Results 1 to 10 of about 2,231 (191)
The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders [PDF]
Frontiers in Molecular Neuroscience, 2018 Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that PV cells and PNN are impaired in a variety of neurological disorders.
Teresa H. Wen +6 more
doaj +7 more sources
Caught in the Net: Perineuronal Nets and Addiction [PDF]
Neural Plasticity, 2016 Exposure to drugs of abuse induces plasticity in the brain and creates persistent drug-related memories. These changes in plasticity and persistent drug memories are believed to produce aberrant motivation and reinforcement contributing to addiction ...
Megan Slaker +2 more
doaj +5 more sources
Running-induced neurogenesis reduces CA1 perineuronal net density without substantial temporal delay [PDF]
Molecular BrainAerobic exercise has many effects on brain function, particularly at the hippocampus. Exercise has been shown to increase the rate of adult neurogenesis within the dentate gyrus and decrease the density of perineuronal nets in area CA1.
Dylan J. Terstege +3 more
doaj +3 more sources
Update on Perineuronal Net Staining With Wisteria floribunda Agglutinin (WFA) [PDF]
Frontiers in Integrative Neuroscience, 2022 As chemically specialized forms of the extracellular matrix in the central nervous system, polyanionic perineuronal nets (PNs) contain diverse constituents, including chondroitin sulfate proteoglycans (CSPGs), hyaluronic acid, and tenascins.
Wolfgang Härtig +5 more
doaj +4 more sources
Perineuronal Net Receptor PTPσ Regulates Retention of Memories [PDF]
Frontiers in Synaptic Neuroscience, 2021 Perineuronal nets (PNNs) have an important physiological role in the retention of learning by restricting cognitive flexibility. Their deposition peaks after developmental periods of intensive learning, usually in late childhood, and they help in long ...
Angelina Lesnikova +5 more
doaj +4 more sources
Minimally invasive protocols and quantification for microglia-mediated perineuronal net disassembly in mouse brain [PDF]
STAR Protocols, 2021 Summary: Enzymatic digestion of the extracellular matrix with chondroitinase-ABC reinstates juvenile-like plasticity in the adult cortex as it also disassembles the perineuronal nets (PNNs).
Alessandro Venturino, Sandra Siegert
doaj +4 more sources
Cell Reports, 2021 Summary: The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the complex homeostatic feedback responses required for the maintenance of energy balance.
Sara Kohnke +21 more
doaj +4 more sources
Perineuronal Net Dynamics in the Pathophysiology of Epilepsy [PDF]
Epilepsy Currents, 2021 Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap around GABAergic parvalbumin (PV) interneurons. During development, PNN formation terminates the critical period of neuroplasticity, a process that can be reversed by experimental ...
Lata Chaunsali +2 more
exaly +6 more sources
Neonatal Zika virus infection causes transient perineuronal net degradation [PDF]
Frontiers in Cellular Neuroscience, 2023 Perineuronal nets (PNNs) form a specialized extracellular matrix that predominantly surrounds parvalbumin (PV)-expressing GABAergic inhibitory interneurons and help regulate neuronal activity. Their formation early in the postnatal period is regulated by
Kaliroi Engel +6 more
doaj +2 more sources
Lesion-induced changes of brevican expression in the perineuronal net of the superior vestibular nucleus [PDF]
Neural Regeneration Research, 2022 Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements, posture and vegetative functions. After a shorter or longer period of time, the vestibular function is partially or completely restored via a series of ...
Agnes Magyar +5 more
doaj +2 more sources