Neural Plasticity, 2018 The perineuronal net (PNN) represents a lattice-like structure that is prominently expressed along the soma and proximal dendrites of parvalbumin- (PV-) positive interneurons in varied brain regions including the cortex and hippocampus.
P. Lorenzo Bozzelli +4 more
doaj +2 more sources
A Comprehensive Atlas of Perineuronal Net Distribution and Colocalization with Parvalbumin in the Adult Mouse Brain [PDF]
Cell Reports, 2023 Perineuronal nets (PNNs) surround specific neurons in the brain and are involved in various forms of plasticity and clinical conditions. However, our understanding of the PNN role in these phenomena is limited by the lack of highly quantitative maps of
Aurelia Viglione +13 more
core +6 more sources
Cortical Layer-Specific Remodelling of Parvalbumin and Perineuronal Net Networks in Alcohol Use Disorder. [PDF]
Neuropathol Appl NeurobiolRemodelling of perineuronal nets on cortical parvalbumin neurons in layers IV–VI occurs in human alcohol use disorder, suggests reduced plasticity in cortical output circuits driving habitual behaviour. ABSTRACT Background Alcohol use disorder (AUD) is a chronically relapsing condition marked by a pathological shift in behaviour, where excessive ...
Karas T, Prasad AA.
europepmc +2 more sources
Sex-Specific Effects of Experience With Pups on Perineuronal Net Expression in the Biparental California Mouse (Peromyscus californicus). [PDF]
J Comp NeurolThe neural mechanisms underlying behavioral sensitization to pups in adult virgin California mice are poorly understood. Here, we show that pup exposure alters perineuronal net (PNN) expression in the infralimbic medial prefrontal cortex of virgin male, but not female, California mice.
Acosta MC +3 more
europepmc +2 more sources
Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology. [PDF]
J Neurosci ResChondroitin sulfate proteoglycans (CSPGs) are critical components of the extracellular matrix in the central nervous system (CNS). In the developing CNS, CSPGs regulate neural precursor cells, neuronal migration, axon guidance, synapse organization, and peri‐neuronal net assembly.
Hosseini SM, Karimi-Abdolrezaee S.
europepmc +2 more sources
Frontiers in Cell and Developmental Biology, 2022 Fast-spiking parvalbumin interneurons are critical for the function of mature cortical inhibitory circuits. Most of these neurons are enwrapped by a specialized extracellular matrix (ECM) structure called perineuronal net (PNN), which can regulate their ...
Cornelius Mueller-Buehl +7 more
doaj +1 more source
Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory [PDF]
, 2017 Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory.
Fawcett, JW +3 more
core +4 more sources
TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults. [PDF]
, 2017 Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term disability, often leads to the development of epilepsy. Patients who develop post-injury epilepsy tend to have poor functional outcomes.
Becker, Albert +12 more
core +5 more sources
Frontiers in Cellular Neuroscience, 2022 Parvalbumin (PV)-positive cells are GABAergic fast-spiking interneurons that modulate the activity of pyramidal neurons in the medial prefrontal cortex (mPFC) and their output to brain areas associated with learning and memory.
Angela E. Gonzalez +8 more
doaj +1 more source
A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication [PDF]
, 2017 Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity.
Arranz +88 more
core +2 more sources