Rimassa, Hatime Arzu Yaşar   +60 more
wiley   +1 more source