Results 71 to 80 of about 2,231 (191)
Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó +4 more
wiley +1 more source
Absent or fragmented omnipause neuron perineuronal net immunostaining.
, 2015 Perineuronal nets around omnipause neurons (OPN) were absent or abnormal by all immunostaining methods, compared to a normal control subject. The left column demonstrates a control subject, whose parvalbumin (PAV)-positive OPN appear normal.
Wolfgang Härtig (232795) +6 more
core +1 more source
How Stress Influences the Dynamic Plasticity of the Brain’s Extracellular Matrix
Frontiers in Cellular Neuroscience, 2022 Diffuse and structured extracellular matrix (ECM) comprise ∼20% of the brain’s volume and play important roles in development and adult plasticity. Perineuronal nets (PNNs), specialized ECM structures that surround certain types of neurons in the brain ...
Blake J. Laham, Elizabeth Gould
doaj +1 more source
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, Volume 36, Issue 4, July 2026.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
From Lobectomy to Completion Thyroidectomy: A Cohort Study and Systematic Review
Clinical Endocrinology, Volume 105, Issue 1, Page 108-115, July 2026.ABSTRACT Introduction The suggested management of thyroid cancer has been revised in the 2015 American Thyroid Association Management Guidelines, suggesting thyroid lobectomy alone for low‐risk thyroid cancer. However, precise patient selection is essential to identify who may need completion thyroidectomy (CT), avoiding the burden of a second surgery.
Idit Tessler +7 more
wiley +1 more source
Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology
Advanced Science, Volume 13, Issue 33, 15 June 2026.Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu +4 more
wiley +1 more source
Cilia in Nervous System Development, Function, and Disease
MedComm – Future Medicine, Volume 5, Issue 2, June 2026.Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley +1 more source
Shaping Synapses by the Neural Extracellular Matrix
Frontiers in Neuroanatomy, 2018 Accumulating data support the importance of interactions between pre- and postsynaptic neuronal elements with astroglial processes and extracellular matrix (ECM) for formation and plasticity of chemical synapses, and thus validate the concept of a ...
Maura Ferrer-Ferrer +3 more
doaj +1 more source
Early adversity and the comorbidity between metabolic disease and psychopathology
The Journal of Physiology, Volume 604, Issue 11, Page 4338-4377, 1 June 2026.Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas +1 more
wiley +1 more source
Right medial temporal lobe mass in a 25‐year‐old male
Brain Pathology, EarlyView.
Jorge Samanamud +10 more
wiley +1 more source