Results 11 to 20 of about 885 (110)

Sex differences in structural and receptor mRNA expression in the ventral anterior cingulate cortex and a potential role of perineuronal nets in monogamous pair bond establishment (Peromyscus californicus) [PDF]

Biology of Sex Differences
The monogamous California mouse (Peromyscus californicus) exhibits distinct behavioral changes during pair bond formation. Using a detailed temporal behavioral analysis over seven days, we found a rapid decrease in aggression within 24 h of pair ...
Candice L. Malone, Jiaxuan Li, Elsa M. Luebke, Leykza Carreras-Simons, Warren W. Treis, Emma R. Hammond, Patrick K. Monari, Catherine A. Marler   +7 more
doaj   +2 more sources

Altered inhibitory function in hippocampal CA2 contributes in social memory deficits in Alzheimer’s mouse model

iScience, 2022
Summary: Parvalbumin (PV)-expressing interneurons which are often associated with the specific extracellular matrix perineuronal net (PNN) play a critical role in the alteration of brain activity and memory performance in Alzheimer’s disease (AD).
Christophe Clément Rey, Vincent Robert, Guillaume Bouisset, Maïthé Loisy, Sébastien Lopez, Vanessa Cattaud, Camille Lejards, Rebecca Ann Piskorowski, Claire Rampon, Vivien Chevaleyre, Laure Verret   +10 more
doaj   +1 more source

Shock-Induced Damage Mechanism of Perineuronal Nets

Biomolecules, 2021
The perineuronal net (PNN) region of the brain’s extracellular matrix (ECM) surrounds the neural networks within the brain tissue. The PNN is a protective net-like structure regulating neuronal activity such as neurotransmission, charge balance, and ...
Khandakar Abu Hasan Al Mahmud, Fuad Hasan, Md Ishak Khan, Ashfaq Adnan   +3 more
doaj   +1 more source

Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System

Frontiers in Cellular Neuroscience, 2021
Cellular structures provide the physical foundation for the functionality of the nervous system, and their developmental trajectory can be influenced by the characteristics of the external environment that an organism interacts with.
Chia-Chien Chen, Chia-Chien Chen, Joshua C. Brumberg, Joshua C. Brumberg   +3 more
doaj   +1 more source

Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2

Frontiers in Cell and Developmental Biology, 2022
Fast-spiking parvalbumin interneurons are critical for the function of mature cortical inhibitory circuits. Most of these neurons are enwrapped by a specialized extracellular matrix (ECM) structure called perineuronal net (PNN), which can regulate their ...
Cornelius Mueller-Buehl, Jacqueline Reinhard, Lars Roll, Verian Bader, Verian Bader, Konstanze F. Winklhofer, Konstanze F. Winklhofer, Andreas Faissner   +7 more
doaj   +1 more source

Impact of Perineuronal Net Removal in the Rat Medial Prefrontal Cortex on Parvalbumin Interneurons After Reinstatement of Cocaine Conditioned Place Preference

Frontiers in Cellular Neuroscience, 2022
Parvalbumin (PV)-positive cells are GABAergic fast-spiking interneurons that modulate the activity of pyramidal neurons in the medial prefrontal cortex (mPFC) and their output to brain areas associated with learning and memory.
Angela E. Gonzalez, Angela E. Gonzalez, Emily T. Jorgensen, Jonathan D. Ramos, John H. Harkness, Jake A. Aadland, Travis E. Brown, Barbara A. Sorg, Barbara A. Sorg   +8 more
doaj   +1 more source

Chronic Toxoplasma gondii infection contributes to perineuronal nets impairment in the primary somatosensory cortex

Parasites & Vectors, 2022
Toxoplasma gondii is able to manipulate the host immune system to establish a persistent and efficient infection, contributing to the development of brain abnormalities with behavioral repercussions.
Ramayana Morais de Medeiros Brito, Ywlliane da Silva Rodrigues Meurer, Jully Anne Lemos Batista, Andréa Lima de Sá, Cássio Ricardo de Medeiros Souza, Janeusa Trindade de Souto, Valter Ferreira de Andrade-Neto   +6 more
doaj   +1 more source

Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice

Biomolecules, 2020
The chondroitin sulfate (CS)-rich dense extracellular matrix surrounding neuron cell bodies and proximal dendrites in a mesh-like structure is called a perineuronal net (PNN).
Satomi Nadanaka, Shinji Miyata, Bai Yaqiang, Jun-ichi Tamura, Osami Habuchi, Hiroshi Kitagawa   +5 more
doaj   +1 more source

60404 HIV Tat Induced Neuroinflammation

Journal of Clinical and Translational Science, 2021
IMPACT: Demonstrate the role of astrocyte released MMPs in response to pathogenic HIV protein Tat. OBJECTIVES/GOALS: In the presence of the pathogenic HIV protein Tat, astrocytes have been demonstrated to adopt an inflammatory phenotype as well as ...
Sean Carey, Kathleen Maguire-Zeiss
doaj   +1 more source

Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation

Neural Plasticity, 2019
The perineuronal net (PNN) is a mesh-like proteoglycan structure on the neuronal surface which is involved in regulating plasticity. The PNN regulates plasticity via multiple pathways, one of which is direct regulation of synapses through the control of ...
Heleen M. Van’t Spijker, Dáire Rowlands, Jean Rossier, Barbara Haenzi, James W. Fawcett, Jessica C. F. Kwok   +5 more
doaj   +1 more source