Results 41 to 50 of about 1,903 (160)

Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity [PDF]

The Journal of Neuroscience, 2016
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS. They appear to contribute to a wide range of diseases/disorders of the brain, are involved in recovery from spinal cord injury, and are altered during aging, learning and memory, and
Sorg, Barbara A, Berretta, Sabina, Blacktop, Jordan M, Fawcett, James W, Kitagawa, Hiroshi, Kwok, Jessica CF, Miquel, Marta   +6 more
openaire   +6 more sources

The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning

Biology
Evidence is strong that, in addition to fine motor control, there is an important role for the cerebellum in cognition and emotion. The deep nuclei of the mammalian cerebellum also contain the highest density of perineural nets—mesh-like structures that ...
Bernard G. Schreurs, Deidre E. O’Dell, Desheng Wang   +2 more
doaj   +1 more source

Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties

Cell Reports, 2019
Summary: Dendritic spines control synaptic transmission and plasticity by augmenting post-synaptic potentials and providing biochemical compartmentalization.
Angelica Foggetti, Gilda Baccini, Philipp Arnold, Thomas Schiffelholz, Peer Wulff   +4 more
doaj   +1 more source

Perineuronal nets stabilize the grid cell network [PDF]

Nature Communications, 2019
Abstract Grid cells are part of a widespread network that supports navigation and spatial memory. Stable grid patterns appear late in development, in concert with extracellular matrix aggregates termed perineuronal nets (PNNs) that condense around inhibitory neurons.
Ane Charlotte Christensen, Kristian Kinden Lensjø, Mikkel Elle Lepperød, Svenn-Arne Dragly, Halvard Sutterud, Jan Sigurd Blackstad, Marianne Fyhn, Torkel Hafting   +7 more
openaire   +6 more sources

11-keto-β-boswellic acid and Z-guggulsterone suppress HMGB1/TLR4 pathway activity and modulate microglial polarization to remodel perineuronal nets after nerve injury

Journal of Advanced Research
Introduction: Remodeling of perineuronal nets is an emerging strategy for treating neuropathic pain (NP) and aligns with the traditional Chinese medicine concept of dispersing blood stasis dispersion and dredging collateral channels.
Yucheng Liao, Le Yang, Yi Ding, Chao Guo, Junping Hu, Xinliang Xu, Hui Zhu, Jianhua Yang, Minggao Zhao   +8 more
doaj   +1 more source

Comparative analysis of the methods for quantitative study of the perineuronal net microstructure

Учёные записки Казанского университета: Серия Естественные науки, 2022
Perineuronal nets (PNN) are a special and highly structured type of the CNS extracellular matrix. In past few years, the important role of PNN in the normal physiology of the CNS and the changes in their expression associated with some pathologies have ...
N.S. Lipachev, A.S. Dvoeglazova, A.A. Sadreeva, A.V. Aganov, M.N. Paveliev   +4 more
doaj   +1 more source

Loss of Perineuronal Net in ME7 Prion Disease [PDF]

Journal of Neuropathology & Experimental Neurology, 2008
Microglial activation and behavioral abnormalities occur before neuronal loss in experimental murine prion disease; the behavioral changes coincide with a reduction in synaptic plasticity. Because synaptic plasticity depends on an intact perineuronal net (PN), a specialized extracellular matrix that surrounds parvalbumin (PV)-positive GABAergic (gamma ...
Franklin, SL, Love, S, Greene, JRT, Betmouni, S   +3 more
openaire   +3 more sources

Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory

Cell Reports, 2019
Summary: Adolescence is a vulnerable period characterized by major cognitive changes. The mechanisms underlying the emergence of new cognitive functions are poorly understood.
Soledad Domínguez, Christophe Clément Rey, Ludivine Therreau, Aurélien Fanton, Dominique Massotte, Laure Verret, Rebecca Ann Piskorowski, Vivien Chevaleyre   +7 more
doaj   +1 more source

Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice

Biomolecules, 2020
The chondroitin sulfate (CS)-rich dense extracellular matrix surrounding neuron cell bodies and proximal dendrites in a mesh-like structure is called a perineuronal net (PNN).
Satomi Nadanaka, Shinji Miyata, Bai Yaqiang, Jun-ichi Tamura, Osami Habuchi, Hiroshi Kitagawa   +5 more
doaj   +1 more source

Hyperacute Interleukin‐1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion

Annals of Neurology, EarlyView.
Acute ischemic stroke due to large vessel occlusion is associated with rapid intravascular immune activation. Analysis of arterial blood sampled distal to the thrombus during mechanical thrombectomy revealed increased extracellular adenosine triphosphate (ATP) and interleukin‐1β (IL‐1β) levels, evidence of inflammasome priming in monocytes, and ...
Justine Münsterberg, Caspar Brekenfeld, Hanna Englert, Marius Piepke, Regine J. Dress, Martin Oertel, Tina Fischer, Romy Hackbusch, Mingming Zha, Haodi Cai, Christian Casar, Ines S. Schädlich, Leo Winter, Alina Jander, Karoline Degenhardt, Maxim Bester, Fabian Flottmann, Uta Hanning, Brigitte Holst, Anna Worthman, Johanna Hiefner, Berenike Rutz, Eckhard Schlemm, Götz Thomalla, Bettina H. Clausen, Ann M. Stowe, Immo Prinz, Thiruma V. Arumugam, Markus Glatzel, Thomas Renné, Jens Fiehler, Eva Tolosa, Tim Magnus, Mathias Gelderblom   +33 more
wiley   +1 more source