Results 21 to 30 of about 5,932 (219)
Perineuronal Net Dynamics in the Pathophysiology of Epilepsy [PDF]
Epilepsy Currents, 2021 Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap around GABAergic parvalbumin (PV) interneurons. During development, PNN formation terminates the critical period of neuroplasticity, a process that can be reversed by experimental ...
Lata Chaunsali +2 more
openaire +3 more sources
Neural Regeneration Research, 2022 Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements, posture and vegetative functions. After a shorter or longer period of time, the vestibular function is partially or completely restored via a series of ...
Agnes Magyar +5 more
doaj +1 more source
The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders [PDF]
Frontiers in Molecular Neuroscience, 2018 Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that PV cells and PNN are impaired in a variety of neurological disorders. PNN development and maintenance is necessary for a number of processes within the CNS, including regulation of ...
Teresa H. Wen +6 more
openaire +5 more sources
Circadian Rhythms of Perineuronal Net Composition [PDF]
eneuro, 2020 Abstract Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that envelop neurons and regulate synaptic functions. Long thought to be stable structures, PNNs have been recently shown to respond dynamically during learning, potentially regulating the formation of new synapses. We postulated that PNNs
Harry Pantazopoulos +10 more
openaire +3 more sources
Experience-dependent plasticity and modulation of growth regulatory molecules at central synapses. [PDF]
PLoS ONE, 2011 Structural remodeling or repair of neural circuits depends on the balance between intrinsic neuronal properties and regulatory cues present in the surrounding microenvironment.
Simona Foscarin +7 more
doaj +1 more source
Primary cilia are required for the persistence of memory and stabilization of perineuronal nets
iScience, 2021 Summary: It is well established that the formation of episodic memories requires multiple hippocampal mechanisms operating on different time scales.
Vladimir Jovasevic +7 more
doaj +1 more source
Perineuronal net degradation in epilepsy [PDF]
Epilepsia, 2015 SummaryObjectiveWe previously reported loss of perineuronal net (PN) immunohistochemical staining around parvalbumin‐positive interneurons in the hippocampus of rats after an episode of status epilepticus (SE). We hypothesized that the loss of thePNcould alter seizure susceptibility and that matrix metalloproteinases (MMPs) were candidates for ...
Elyse K. Rankin‐Gee +5 more
openaire +2 more sources
The extracellular matrix and perineuronal nets in memory
Molecular Psychiatry, 2022 AbstractAll components of the CNS are surrounded by a diffuse extracellular matrix (ECM) containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate proteoglycans (HSPGs), hyaluronan, various glycoproteins including tenascins and thrombospondin, and many other molecules that are secreted into the ECM and bind to ECM components. In addition,
Fawcett, James W +5 more
openaire +6 more sources
iScience, 2023 Summary: In Alzheimer’s disease (AD), network hyperexcitability is frequently observed and associated with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought to be one of the key biological mechanisms of ...
Takehiro Kudo +10 more
doaj +1 more source
Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory [PDF]
, 2017 Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory.
Fawcett, JW +3 more
core +4 more sources