Results 151 to 160 of about 134,149 (194)
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Perineuronal nets in the auditory system
Hearing Research, 2015Perineuronal nets (PNs) are a unique and complex meshwork of specific extracellular matrix molecules that ensheath a subset of neurons in many regions of the central nervous system (CNS). PNs appear late in development and are supposed to restrict synaptic plasticity and to stabilize functional neuronal connections.
Mandy, Sonntag +4 more
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Neurocan Contributes to Perineuronal Net Development
Neuroscience, 2020Perineuronal nets (PNs) are matrix molecule assemblies surrounding neuronal somata, dendrites and axon initial segments in a lattice-like appearance. PN molecules are involved in many structural and physiological processes during development and in adulthood, suggesting a crucial role in normal brain function.
Sophie, Schmidt +3 more
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Perineuronal nets’ role in metabolism
American Journal of Physiology - Endocrinology and MetabolismPerineuronal nets (PNNs), specialized extracellular matrix (ECM) structures that envelop neurons, have recently been recognized as key players in the regulation of metabolism. This review explores the growing body of knowledge concerning PNNs and their role in metabolic control, drawing insights from recent research and relevant studies.
Nan Zhang, Tianshu Zeng
exaly +3 more sources
Perineuronal nets: past and present
Trends in Neurosciences, 1998Golgi ranked the peripheral reticulum--which adheres intimately to nerve cell surfaces--alongside the intracellular reticulum, or Golgi apparatus,which immortalized his name. At first dismissed as an artefact of capricious staining techniques, this peripheral reticulum, or perineuronal net, is now recognized as a genuine entity in neurocytology.
Celio MR +3 more
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Perineuronal Nets: Role in Normal Brain Physiology and Aging, and Pathology of various Diseases.
Ageing Research ReviewsPerineuronal nets (PNNs) are a specialized extracellular matrix in the central nervous system. They are widely distributed in the brain, with distribution patterns varying by brain region.
Kaiqi Zhu +4 more
semanticscholar +1 more source
The two faces of perineuronal nets
NeuroReport, 2000Perineuronal nets are extracellular structures enwrapping the soma and proximal dendrites of some neurons known to be parvalbumin immunoreactive. The composition of the nets is not completely known, but it can change between different neurons. We studied the heterogeneous composition of a specific component of perineuronal nets, the signaling molecule ...
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Perineuronal Nets: Subtle Structures with Large Implications
The Neuroscientist, 2022Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround the soma and proximal dendrites of certain neurons in the central nervous system, particularly parvalbumin-expressing interneurons. Their appearance overlaps the maturation of neuronal circuits and the closure of critical periods in different regions of the ...
Héctor Carceller +3 more
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The perineuronal net and the control of CNS plasticity
Cell and Tissue Research, 2012Perineuronal nets (PNNs) are reticular structures that surround the cell body of many neurones, and extend along their dendrites. They are considered to be a specialized extracellular matrix in the central nervous system (CNS). PNN formation is first detected relatively late in development, as the mature synaptic circuitry of the CNS is established and
Difei, Wang, James, Fawcett
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Neuropharmacology
Neuropathic pain (NP), resulting from nerve damage or diseases, significantly impacts patients' quality of life. Bioinformatics analysis can assist researchers in identifying key molecular pathways involved disease progression.
Jiahui Pang +9 more
semanticscholar +1 more source
Neuropathic pain (NP), resulting from nerve damage or diseases, significantly impacts patients' quality of life. Bioinformatics analysis can assist researchers in identifying key molecular pathways involved disease progression.
Jiahui Pang +9 more
semanticscholar +1 more source
Brain Research
Cannabidiol (CBD) has shown potential for treating schizophrenia (SCZ) by targeting its positive and negative cognitive symptoms. In this study, we investigated if CBD could reverse the memory impairment observed after chronic administration of the NMDA ...
N. Rodrigues da Silva +6 more
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Cannabidiol (CBD) has shown potential for treating schizophrenia (SCZ) by targeting its positive and negative cognitive symptoms. In this study, we investigated if CBD could reverse the memory impairment observed after chronic administration of the NMDA ...
N. Rodrigues da Silva +6 more
semanticscholar +1 more source