Results 1 to 10 of about 134,149 (194)

Perineuronal nets in the developing brain: implications for neurodevelopmental disorders [PDF]

Molecular Brain
Here, we review recent findings on the development, functions, and alterations of perineuronal nets (PNNs) in relation to neurodevelopmental pathologies.
Jennifer M. Ackerman, Thomas James L. Ford, Shraddha Shridhar Kattewar, Woo-Yang Kim   +3 more
doaj   +3 more sources

The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies [PDF]

Cells
Perineuronal nets (PNNs) are specialized extracellular matrix structures that predominantly surround inhibitory neurons in the central nervous system (CNS). They have been identified as crucial regulators of synaptic plasticity and neuronal excitability.
Martin Schicht, Ingmar Blümcke, Friedrich Paulsen   +2 more
exaly   +3 more sources

Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets [PDF]

Neurobiology of Stress
Perineuronal nets (PNNs) are a special form of central nervous system extracellular matrix enriched in hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins that regulate synaptic plasticity.
Jhoan S. Aguilar, Amy W. Lasek
doaj   +3 more sources

Do Perineuronal Nets Stabilize the Engram of a Synaptic Circuit? [PDF]

Cells
Perineuronal nets (PNNs), a specialized form of extra cellular matrix (ECM), surround numerous neurons in the CNS and allow synaptic connectivity through holes in its structure.
Varda Lev-Ram, Sakina Palida Lemieux, Thomas J. Deerinck, Eric A. Bushong, Alex J. Perez, Denise R. Pritchard, Brandon H. Toyama, Sung Kyu R. Park, Daniel B. McClatchy, Jeffrey N. Savas, Michael Whitney, Stephen R. Adams, Mark H. Ellisman, John Yates, Roger Y. Tsien   +14 more
doaj   +3 more sources

Contribution of perineuronal nets to hyperexcitability in pilocarpine-induced status epilepticus [PDF]

Epilepsia
Changes in extracellular matrix (ECM) and highly condensed ECM structures called perineuronal nets (PNNs) have been reported in human patients with epilepsy as well as some animal models of epilepsy.
AnnaLin M. Woo, Erik J Fleischel, Dipan C Patel, Harald Sontheimer   +3 more
semanticscholar   +2 more sources

Estrogenic regulation of perineuronal nets in the mouse insular cortex and hippocampus [PDF]

Neuropharmacology
Estrogen has profound effects on the brain, affecting neuronal plasticity and behavior. Perineuronal nets (PNNs) are perforated extracellular matrix structures that mostly surround parvalbumin (PV)-expressing inhibitory interneurons and regulate neuronal
R. Nguyen, Razia Rahyab, A. Deshpande, E. Legge, Jonathas Almeida, Sarah Herz, Alexia L. Zylko, M. Damaj, Amy W. Lasek   +8 more
semanticscholar   +2 more sources

Disruption of Extracellular Matrix and Perineuronal Nets Modulates Extracellular Space Volume and Geometry [PDF]

J Neurosci
Extracellular matrix (ECM) is a network of macromolecules which has two forms—perineuronal nets (PNNs) and a diffuse ECM (dECM)—both influence brain development, synapse formation, neuroplasticity, CNS injury and progression of neurodegenerative diseases.
E. Syková, I. Vorisek, Z. Starčuk, Jirí Kratochvíla, I. Pavlova, Y. Ichikawa, Jessica C. F. Kwok, Eva Kmoníčková, Svitlana Myronchenko, T. Hromádka, T. Smolek, Martin Avila, Neha Basheer, N. Žilka   +13 more
semanticscholar   +2 more sources

Aggrecan immobilizes to perineuronal nets through hyaluronan-dependent and hyaluronan-independent binding activities [PDF]

J Biol Chem
Aggrecan (ACAN) is a large, secreted chondroitin sulfate proteoglycan that includes three globular regions named G1, G2, G3, and is decorated with multiple glycosaminoglycan attachments between its G2 and G3 domains.
Matthew Y. Otsuka, Leslie B. Essel, Ashis Sinha, Gabrielle Nickerson, Seth M. Mejia, Ashley Edge, Russell T. Matthews, Samuel Bouyain   +7 more
semanticscholar   +2 more sources

Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease [PDF]

J Neurosci
First discovered by Golgi, perineuronal nets (PNNs) are extracellular matrices that surround various neuron types in the nervous system. They have been found to emerge at the end of developmental critical periods and serve as “molecular brakes” on ...
Jon T. Sakata, K. Alonge, Emma J Diethorn, K. Krishnan, Noah E. P. Milman, Adam I. Ramsaran, Xinghaoyun Wan, B. Sorg   +7 more
semanticscholar   +2 more sources

Formation of perineuronal nets within a thalamocortical circuit shapes mechanical and thermal pain thresholds in mice with neuropathic pain [PDF]

Pain
Supplemental Digital Content is Available in the Text. Enzymatic degradation of perineuronal nets in the somatosensory cortex or reticular thalamic nucleus reduced pain behaviour suggesting causal association between perineuronal nets and nociceptive ...
G. Mascio, S. Notartomaso, R. P. Ginerete, Tiziana Imbriglio, D. Bucci, F. Liberatore, Alessia Ceccherelli, Sonia Castaldi, Gloria Zampini, Milena Cannella, Ferdinando Nicoletti, G. Battaglia, Valeria Bruno   +12 more
semanticscholar   +2 more sources