Results 51 to 60 of about 30,130 (194)

Improved Prediction of Colon Cancer Recurrence Using the ColoNode mRNA Test: A 5‐Year Survival Analysis

International Journal of Cancer, EarlyView.
ABSTRACT Twenty‐five percent of colon cancer patients having curative surgery will recur. Most of them will die from distant metastasis partly due to shortcomings of routine histopathological analysis, that is, undetected tumor cells in the regional lymph node field.
Basel Sitohy, Gudrun Lindmark, Anne Israelsson, Lina Olsson, Tamer Roshdy, Joel Blomqvist, Sara Kero, Mattias Söderholm, Annamaria Turi, Thorbjörn Sakari, Michiel Dooper, George Dafnis, Pehr Forsberg, Susanne Skovsted, Maria Walldén, Chih‐Han Kung, Martin Rutegård, Johanna Nordmyr, Måns Muhrbeck, Sten Hammarström, Marie‐Louise Hammarström   +20 more
wiley   +1 more source

Pancreatic cancer cells infiltrate nerves through TGFbeta1-driven perineural epithelial-to-mesenchymal-like transdifferentiation

Neoplasia: An International Journal for Oncology Research
Neural invasion is a prognostic hallmark of pancreatic ductal adenocarcinoma (PDAC), yet the underlying mechanisms behind the disruption of perineural barriers and access of cancer cells into intrapancreatic nerves remain poorly understood.
Theresa Krauss, Ibrahim Halil Gürcinar, Ulrike Bourquain, Maren Hieber, Evelyn N. Krohmer, Nan Wu, Sergey Tokalov, Rüdiger Goess, Carmen Mota Reyes, Dieter Saur, Helmut Friess, Güralp O. Ceyhan, Ihsan Ekin Demir, Okan Safak   +13 more
doaj   +1 more source

Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma

Biomedical Papers, 2019
Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. Several biological and molecular criteria have been established for making a prognosis of OSCC.
Jaroslav Michalek, Svetlana Brychtova, Richard Pink, Zdenek Dvorak   +3 more
doaj   +1 more source

Lymphovascular space involvement as a prognostic factor for survival outcomes in vulvar cancer: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Lymphovascular space involvement (LVSI) is a significant prognostic factor of survival outcomes in gynecologic oncology. Synthetic studies on vulvar cancer are lacking as well as clear consensus about the importance of LSVI in vulvar cancer.
Vasilios Pergialiotis, Maria Fanaki, Michail Panagiotopoulos, Vasilios Lygizos, Dimitrios Efthimios Vlachos, Nikolaos Thomakos, Dimitrios Haidopoulos   +6 more
wiley   +1 more source

Tissue Clearing for Lymph Nodes: 3D Mapping of Nerves and the Immune Microenvironment

iNew Medicine, EarlyView.
ABSTRACT Lymph nodes (LNs) are central hubs of adaptive immunity and key relay sites for metastatic tumour cells. However, conventional two‐dimensional histology samples only a small fraction of each node, potentially missing micrometastases and multifocal involvement while obscuring long‐range spatial relationships among tumour deposits, immune ...
Guang‐Hong Su, Fei Wang, Ting‐Hong Wei, Rui Lu, Wen‐Jun Huang, Xiang Zhang, Ling Yin, Jun Li   +7 more
wiley   +1 more source

Perioperative Risks of Concurrent Pancreatic and Hepatic Resections for Neuroendocrine Tumors

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Pancreatic neuroendocrine tumors (pNETs) account for 1%–2% of pancreatic tumors, with an increasing incidence. The safety of concurrent pancreas‐liver resections remains uncertain. This study evaluated the national outcomes of concurrent pancreatectomy and liver‐directed surgery for pNETs. Methods ACS‐NSQIP (2019–2023)
Amir Ebadinejad, Ashrita Raghuram, Sophia Xiao, Ethan Angle, Hassan Aziz   +4 more
wiley   +1 more source

Prognostic Determinants of Overall Survival After Resection for Pancreatic Ductal Adenocarcinoma: A Consensus‐Based Conceptual Framework

Journal of Surgical Oncology, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis despite surgical resection, yet the prognostic literature remains fragmented across hundreds of single‐institution studies that vary in design, covariates, and analytical approaches.
Muhammad Maisam Ali, Kaleem S. Ahmed, Clayton T. Marcinak, Syed Ali Tayyeb Hasan, Anne D. Letocha, Noorain Ahmad, Haider bin Khalid, Kainat Fatima, Syed Nabeel Zafar   +8 more
wiley   +1 more source

Factors Associated With Receipt of Adjuvant Radiation in Locally Advanced Rectal Cancer

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Neoadjuvant radiotherapy (RT) has been the standard of care for locally advanced rectal cancer (LARC) for over two decades. Adjuvant RT use in LARC represents a deviation from standard care and warrants further investigation. Objectives To identify factors associated with adjuvant RT utilization.
Maryam Sherwani, Danish Ali, Hanjoo Lee, Alexander T. Hawkins, Aimal Khan   +4 more
wiley   +1 more source

Pattern of HER2 and HER3 Overexpression in Patients with Pancreatic Ductal Adenocarcinoma

Medicina
Background and Objectives: Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive, heterogeneous, and lethal human malignancies, underscoring the urgent need for novel, targeted therapeutic strategies for neo(adjuvant) individualized ...
Ioan Cătălin Bodea, Andra Ciocan, Florin Vasile Zaharie, Raluca Bodea, Ștefan Ursu, Răzvan Alexandru Ciocan, Răzvan George Bogdan, Alin Fetti, Sorana D. Bolboacă, Filip Cristian Tocoian, Bobe Petrushev, Ana Maria Fit, Ioana Rusu, Roxana Liana Popa, Nadim Al Hajjar   +14 more
doaj   +1 more source

Reflectance Confocal Microscopy Features of Nevoid Melanoma: Case Report and Literature Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Nevoid melanoma (NM) is a rare melanoma variant that often mimics benign compound or intradermal nevi, both clinically and histopathologically. Due to its deceptively benign appearance, diagnosis is frequently delayed, resulting in advanced Breslow thickness at presentation.
Umberto Santaniello, Paolo Fava, Martina Mangeruga, Rebecca Senetta, Pietro Quaglino, Simone Ribero, Francesco Cavallo   +6 more
wiley   +1 more source