Results 21 to 30 of about 3,965 (209)

Circadian Rhythms of Perineuronal Net Composition [PDF]

eneuro, 2020
Abstract Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that envelop neurons and regulate synaptic functions. Long thought to be stable structures, PNNs have been recently shown to respond dynamically during learning, potentially regulating the formation of new synapses. We postulated that PNNs
Harry Pantazopoulos, Barbara Gisabella, Lindsay Rexrode, David Benefield, Emrah Yildiz, Phoebe Seltzer, Jake Valeri, Gabriele Chelini, Anna Reich, Magdalena Ardelt, Sabina Berretta   +10 more
openaire   +3 more sources

The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders [PDF]

Frontiers in Molecular Neuroscience, 2018
Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that PV cells and PNN are impaired in a variety of neurological disorders. PNN development and maintenance is necessary for a number of processes within the CNS, including regulation of ...
Teresa H. Wen, Devin K. Binder, Devin K. Binder, Iryna M. Ethell, Iryna M. Ethell, Khaleel A. Razak, Khaleel A. Razak   +6 more
openaire   +5 more sources

Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input [PDF]

, 2022
The brain synaptic circuitry is formed as a result of pre-defined genetic programs and sensory experience during postnatal development. Perineuronal nets ensheath synaptic boutons and control several crucial features of the synapse physiology.
Osin, Yuri, Kochneva, Anastasia, Kiyasov, Andrei, Shaikhutdinov, Nurislam, Paveliev, Mikhail, Titova, Angelina, Arnst, Nikita, Melnikova, Anastasia, Dvoeglazova, Anastasia, Mavlikeev, Mikhail, Lipachev, Nikita, Aganov, Albert, Fedosimova, Svetlana   +12 more
core   +3 more sources

Perineuronal net degradation in epilepsy [PDF]

Epilepsia, 2015
SummaryObjectiveWe previously reported loss of perineuronal net (PN) immunohistochemical staining around parvalbumin‐positive interneurons in the hippocampus of rats after an episode of status epilepticus (SE). We hypothesized that the loss of thePNcould alter seizure susceptibility and that matrix metalloproteinases (MMPs) were candidates for ...
Elyse K. Rankin‐Gee, Paulette A. McRae, Esther Baranov, Stephanie Rogers, Luke Wandrey, Brenda E. Porter   +5 more
openaire   +2 more sources

The extracellular matrix and perineuronal nets in memory

Molecular Psychiatry, 2022
AbstractAll components of the CNS are surrounded by a diffuse extracellular matrix (ECM) containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate proteoglycans (HSPGs), hyaluronan, various glycoproteins including tenascins and thrombospondin, and many other molecules that are secreted into the ECM and bind to ECM components. In addition,
Fawcett, James W, Fyhn, Marianne, Jendelova, Pavla, Kwok, Jessica CF, Ruzicka, Jiri, Sorg, Barbara A   +5 more
openaire   +7 more sources

Perineuronal Nets Protect Fast-Spiking Interneurons Against Oxidative Stress

, 2023
A hallmark of schizophrenia pathophysiology is the dysfunction of cortical inhibitory GABA neurons expressing parvalbumin, which are essential for coordinating neuronal synchrony during various sensory and cognitive tasks. The high metabolic requirements
Do, Kim Q., Kraftsik, Rudolf, Morishita, Hirofumi, Cabungcal, Jan-Harry, Steullet, Pascal, Cuenod, Michel, Hensch, Takao   +6 more
core   +1 more source

Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development

Cells, 2021
The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
Emily S. Wilson, Karen Litwa
doaj   +1 more source

Perineuronal Nets and Metal Cation Concentrations in the Microenvironments of Fast-Spiking, Parvalbumin-Expressing GABAergic Interneurons: Relevance to Neurodevelopment and Neurodevelopmental Disorders

Biomolecules, 2021
Because of their abilities to catalyze generation of toxic free radical species, free concentrations of the redox reactive metals iron and copper are highly regulated.
Jessica A. Burket, Jason D. Webb, Stephen I. Deutsch   +2 more
doaj   +1 more source

Beta3Gn-T7 Is a Keratan Sulfate β1,3 N-Acetylglucosaminyltransferase in the Adult Brain

Frontiers in Neuroanatomy, 2022
Keratan sulfate (KS) glycan is covalently attached to a core protein of proteoglycans. KS is abundant in neuropils and presents densely in close proximity to the perineuronal region of the perineuronal net-positive neurons in the adult brain under ...
Yoshiko Takeda-Uchimura, Kazuchika Nishitsuji, Midori Ikezaki, Tomoya O. Akama, Yoshito Ihara, Fabrice Allain, Kenji Uchimura   +6 more
doaj   +1 more source

N-acetylgalactosamine positive perineuronal nets in the saccade-related-part of the cerebellar fastigial nucleus do not maintain saccade gain. [PDF]

PLoS ONE, 2014
Perineuronal nets (PNNs) accumulate around neurons near the end of developmental critical periods. PNNs are structures of the extracellular matrix which surround synaptic contacts and contain chondroitin sulfate proteoglycans.
Adrienne Mueller, Adam Davis, Steven S Carlson, Farrel R Robinson   +3 more
doaj   +1 more source