Results 11 to 20 of about 882 (110)

Cortical Layer-Specific Remodelling of Parvalbumin and Perineuronal Net Networks in Alcohol Use Disorder. [PDF]

Neuropathol Appl Neurobiol
Remodelling of perineuronal nets on cortical parvalbumin neurons in layers IV–VI occurs in human alcohol use disorder, suggests reduced plasticity in cortical output circuits driving habitual behaviour. ABSTRACT Background Alcohol use disorder (AUD) is a chronically relapsing condition marked by a pathological shift in behaviour, where excessive ...
Karas T, Prasad AA.
europepmc   +2 more sources

Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System

Frontiers in Cellular Neuroscience, 2021
Cellular structures provide the physical foundation for the functionality of the nervous system, and their developmental trajectory can be influenced by the characteristics of the external environment that an organism interacts with.
Chia-Chien Chen, Chia-Chien Chen, Joshua C. Brumberg, Joshua C. Brumberg   +3 more
doaj   +1 more source

Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2

Frontiers in Cell and Developmental Biology, 2022
Fast-spiking parvalbumin interneurons are critical for the function of mature cortical inhibitory circuits. Most of these neurons are enwrapped by a specialized extracellular matrix (ECM) structure called perineuronal net (PNN), which can regulate their ...
Cornelius Mueller-Buehl, Jacqueline Reinhard, Lars Roll, Verian Bader, Verian Bader, Konstanze F. Winklhofer, Konstanze F. Winklhofer, Andreas Faissner   +7 more
doaj   +1 more source

Sex-Specific Effects of Experience With Pups on Perineuronal Net Expression in the Biparental California Mouse (Peromyscus californicus). [PDF]

J Comp Neurol
The neural mechanisms underlying behavioral sensitization to pups in adult virgin California mice are poorly understood. Here, we show that pup exposure alters perineuronal net (PNN) expression in the infralimbic medial prefrontal cortex of virgin male, but not female, California mice.
Acosta MC, Warren ID, Saltzman W, Razak KA.   +3 more
europepmc   +2 more sources

Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology. [PDF]

J Neurosci Res
Chondroitin sulfate proteoglycans (CSPGs) are critical components of the extracellular matrix in the central nervous system (CNS). In the developing CNS, CSPGs regulate neural precursor cells, neuronal migration, axon guidance, synapse organization, and peri‐neuronal net assembly.
Hosseini SM, Karimi-Abdolrezaee S.
europepmc   +2 more sources

Impact of Perineuronal Net Removal in the Rat Medial Prefrontal Cortex on Parvalbumin Interneurons After Reinstatement of Cocaine Conditioned Place Preference

Frontiers in Cellular Neuroscience, 2022
Parvalbumin (PV)-positive cells are GABAergic fast-spiking interneurons that modulate the activity of pyramidal neurons in the medial prefrontal cortex (mPFC) and their output to brain areas associated with learning and memory.
Angela E. Gonzalez, Angela E. Gonzalez, Emily T. Jorgensen, Jonathan D. Ramos, John H. Harkness, Jake A. Aadland, Travis E. Brown, Barbara A. Sorg, Barbara A. Sorg   +8 more
doaj   +1 more source

Chronic Toxoplasma gondii infection contributes to perineuronal nets impairment in the primary somatosensory cortex

Parasites & Vectors, 2022
Toxoplasma gondii is able to manipulate the host immune system to establish a persistent and efficient infection, contributing to the development of brain abnormalities with behavioral repercussions.
Ramayana Morais de Medeiros Brito, Ywlliane da Silva Rodrigues Meurer, Jully Anne Lemos Batista, Andréa Lima de Sá, Cássio Ricardo de Medeiros Souza, Janeusa Trindade de Souto, Valter Ferreira de Andrade-Neto   +6 more
doaj   +1 more source

Neonatal Zika virus infection causes transient perineuronal net degradation

Frontiers in Cellular Neuroscience, 2023
Perineuronal nets (PNNs) form a specialized extracellular matrix that predominantly surrounds parvalbumin (PV)-expressing GABAergic inhibitory interneurons and help regulate neuronal activity. Their formation early in the postnatal period is regulated by
Kaliroi Engel, Ha-Na Lee, Bhanu P. Tewari, Aaron P. Lewkowicz, Derek D. C. Ireland, Mohanraj Manangeeswaran, Daniela Verthelyi   +6 more
doaj   +1 more source

Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice

Biomolecules, 2020
The chondroitin sulfate (CS)-rich dense extracellular matrix surrounding neuron cell bodies and proximal dendrites in a mesh-like structure is called a perineuronal net (PNN).
Satomi Nadanaka, Shinji Miyata, Bai Yaqiang, Jun-ichi Tamura, Osami Habuchi, Hiroshi Kitagawa   +5 more
doaj   +1 more source

60404 HIV Tat Induced Neuroinflammation

Journal of Clinical and Translational Science, 2021
IMPACT: Demonstrate the role of astrocyte released MMPs in response to pathogenic HIV protein Tat. OBJECTIVES/GOALS: In the presence of the pathogenic HIV protein Tat, astrocytes have been demonstrated to adopt an inflammatory phenotype as well as ...
Sean Carey, Kathleen Maguire-Zeiss
doaj   +1 more source