Results 61 to 70 of about 1,848 (164)

How Stress Influences the Dynamic Plasticity of the Brain’s Extracellular Matrix

Frontiers in Cellular Neuroscience, 2022
Diffuse and structured extracellular matrix (ECM) comprise ∼20% of the brain’s volume and play important roles in development and adult plasticity. Perineuronal nets (PNNs), specialized ECM structures that surround certain types of neurons in the brain ...
Blake J. Laham, Elizabeth Gould
doaj   +1 more source

From Lobectomy to Completion Thyroidectomy: A Cohort Study and Systematic Review

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction The suggested management of thyroid cancer has been revised in the 2015 American Thyroid Association Management Guidelines, suggesting thyroid lobectomy alone for low‐risk thyroid cancer. However, precise patient selection is essential to identify who may need completion thyroidectomy (CT), avoiding the burden of a second surgery.
Idit Tessler, Tzahi Yamin, Liroy Caracucli, Josh Krasner, Shaked Shivatzki, Nir A. Gecel, Eran E. Alon, Galit Avior   +7 more
wiley   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

Chondroitinase ABC Administration Facilitates Serotonergic Innervation of Motoneurons in Rats With Complete Spinal Cord Transection

Frontiers in Integrative Neuroscience, 2022
Chondroitinase ABC (ChABC) is an enzyme that degrades glycosaminoglycan side-chains of chondroitin sulfate (CS-GAG) from the chondroitin sulfate proteoglycan (CSPG) core protein. Previous studies demonstrated that the administration of ChABC after spinal
Masahito Takiguchi, Kanae Miyashita, Kohei Yamazaki, Kengo Funakoshi   +3 more
doaj   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Cilia in Nervous System Development, Function, and Disease

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley   +1 more source

Mechanotransduction in the Brain: Soliton Theory, Piezo Receptors and MR Elastography in Headache Pathophysiology

Brain and Behavior, Volume 16, Issue 5, May 2026.
ABSTRACT Purpose This narrative review aims to explore how incorporating mechanical and thermal dimensions can complement and extend the classical Hodgkin‐Huxley (HH) model to enrich the understanding of headache and pain pathophysiology. Method This review examines the integration of three distinct concepts with the HH model.
Joan Crespi, Axel Karl Gottfrid Nyman, Erling Tronvik, Lanfranco Pellesi, Igor Petrušić, Tobias Navarro Schröder   +5 more
wiley   +1 more source

Shaping Synapses by the Neural Extracellular Matrix

Frontiers in Neuroanatomy, 2018
Accumulating data support the importance of interactions between pre- and postsynaptic neuronal elements with astroglial processes and extracellular matrix (ECM) for formation and plasticity of chemical synapses, and thus validate the concept of a ...
Maura Ferrer-Ferrer, Alexander Dityatev, Alexander Dityatev, Alexander Dityatev   +3 more
doaj   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease

Aging Cell, Volume 25, Issue 4, April 2026.
A 14‐protein extracellular matrix aging clock derived from circulating matrisome proteins predicts chronological and biological age across cohorts and biofluids, distinguishes health from disease, and is modulated by rejuvenation interventions in mice, enabling the nomination of potential ECM targets for drug discovery to promote healthy aging ...
Loet Coenen, Adrian Molière, Benoit Lehallier, Jinte Middeldorp, Collin Y. Ewald   +4 more
wiley   +1 more source