Results 1 to 10 of about 124,158 (160)

Perineuronal nets stabilize the grid cell network [PDF]

Nature Communications, 2021
Perineuronal nets may stabilize synaptic connections. Here, the authors show that removal of perineuronal nets disrupts both the temporal and spatial organization of grid cell firing.
Ane Charlotte Christensen, Kristian Kinden Lensjø, Mikkel Elle Lepperød, Svenn-Arne Dragly, Halvard Sutterud, Jan Sigurd Blackstad, Marianne Fyhn, Torkel Hafting   +7 more
doaj   +2 more sources

Ketamine preserves perineuronal nets in chronic stressed mice brain through the inhibition of microglia activation [PDF]

IBRO Neuroscience Reports
Background: Deeper understanding of ketamine’s mechanism of action would contribute to the discovery of novel therapeutic targets with fast-onset actions. To gain insight on the mechanism underlying the antidepressant-like effects of ketamine, we focused
Jingwen Yang, Ting Huang, Meng Wang, Yingrui Xu, Xuan Li, Changqi Li, Wenyu Cao, Liyan He, Huamao Zhou   +8 more
doaj   +2 more sources

Extracellular matrix and perineuronal nets in neural plasticity, memory, and epileptogenesis [PDF]

Frontiers in Molecular Neuroscience
In the mature brain, the extracellular matrix (ECM) molecules derived from neurons and glia accumulate in spatially distinct extracellular compartments, including a diffuse interstitial matrix and condensed perineuronal nets (PNNs), where they regulate ...
Hanxiao Zhu, Qiongfen Li, Yun Li, Wei Wang   +3 more
doaj   +2 more sources

11-keto-β-boswellic acid and Z-guggulsterone suppress HMGB1/TLR4 pathway activity and modulate microglial polarization to remodel perineuronal nets after nerve injury [PDF]

Journal of Advanced Research
Introduction: Remodeling of perineuronal nets is an emerging strategy for treating neuropathic pain (NP) and aligns with the traditional Chinese medicine concept of dispersing blood stasis dispersion and dredging collateral channels.
Yucheng Liao, Le Yang, Yi Ding, Chao Guo, Junping Hu, Xinliang Xu, Hui Zhu, Jianhua Yang, Minggao Zhao   +8 more
doaj   +2 more sources

Perineuronal nets in the developing brain: implications for neurodevelopmental disorders [PDF]

Molecular Brain
Here, we review recent findings on the development, functions, and alterations of perineuronal nets (PNNs) in relation to neurodevelopmental pathologies.
Jennifer M. Ackerman, Thomas James L. Ford, Shraddha Shridhar Kattewar, Woo-Yang Kim   +3 more
doaj   +2 more sources

Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets [PDF]

Neurobiology of Stress
Perineuronal nets (PNNs) are a special form of central nervous system extracellular matrix enriched in hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins that regulate synaptic plasticity.
Jhoan S. Aguilar, Amy W. Lasek
doaj   +2 more sources

Do Perineuronal Nets Stabilize the Engram of a Synaptic Circuit? [PDF]

Cells
Perineuronal nets (PNNs), a specialized form of extra cellular matrix (ECM), surround numerous neurons in the CNS and allow synaptic connectivity through holes in its structure.
Varda Lev-Ram, Sakina Palida Lemieux, Thomas J. Deerinck, Eric A. Bushong, Alex J. Perez, Denise R. Pritchard, Brandon H. Toyama, Sung Kyu R. Park, Daniel B. McClatchy, Jeffrey N. Savas, Michael Whitney, Stephen R. Adams, Mark H. Ellisman, John Yates, Roger Y. Tsien   +14 more
doaj   +2 more sources

Lesion-induced changes of brevican expression in the perineuronal net of the superior vestibular nucleus

Neural Regeneration Research, 2022
Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements, posture and vegetative functions. After a shorter or longer period of time, the vestibular function is partially or completely restored via a series of ...
Agnes Magyar, Eva Racz, Clara Matesz, Ervin Wolf, Peter Kiss, Botond Gaal   +5 more
doaj   +1 more source

Experience-dependent plasticity and modulation of growth regulatory molecules at central synapses. [PDF]

PLoS ONE, 2011
Structural remodeling or repair of neural circuits depends on the balance between intrinsic neuronal properties and regulatory cues present in the surrounding microenvironment.
Simona Foscarin, Danilo Ponchione, Ermira Pajaj, Ketty Leto, Maciej Gawlak, Grzegorz M Wilczynski, Ferdinando Rossi, Daniela Carulli   +7 more
doaj   +1 more source

Shock-Induced Damage Mechanism of Perineuronal Nets

Biomolecules, 2021
The perineuronal net (PNN) region of the brain’s extracellular matrix (ECM) surrounds the neural networks within the brain tissue. The PNN is a protective net-like structure regulating neuronal activity such as neurotransmission, charge balance, and ...
Khandakar Abu Hasan Al Mahmud, Fuad Hasan, Md Ishak Khan, Ashfaq Adnan   +3 more
doaj   +1 more source