Results 71 to 80 of about 1,848 (164)

Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan

Neural Plasticity, 2016
Perineuronal nets (PNNs) are lattice-like extracellular matrix structures composed of chondroitin sulfate proteoglycans (CSPGs). The appearance of PNNs parallels the decline of neural plasticity, and disruption of PNNs reactivates neural plasticity in ...
Shinji Miyata, Hiroshi Kitagawa
doaj   +1 more source

Reductionism in Engram Neuroscience

European Journal of Neuroscience, Volume 63, Issue 8, April 2026.
Reductionist methods inspire several seemingly incompatible explanations and ontologies. But such adversarial approaches can be fruitful for theorising in neuroscience. We argue that reductionist methods are at their most useful when coupled with integrative practices that include multiple heterarchical levels of organisation, various kinds of analysis,
Caitlin Mace, Fionn O'Sullivan, Scott R. Wilson   +2 more
wiley   +1 more source

Perineuronal nets in the rodent suprachiasmatic nucleus

Neuroscience
The circadian system maintains highly stable rhythms over the lifespan. The precision of the circadian clock emerges from the network organization of the master clock located in the suprachiasmatic nucleus (SCN). Perineuronal nets (PNNs), condensed extracellular matrix structures that are composed of chondroitin sulfate proteoglycans, help maintain ...
Patricia R. Blakely, Naila F. Jamani, Katelyn G. Horsley, Kiana Hampton, Michael C. Antle   +4 more
openaire   +2 more sources

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Right medial temporal lobe mass in a 25‐year‐old male

Brain Pathology, EarlyView.
Jorge Samanamud, Cheyanne C. Slocum, Michael Christian Virata, Zied Abdullaev, Kenneth Aldape, Melissa Umphlett, Raymund L. Yong, Thomas P. Naidich, Nadejda M. Tsankova, Jamie M. Walker, Timothy E. Richardson   +10 more
wiley   +1 more source

Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology

Journal of Neuroscience Research, Volume 104, Issue 3, March 2026.
Chondroitin sulfate proteoglycans (CSPGs) are critical components of the extracellular matrix in the central nervous system (CNS). In the developing CNS, CSPGs regulate neural precursor cells, neuronal migration, axon guidance, synapse organization, and peri‐neuronal net assembly.
Seyed Mojtaba Hosseini, Soheila Karimi‐Abdolrezaee   +1 more
wiley   +1 more source

Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Stress during adolescence or adulthood affects the ability of the prefrontal cortex (PFC) to adaptively regulate stress. Maladaptive adult stress leads to PFC hypofunction and a hypodopaminergic state in the medial, affect‐related ventral tegmental area (VTA), resulting in amotivation.
Daniela L. Uliana, Anthony A. Grace
wiley   +1 more source

Restoring vision in adult amblyopia by enhancing plasticity through deletion of the transcriptional repressor REST

iScience
Summary: Visual cortical plasticity is high during early life, but gradually decreases with development. This is due to the Otx2-driven maturation of intracortical inhibition that parallels the condensation of extracellular matrix components into ...
Dmytro Shmal, Giulia Mantero, Thomas Floss, Fabio Benfenati, José Fernando Maya-Vetencourt   +4 more
doaj   +1 more source

Adrenarche as a regulator of sensitivity to early adversity

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract The human brain is highly sensitive to early adversity, which can have long‐term consequences for later mental health. It is also a time of rapid learning of social, motor and other skills, including language. It is proposed that pre‐adrenarche, the only epoch in human development in which cortisol is not accompanied by dehydroepiandrosterone (
J. Herbert
wiley   +1 more source

Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential

Trends in Neurosciences, 2019
The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key
Reichelt, Amy C., Hare, Dominic J., Bussey, Timothy J., Saksida, Lisa M.   +3 more
openaire   +4 more sources