Results 1 to 10 of about 863 (94)

Reorganization of Spinal Cord Microarchitecture by Bioluminescent Optogenetic and Rehabilitative Interventions [PDF]

Cells
Spinal cord injury (SCI) induces persistent locomotor deficits that are closely associated with maladaptive structural plasticity of spinal neuronal circuits.
Tatyana Ageeva, Rezeda Shigapova, Aizilya Bilalova, Elizaveta Plotnikova, Amina Akmanova, Albert Rizvanov, Yana Mukhamedshina   +6 more
doaj   +2 more sources

High-intensity interval training remodels perineuronal nets in the medial prefrontal cortex to drive microglial polarization and alleviate osteoarthritis pain [PDF]

Scientific Reports
Knee osteoarthritis (OA) is a leading cause of chronic pain and disability, yet the mechanisms linking central neuroinflammation to pain persistence remain poorly defined.
Changsheng Lin, Xiao Zhang, Ziqi Ye, Fang Zhou, Kaizong Huang, Shiting Zhu, Anliang Chen, Xueping Li   +7 more
doaj   +2 more sources

Neurons ensheathed by perineuronal nets are prone to hyperphosphorylation of tau protein in the hibernating Syrian hamster brain [PDF]

Scientific Reports
Perineuronal nets (PNNs) are a specialized form of neuronal extracellular matrix that often ensheath highly active cells, such as parvalbumin-positive (PV+) interneurons.
Valerie Berrouschot, Mandy Sonntag, Katja Reimann, Carsten Jäger, Sven Martin, Max Holzer, Jens T. Stieler, Markus Morawski   +7 more
doaj   +2 more sources

Region-Specific Alterations of Perineuronal Net Expression in Postmortem Autism Brain Tissue

Frontiers in Molecular Neuroscience, 2022
Genetic variance in autism spectrum disorder (ASD) is often associated with mechanisms that broadly fall into the category of neuroplasticity. Parvalbumin positive neurons and their surrounding perineuronal nets (PNNs) are important factors in critical ...
Cheryl Brandenburg, Cheryl Brandenburg, Gene J. Blatt   +2 more
doaj   +3 more sources

Transcriptomic analysis of chronic social instability stress during adolescence reveals major shifts in the extracellular matrix [PDF]

Neurobiology of Stress
Adolescence represents a sensitive window of neural plasticity, when social experiences exert enduring influences on emotional and cognitive development.
Ming Yin Chu, Luca A. Hategan, Amanda M. Leonetti, Fiona O. Ramnaraign, Samuel Holm, Savithru Kannuri, Timothy A.B. McLean, Laura Neira-Diaz, Meghana C. Malagi, Cheryl M. McCormick, Brandon J. Walters   +10 more
doaj   +2 more sources

Nrg1 regulates cortical wiring and motor recovery upon traumatic injury [PDF]

Frontiers in Cellular Neuroscience
IntroductionTraumatic brain injury (TBI) is a leading cause of disability, yet molecular mechanisms supporting cortical repair remain poorly defined. While Neuregulin 1 (Nrg1) is essential for cortical development, its role in traumatic cortical injury ...
Ana González-Manteiga, Ana González-Manteiga, Carmen Navarro-González, Carmen Navarro-González, Ángela Rodríguez-Prieto, Maria Vittoria Zavaglia, Pietro Fazzari   +6 more
doaj   +2 more sources

Sustained diabetes remission induced by FGF1 involves a shift in transcriptionally distinct AgRP neuron subpopulations [PDF]

Molecular Metabolism
In rodent models of type 2 diabetes, a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) induces sustained remission of hyperglycemia. Overactive agouti-related peptide (AgRP) neurons, located in the hypothalamic arcuate
Nadia N. Aalling, Petar V. Todorov, Shad Hassan, Dylan M. Belmont-Rausch, Oliver Pugerup Christensen, Claes Ottzen Laurentiussen, Anja M. Jørgensen, Kimberly M. Alonge, Jarrad M. Scarlett, Zaman Mirzadeh, Jenny M. Brown, Michael W. Schwartz, Tune H. Pers   +12 more
doaj   +2 more sources

Sex differences in structural and receptor mRNA expression in the ventral anterior cingulate cortex and a potential role of perineuronal nets in monogamous pair bond establishment (Peromyscus californicus) [PDF]

Biology of Sex Differences
The monogamous California mouse (Peromyscus californicus) exhibits distinct behavioral changes during pair bond formation. Using a detailed temporal behavioral analysis over seven days, we found a rapid decrease in aggression within 24 h of pair ...
Candice L. Malone, Jiaxuan Li, Elsa M. Luebke, Leykza Carreras-Simons, Warren W. Treis, Emma R. Hammond, Patrick K. Monari, Catherine A. Marler   +7 more
doaj   +2 more sources

Altered inhibitory function in hippocampal CA2 contributes in social memory deficits in Alzheimer’s mouse model

iScience, 2022
Summary: Parvalbumin (PV)-expressing interneurons which are often associated with the specific extracellular matrix perineuronal net (PNN) play a critical role in the alteration of brain activity and memory performance in Alzheimer’s disease (AD).
Christophe Clément Rey, Vincent Robert, Guillaume Bouisset, Maïthé Loisy, Sébastien Lopez, Vanessa Cattaud, Camille Lejards, Rebecca Ann Piskorowski, Claire Rampon, Vivien Chevaleyre, Laure Verret   +10 more
doaj   +1 more source

Shock-Induced Damage Mechanism of Perineuronal Nets

Biomolecules, 2021
The perineuronal net (PNN) region of the brain’s extracellular matrix (ECM) surrounds the neural networks within the brain tissue. The PNN is a protective net-like structure regulating neuronal activity such as neurotransmission, charge balance, and ...
Khandakar Abu Hasan Al Mahmud, Fuad Hasan, Md Ishak Khan, Ashfaq Adnan   +3 more
doaj   +1 more source