Results 41 to 50 of about 2,231 (191)
Neurobiology of Disease, 1999 GABA-interneurons immunoreactive (IR) for the calcium-binding protein parvalbumin are lost during the early stages of Creutzfeldt-Jakob disease (CJD) and diminution in their number may partially account for the neurological disturbances manifested in ...
Pavel V. Belichenko +4 more
doaj +1 more source
Perineuronal Nets Protect Fast-Spiking Interneurons Against Oxidative Stress
, 2023 A hallmark of schizophrenia pathophysiology is the dysfunction of cortical inhibitory GABA neurons expressing parvalbumin, which are essential for coordinating neuronal synchrony during various sensory and cognitive tasks. The high metabolic requirements
Do, Kim Q. +6 more
core +1 more source
Brain Research Bulletin, 2022 Hyaluronan (HA) is a core constituent of perineuronal nets (PNNs) that surround subpopulations of neurones. The PNNs control synaptic stabilization in both the developing and adult central nervous system, and disruption of PNNs has shown to reactivate ...
Jana Dubisova +8 more
doaj +1 more source
Semaphorins in Adult Nervous System Plasticity and Disease
Frontiers in Synaptic Neuroscience, 2021 Semaphorins, originally discovered as guidance cues for developing axons, are involved in many processes that shape the nervous system during development, from neuronal proliferation and migration to neuritogenesis and synapse formation.
Daniela Carulli +3 more
doaj +1 more source
Proteoglycans in Perineuronal Nets.
ACTA HISTOCHEMICA ET CYTOCHEMICA, 1999 Proteoglycans are one of the major constituents of the extracellular matrix and cell membranes. In the brain, there are two major proteoglycans, chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. In the adult mammalian central nervous system, some species of chondroitin sulfate proteoglycan are localized in the ‘perineuronal net ...
Matsui, Fumiko +2 more
openaire +2 more sources
Perineuronal Net Microscopy: From Brain Pathology to Artificial Intelligence. [PDF]
Int J Mol SciPerineuronal nets (PNN) are a special highly structured type of extracellular matrix encapsulating synapses on large populations of CNS neurons. PNN undergo structural changes in schizophrenia, epilepsy, Alzheimer’s disease, stroke, post-traumatic ...
Paveliev M +9 more
europepmc +2 more sources
Releasing Addiction Memories Trapped in Perineuronal Nets [PDF]
Trends in Genetics, 2018 Drug addiction can be conceptualized at a basic level as maladaptive learning and memory. Addictive substances elicit changes in brain circuitry involved in reward, cognition, and emotional state, leading to the formation and persistence of strong drug-associated memories that lead to craving and relapse.
Amy W. Lasek, Hu Chen, Wei-Yang Chen
openaire +2 more sources
Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity [PDF]
The Journal of Neuroscience, 2016 Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS. They appear to contribute to a wide range of diseases/disorders of the brain, are involved in recovery from spinal cord injury, and are altered during aging, learning and memory, and
Sorg, Barbara A +6 more
openaire +6 more sources
Fragmented burst neuron perineuronal net immunostaining.
, 2015 Parvalbumin-positive (PAV) putative burst neurons in the rostral interstitial nucleus of the medial longitudinal fasciculus (RIMLF) and in the paramedian pontine reticular formation (PPRF) were present in both the control and patient.
Wolfgang Härtig (232795) +6 more
core +1 more source
Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties
Cell Reports, 2019 Summary: Dendritic spines control synaptic transmission and plasticity by augmenting post-synaptic potentials and providing biochemical compartmentalization.
Angelica Foggetti +4 more
doaj +1 more source