Results 61 to 70 of about 2,231 (191)
Frontiers in NeuroanatomyNormal brain development requires continuous communication between developing neurons and their environment filled by a complex network referred to as extracellular matrix (ECM). The ECM is divided into distinct families of molecules including hyaluronic
Ildikó Wéber +5 more
doaj +1 more source
QUANTITATIVE HISTOCHEMICAL STUDY ON THE POSTNATAL DEVELOPMENT OF PERINEURONAL NETS IN THE RETROSPLENIAL CORTEX OF ALBINO RATS [PDF]
Assiut Veterinary Medical Journal, 2009 Reticular or lattice-like perineuronal coatings of condensed extracellular matrix (ECM), termed perineuronal nets (PNs), enriched in proteoglycans (PGs) and/or glycoproteins (GPs) were demonstrated to ensheath cell surfaces of certain neuronal circuits ...
R. SAYED
doaj +1 more source
WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy
Epilepsia, EarlyView.Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara +7 more
wiley +1 more source
Perineuronal nets and schizophrenia: The importance of neuronal coatings [PDF]
Neuroscience & Biobehavioral Reviews, 2014 Schizophrenia is a complex brain disorder associated with deficits in synaptic connectivity. The insidious onset of this illness during late adolescence and early adulthood has been reported to be dependent on several key processes of brain development including synaptic refinement, myelination and the physiological maturation of inhibitory neural ...
Byron K Y, Bitanihirwe, Tsung-Ung W, Woo
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2021 Cellular structures provide the physical foundation for the functionality of the nervous system, and their developmental trajectory can be influenced by the characteristics of the external environment that an organism interacts with.
Chia-Chien Chen +3 more
doaj +1 more source
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Perineuronal nets in brain physiology and disease
Seminars in Cell & Developmental Biology, 2019 Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular matrix structures with heterogeneous composition yet specific organization. They typically assemble around a subset of fast-spiking interneurons that are implicated in learning and memory.
Damien Testa +2 more
openaire +3 more sources
Dynamics of perineuronal nets over amphibian metamorphosis
Journal of Comparative Neurology, 2020 Abstract Extracellular matrix materials known as perineuronal nets (PNNs) have been shown to have remarkable consequences for the maturation of neural circuits and stabilization of behavior. It has been proposed that, due to the possibly long‐lived biochemical nature of their components, PNNs may be an important substrate by which ...
Jacob A. Edwards +2 more
openaire +3 more sources
The FEBS Journal, EarlyView.Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal +5 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2021 Mammalian brain circuits are wired by dynamic formation and remodeling during development to produce a balance of excitatory and inhibitory synapses. Synaptic regulation is mediated by a complex network of proteins including immunoglobulin (Ig)- class ...
Bryce W. Duncan +2 more
doaj +1 more source