Results 21 to 30 of about 134,149 (194)

Degradation of perineuronal nets in hippocampal CA2 explains the loss of social cognition memory in Alzheimer's disease [PDF]

Alzheimers Dement
Loss of social cognition memory impairs Alzheimer's disease (AD) patients to recognize family members, friends, and caregivers. We investigate the role of perineuronal nets (PNNs), specialized coats of extracellular matrix around hippocampal CA2 neurons ...
Lata Chaunsali, Jiangtao Li, Erik J Fleischel, Courtney E. Prim, Izabela Kasprzak, Sha Jiang, Silky Hou, Miguel Escalante, Elise C Cope, M. L. Olsen, B. Tewari, Harald Sontheimer   +11 more
semanticscholar   +2 more sources

Enriched environment requires the remodeling of hippocampal perineuronal nets to trigger memory improvement in Alzheimer’s mouse model [PDF]

iScience
Summary Alzheimer’s disease (AD) is a major neurodegenerative disorder influenced by both genetic and environmental factors. Mentally stimulating activities are believed to reduce cognitive decline by establishing a cognitive reserve, although the ...
G. Bouisset, Fanny J. Tixier, Tatiana Dupak, Camille Lejards, L. Verret   +4 more
semanticscholar   +2 more sources

Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice [PDF]

Nat Neurosci
Perineuronal nets (PNNs) are densely packed extracellular matrices that cover the cell body of fast-spiking inhibitory neurons. PNNs stabilize synapses inhibiting synaptic plasticity.
B. Tewari, AnnaLin M. Woo, Courtney E. Prim, Lata Chaunsali, Dipan C Patel, Ian F. Kimbrough, Kaliroi Engel, J. Browning, Susan L. Campbell, Harald Sontheimer   +9 more
semanticscholar   +2 more sources

Resilience to Alzheimer's disease associates with alterations in perineuronal nets [PDF]

Alzheimers Dement
Some individuals show intact cognition despite the presence of neuropathological hallmarks of Alzheimer's disease (AD). The plasticity of parvalbumin (PV)‐containing interneurons might contribute to resilience.
L. de Vries, Anouck Bahnerth, Dick F. Swaab, J. Verhaagen, Daniela Carulli   +4 more
semanticscholar   +2 more sources

Post-Stroke Recovery in Relation to Parvalbumin-Positive Interneurons and Perineuronal Nets [PDF]

Neurorehabil Neural Repair
Background: There is a critical time window of post-stroke neuroplasticity when spontaneous behavioral recovery occurs. Potential factors responsible for this heightened plasticity are the reduction of parvalbumin-immunoreactive (PV+) interneuron ...
Lydia M. Kuhl, M. Jeffers, Nicolay Hristozov, S. Karthikeyan, M. McDonald, Aisha Hufnagel, Anthony Carter, N. Dancause, Dale Corbett   +8 more
semanticscholar   +2 more sources

Impact of Perineuronal Nets on Electrophysiology of Parvalbumin Interneurons, Principal Neurons, and Brain Oscillations: A Review

Frontiers in Synaptic Neuroscience, 2021
Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround specific neurons in the brain and spinal cord, appear during critical periods of development, and restrict plasticity during adulthood.
Barbara Sorg, Sorg Barbara A
exaly   +3 more sources

Age‐dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy [PDF]

Epilepsia Open
Perineuronal nets (PNN) are specialized extracellular matrix (ECM) components of the central nervous system, frequently accumulating at the surface of inhibitory GABAergic interneurons.
Annika Lehner, L. Hoffmann, S. Rampp, R. Coras, Friedrich Paulsen, Renato Frischknecht, H. Hamer, Katrin Walther, Sebastian Brandner, Wiebke Hofer, Tom Pieper, L. Reisch, C. Bien, I. Blumcke   +13 more
semanticscholar   +2 more sources

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets [PDF]

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +2 more sources

Hypothalamic Perineuronal Nets Are Regulated by Sex and Dietary Interventions [PDF]

Frontiers in Physiology, 2021
Perineuronal nets (PNNs) are widely present in the hypothalamus, and are thought to provide physical protection and ion buffering for neurons and regulate their synaptic plasticity and intracellular signaling.
Nan Zhang, Nan Zhang, Nan Zhang, Zili Yan, Hailan Liu, Meng Yu, Yang He, Hesong Liu, Chen Liang, Longlong Tu, Lina Wang, Na Yin, Junying Han, Nikolas Scarcelli, Yongjie Yang, Chunmei Wang, Tianshu Zeng, Tianshu Zeng, Lu-Lu Chen, Lu-Lu Chen, Yong Xu, Yong Xu   +21 more
doaj   +4 more sources

Stress Sensitization of Neurons in the Dentate Gyrus Is Dependent on Neuronal Interleukin-1 Receptor Signaling and Is Associated with Increased Synaptic Plasticity, Perineuronal Nets, and Excitatory/Inhibitory Input Imbalance [PDF]

J Neurosci
Repeated social defeat (RSD) in mice causes sensitization of hippocampal neurons associated with enhanced contextual fear memory. Because enhanced fear memory is an integral component of posttraumatic stress disorder, the physiological basis of neuronal ...
Ethan J. Goodman, Riley M Britt, Fangli Zhao, Amara C. Davis, L. Wangler, Ethan Emami, Samuel P Swanson, C. Askwith, J. Sheridan, Jonathan P. Godbout   +9 more
semanticscholar   +2 more sources