Perineuronal nets stabilize the grid cell network [PDF]
Nature Communications, 2021 Perineuronal nets may stabilize synaptic connections. Here, the authors show that removal of perineuronal nets disrupts both the temporal and spatial organization of grid cell firing.
Ane Charlotte Christensen +7 more
doaj +8 more sources
Do Perineuronal Nets Stabilize the Engram of a Synaptic Circuit? [PDF]
CellsPerineuronal nets (PNNs), a specialized form of extra cellular matrix (ECM), surround numerous neurons in the CNS and allow synaptic connectivity through holes in its structure.
Varda Lev-Ram +14 more
doaj +3 more sources
Primary cilia are required for the persistence of memory and stabilization of perineuronal nets
iScience, 2021 Summary: It is well established that the formation of episodic memories requires multiple hippocampal mechanisms operating on different time scales.
Vladimir Jovasevic +7 more
doaj +2 more sources
Shock-Induced Damage Mechanism of Perineuronal Nets [PDF]
Biomolecules, 2021 The perineuronal net (PNN) region of the brain’s extracellular matrix (ECM) surrounds the neural networks within the brain tissue. The PNN is a protective net-like structure regulating neuronal activity such as neurotransmission, charge balance, and ...
Khandakar Abu Hasan Al Mahmud +3 more
doaj +4 more sources
Perineuronal nets in the developing brain: implications for neurodevelopmental disorders [PDF]
Molecular BrainHere, we review recent findings on the development, functions, and alterations of perineuronal nets (PNNs) in relation to neurodevelopmental pathologies.
Jennifer M. Ackerman +3 more
doaj +2 more sources
Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long-term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets. [PDF]
J AnatChronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Szabó FP +4 more
europepmc +2 more sources
Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets [PDF]
Neurobiology of StressPerineuronal nets (PNNs) are a special form of central nervous system extracellular matrix enriched in hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins that regulate synaptic plasticity.
Jhoan S. Aguilar, Amy W. Lasek
doaj +2 more sources
Neural Regeneration Research, 2022 Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements, posture and vegetative functions. After a shorter or longer period of time, the vestibular function is partially or completely restored via a series of ...
Agnes Magyar +5 more
doaj +1 more source
Experience-dependent plasticity and modulation of growth regulatory molecules at central synapses. [PDF]
PLoS ONE, 2011 Structural remodeling or repair of neural circuits depends on the balance between intrinsic neuronal properties and regulatory cues present in the surrounding microenvironment.
Simona Foscarin +7 more
doaj +1 more source
iScience, 2023 Summary: In Alzheimer’s disease (AD), network hyperexcitability is frequently observed and associated with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought to be one of the key biological mechanisms of ...
Takehiro Kudo +10 more
doaj +1 more source