Results 1 to 10 of about 885 (110)

Reorganization of Spinal Cord Microarchitecture by Bioluminescent Optogenetic and Rehabilitative Interventions [PDF]

Cells
Spinal cord injury (SCI) induces persistent locomotor deficits that are closely associated with maladaptive structural plasticity of spinal neuronal circuits.
Tatyana Ageeva, Rezeda Shigapova, Aizilya Bilalova, Elizaveta Plotnikova, Amina Akmanova, Albert Rizvanov, Yana Mukhamedshina   +6 more
doaj   +2 more sources

Cortical Layer-Specific Remodelling of Parvalbumin and Perineuronal Net Networks in Alcohol Use Disorder. [PDF]

Neuropathol Appl Neurobiol
Remodelling of perineuronal nets on cortical parvalbumin neurons in layers IV–VI occurs in human alcohol use disorder, suggests reduced plasticity in cortical output circuits driving habitual behaviour. ABSTRACT Background Alcohol use disorder (AUD) is a chronically relapsing condition marked by a pathological shift in behaviour, where excessive ...
Karas T, Prasad AA.
europepmc   +2 more sources

High-intensity interval training remodels perineuronal nets in the medial prefrontal cortex to drive microglial polarization and alleviate osteoarthritis pain [PDF]

Scientific Reports
Knee osteoarthritis (OA) is a leading cause of chronic pain and disability, yet the mechanisms linking central neuroinflammation to pain persistence remain poorly defined.
Changsheng Lin, Xiao Zhang, Ziqi Ye, Fang Zhou, Kaizong Huang, Shiting Zhu, Anliang Chen, Xueping Li   +7 more
doaj   +2 more sources

Neonatal Zika virus infection causes transient perineuronal net degradation

Frontiers in Cellular Neuroscience, 2023
Perineuronal nets (PNNs) form a specialized extracellular matrix that predominantly surrounds parvalbumin (PV)-expressing GABAergic inhibitory interneurons and help regulate neuronal activity. Their formation early in the postnatal period is regulated by
Ha-Na Lee, Derek D C Ireland, Bhanu P Tewari   +2 more
exaly   +3 more sources

Region-Specific Alterations of Perineuronal Net Expression in Postmortem Autism Brain Tissue

Frontiers in Molecular Neuroscience, 2022
Genetic variance in autism spectrum disorder (ASD) is often associated with mechanisms that broadly fall into the category of neuroplasticity. Parvalbumin positive neurons and their surrounding perineuronal nets (PNNs) are important factors in critical ...
Cheryl Brandenburg, Blatt Gene J, Gene J Blatt   +2 more
exaly   +3 more sources

Neurons ensheathed by perineuronal nets are prone to hyperphosphorylation of tau protein in the hibernating Syrian hamster brain [PDF]

Scientific Reports
Perineuronal nets (PNNs) are a specialized form of neuronal extracellular matrix that often ensheath highly active cells, such as parvalbumin-positive (PV+) interneurons.
Valerie Berrouschot, Mandy Sonntag, Katja Reimann, Carsten Jäger, Sven Martin, Max Holzer, Jens T. Stieler, Markus Morawski   +7 more
doaj   +2 more sources

Transcriptomic analysis of chronic social instability stress during adolescence reveals major shifts in the extracellular matrix [PDF]

Neurobiology of Stress
Adolescence represents a sensitive window of neural plasticity, when social experiences exert enduring influences on emotional and cognitive development.
Ming Yin Chu, Luca A. Hategan, Amanda M. Leonetti, Fiona O. Ramnaraign, Samuel Holm, Savithru Kannuri, Timothy A.B. McLean, Laura Neira-Diaz, Meghana C. Malagi, Cheryl M. McCormick, Brandon J. Walters   +10 more
doaj   +2 more sources

Nrg1 regulates cortical wiring and motor recovery upon traumatic injury [PDF]

Frontiers in Cellular Neuroscience
IntroductionTraumatic brain injury (TBI) is a leading cause of disability, yet molecular mechanisms supporting cortical repair remain poorly defined. While Neuregulin 1 (Nrg1) is essential for cortical development, its role in traumatic cortical injury ...
Ana González-Manteiga, Ana González-Manteiga, Carmen Navarro-González, Carmen Navarro-González, Ángela Rodríguez-Prieto, Maria Vittoria Zavaglia, Pietro Fazzari   +6 more
doaj   +2 more sources

Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology. [PDF]

J Neurosci Res
Chondroitin sulfate proteoglycans (CSPGs) are critical components of the extracellular matrix in the central nervous system (CNS). In the developing CNS, CSPGs regulate neural precursor cells, neuronal migration, axon guidance, synapse organization, and peri‐neuronal net assembly.
Hosseini SM, Karimi-Abdolrezaee S.
europepmc   +2 more sources

Sustained diabetes remission induced by FGF1 involves a shift in transcriptionally distinct AgRP neuron subpopulations [PDF]

Molecular Metabolism
In rodent models of type 2 diabetes, a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) induces sustained remission of hyperglycemia. Overactive agouti-related peptide (AgRP) neurons, located in the hypothalamic arcuate
Nadia N. Aalling, Petar V. Todorov, Shad Hassan, Dylan M. Belmont-Rausch, Oliver Pugerup Christensen, Claes Ottzen Laurentiussen, Anja M. Jørgensen, Kimberly M. Alonge, Jarrad M. Scarlett, Zaman Mirzadeh, Jenny M. Brown, Michael W. Schwartz, Tune H. Pers   +12 more
doaj   +2 more sources